Výsledky vyhledávání - "Linda Ohrmund"

Monitoring of adalimumab and antibodies-to-adalimumab levels in patient serum by the homogeneous mobility shift assay

Autor: Rukmini Reddy, Reshma Shringarpure, Shawn Shah, Emil Chuang, Sharat Singh, Kevin McCowen, Jared Salbato, Steven Lockton, Scott Hauenstein, Linda Ohrmund, S. T. Wang

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. :39-44

This report describes the analytical validation and application of the homogeneous mobility shift assay (HMSA) method for the measurement of adalimumab and human antibodies-to-adalimumab (ATA) in serum samples from patients who have lost response to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a609babaf2e3630d9d414390a666a9df

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Development and validation of a homogeneous mobility shift assay for the measurement of infliximab and antibodies-to-infliximab levels in patient serum

Autor: Rukmini Reddy, Steven Lockton, Patrick Monk, S. T. Wang, Jared Salbato, Scott Hauenstein, Nicholas Chi-Kwan Ling, Sharat Singh, Linda Ohrmund

Publikováno v: Journal of Immunological Methods. 382:177-188

Antibody-based drugs such as infliximab (IFX) are effective for the treatment of inflammatory bowel disease (IBD) and other immune-mediated disorders. The development of antibodies against these drugs may result in unfavorable consequences, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132cbabe859d8e154d183f667d62c6d5
https://doi.org/10.1016/j.jim.2012.06.002

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AC-260584, an orally bioavailable M1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model

Autor: Tracy A. Spalding, Robert E. Davis, Abhishek Bajpai, Thomas R. Ott, Mikael Friberg, Jelveh Lameh, Krista McFarland, Stefania Risso Bradley, Derek Nguyen, Ali Tabatabaei, Linda Ohrmund, Hans H. Schiffer, Douglas W. Bonhaus, Ethan S. Burstein, Thomas Son

Publikováno v: Neuropharmacology. 58:365-373

The recent discovery of allosteric potentiators and agonists of the muscarinic M(1) receptor represents a significant advance in the muscarinic receptor pharmacology. In the current study we describe the receptor pharmacology and pro-cognitive action

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea3cde7b5fcbb28425788ac8a6837a5
https://doi.org/10.1016/j.neuropharm.2009.10.003

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Antibody response to infliximab and its impact on pharmacokinetics can be transient

Autor: Severine Vermeire, Niels Vande Casteele, Ann Gils, Linda Ohrmund, Scott Hauenstein, Sharat Singh, Paul Rutgeerts

Publikováno v: The American journal of gastroenterology. 108(6)

Infliximab (IFX) is successfully used in the treatment of inflammatory bowel diseases but some patients generate antibodies to IFX (ATI) jeopardizing the pharmacokinetics of the drug. Little is known about the factors influencing ATI formation and wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e54f0c9515dc239fabbc667a99133c
https://pubmed.ncbi.nlm.nih.gov/23419382

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Akademický článek

Efficacy and Immunogenicity of a Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine in Cynomolgus Macaques.

Autor: Camargos, Vidyleison N.¹ (AUTHOR) vinevesc@utmb.edu, Rossi, Shannan L.² (AUTHOR) slrossi@utmb.edu, Juelich, Terry L.¹ (AUTHOR) tljuelic@utmb.edu, Smith, Jennifer K.¹ (AUTHOR) jeksmith@utmb.edu, Vasilakis, Nikos³ (AUTHOR) nivasila@utmb.edu, Freiberg, Alexander N.² (AUTHOR), Nichols, Rick⁴ (AUTHOR) rnichols@phvaccines.com, Fusco, Joan⁴ (AUTHOR) slrossi@utmb.edu

Publikováno v: Viruses (1999-4915). Aug2024, Vol. 16 Issue 8, p1181. 22p.

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