Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Linda P, Dwoskin"'
Autor:
Emily Slade, Linda P. Dwoskin, Guo-Qiang Zhang, Jeffery C. Talbert, Jin Chen, Patricia R. Freeman, Kathleen M. Kantak, Emily R. Hankosky, Sajjad Fouladvand, Amy L. Meadows, Heather M. Bush
Publikováno v:
Journal of Clinical and Translational Science, Vol 5 (2021)
The availability of large healthcare datasets offers the opportunity for researchers to navigate the traditional clinical and translational science research stages in a nonlinear manner. In particular, data scientists can harness the power of large h
Externí odkaz:
https://doaj.org/article/05757d77a7b44f62bcb12dc72cb9f094
Autor:
Sajjad Fouladvand, Jeffery Talbert, Linda P. Dwoskin, Heather Bush, Amy L. Meadows, Lars E. Peterson, Yash R. Mishra, Steven K. Roggenkamp, Fei Wang, Ramakanth Kavuluru, Jin Chen
Publikováno v:
IEEE Journal of Biomedical and Health Informatics. :1-10
ObjectiveTo compare the effectiveness of multiple artificial intelligence (AI) models with unweighted Opioid Risk Tool (ORT) in opioid use disorder (OUD) prediction.Materials and MethodsThis is a retrospective cohort study of deidentified claims data
Autor:
Takuya Okada, Naizhen Wu, Katsuki Takashima, Jungoh Ishimura, Hiroyuki Morita, Takuya Ito, Takeshi Kodama, Yuhei Yamasaki, Shin-ichi Akanuma, Yoshiyuki Kubo, Ken-ichi Hosoya, Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu Sasaoka, Takahiro Shimizu, Hideki Sakai, Linda P. Dwoskin, Syed R. Hussaini, Ralph A. Saporito, Naoki Toyooka
Publikováno v:
Molecules, Vol 26, Iss 24, p 7529 (2021)
The total synthesis of two decahydroquinoline poison frog alkaloids ent-cis-195A and cis-211A were achieved in 16 steps (38% overall yield) and 19 steps (31% overall yield), respectively, starting from known compound 1. Both alkaloids were synthesize
Externí odkaz:
https://doaj.org/article/9cd23016351e46a1b6945dae2ed2a376
Autor:
Nicole L. Rumian, Carolyn Nicole Brown, Tara B. Hendry-Hofer, Thomas Rossetti, James E. Orfila, Jonathan E. Tullis, Linda P. Dwoskin, Olivia R. Buonarati, John E. Lisman, Nidia Quillinan, Paco S. Herson, Vikhyat S. Bebarta, K. Ulrich Bayer
Publikováno v:
Journal of Biological Chemistry. 299:104693
Autor:
Guo-Qiang Zhang, Linda P. Dwoskin, Patricia R. Freeman, Sajjad Fouladvand, Jin Chen, Amy Lynn Meadows, Jeffery C. Talbert, Emily Slade, Heather M. Bush, Emily R. Hankosky, Kathleen M. Kantak
Publikováno v:
Journal of Clinical and Translational Science
The availability of large healthcare datasets offers the opportunity for researchers to navigate the traditional clinical and translational science research stages in a nonlinear manner. In particular, data scientists can harness the power of large h
Autor:
Jing Chen, Elizabeth S. Hausman, Wen Zhang, Zachary M. Martin, Chang-Guo Zhan, K. M. Kondratyuk, Agripina G. Deaciuc, Chunming Liu, Mykhaylo S. Frasinyuk, Haining Zhu, Liliia M. Kril, Vitaliy M. Sviripa, Jessica S. Blackburn, David S. Watt, Przemyslaw Wyrebek, Yanqi Xie, Xifu Liu, Svitlana P. Bondarenko, Tianxin Yu, Linda P. Dwoskin
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic variants of the (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one scaffold that possessed low nanomolar in vitro potency in cell proliferation assays using vario
Autor:
Emily K Dennis, Huy X. Ngo, Linda P. Dwoskin, Sylvie Garneau-Tsodikova, Stefan Kwiatkowski, Nishad Thamban Chandrika, Keith D. Green, Sanjib K. Shrestha, Agripina G. Deaciuc, David S. Watt
Publikováno v:
European Journal of Medicinal Chemistry. 164:273-281
N,N′-Diaryl-bishydrazones of [1,1′-biphenyl]-3,4′-dicarboxaldehyde, [1,1′-biphenyl]-4,4′-dicarboxaldehyde, and 4,4′-bisacetyl-1,1-biphenyl exhibited excellent antifungal activity against a broad spectrum of filamentous and non-filamentous
Autor:
Linda P. Dwoskin, Satheesh Gujarathi, Na-Ra Lee, Kiranbabu Siripurapu, Shobanbabu Bommagani, Guangrong Zheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:471-476
Novel quinuclidinyl N-phenylcarbamate analogs were synthesized, and binding affinities at M1-M5 muscarinic acetylcholine receptor (mAChR) subtypes were determined using Chinese hamster ovary (CHO) cell membranes stably expressing one specific subtype
Autor:
Michael T. Bardo, Peter A. Crooks, Kimberly Nixon, Linda P. Dwoskin, Richard L. Bell, Sarah E. Maggio, Guangrong Zheng, Meredith A. Saunders, Mark A. Prendergast
Publikováno v:
Drug and Alcohol Dependence. 193:154-161
Background Although pharmacotherapies are available for alcohol (EtOH) or tobacco use disorders individually, it may be possible to develop a single pharmacotherapy to treat heavy drinking tobacco smokers by capitalizing on the commonalities in their
Publikováno v:
Behavioural Pharmacology. 29:87-97
Methamphetamine is a potent psychostimulant with high abuse rates. Currently, there is no Food and Drug Administration-approved pharmacotherapy for methamphetamine addiction. Ideally, a pharmacotherapy should selectively decrease methamphetamine self