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The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy

Autor: Richard L Whelan, Vesna Cekic, Elie Sutton, Xiaohong Yan, H M C Shantha Kumara, Daniel Kirchoff, Sonali A C Herath, Linda Njoh, Aqeel Ahmed, Otavia L. Caballero, Tao Su

Publikováno v: Oncotarget

Introduction Calcium-binding tyrosine phosphorylation-regulated protein (CABYR) is expressed in the human germ line but not in adult human tissues, thus, it is considered a cancer testis protein. The aim of this study is to evaluate the CABYR isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f183a958fd84e9d29313d669b182ae
http://europepmc.org/articles/PMC7939523

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P-Cadherin (CDH3) is overexpressed in colorectal tumors and has potential as a serum marker for colorectal cancer monitoring

Autor: Kumara Hmcs, Geoffrey Bellini, Caballero Ol, Richard L. Whelan, Aqeel Ahmed, Herath Sac, Tao Su, Cekic, Linda Njoh

Publikováno v: Oncoscience

Introduction Placental-Cadherin (CDH3) is a cell adhesion molecule vital to cellular localization and tissue integrity. It is highly expressed in the placenta (PLC)and is overexpressed by many types of cancer. P-cadherin levels in colorectal cancer (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b69dcb8eaad6d0e86eb03a70f4719ec
http://europepmc.org/articles/PMC5672898

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Warm and Humidified Versus Cold and Dry CO2 Pneumoperitoneum in Minimally Invasive Colon Resection: A Randomized Controlled Trial

Autor: Vesna Cekic, Linda Njoh, H. M. C. Shantha Kumara, Michael J Grieco, Richard L. Whelan, Geoffrey Bellini, Xiaohong Yan, Elie Sutton

Publikováno v: Surgical Innovation. 24:471-482

Introduction. Peritoneal insufflation with warm-humidified (WH) CO2 gas during minimally invasive surgical procedures is purported to prevent hypothermia and peritoneal desiccation and is associated with decreased postoperative IL-6 levels. This rand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66cc3e11f6f407726754456b08c5fb7d
https://doi.org/10.1177/1553350617715834

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Surgical Treatment of Diverticulitis

Autor: Hiromichi Miyagaki, Richard L. Whelan, Linda Njoh, H. M. C. Shantha Kumara, Vesna Cekic, Rebecca Rhee, Xiaohong Yan

Publikováno v: Surgical Innovation. 23:277-283

Introduction. Laparoscopic (LAP) colectomy is now the “gold” standard for diverticulitis; the role of hand-assisted LAP (HAL) and Open methods today is unclear. This study assessed the elective use of these methods for diverticulitis. Methods. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886f4805fcf59102c4247a0042b1d288
https://doi.org/10.1177/1553350615618285

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Expression of the cancer testis antigen IGF2BP3 in colorectal cancers; IGF2BP3 holds promise as a specific immunotherapy target

Autor: Andrew J. G. Simpson, Richard L. Whelan, Otavia L. Caballero, Aqeel Ahmed, Daniel Kirchoff, Tao Su, Linda Njoh, Hmc Shantha Kumara, Carlos Cordon-Cardo, Sonali A. C. Herath, Vesna Cekic

Publikováno v: Oncoscience

Introduction IGF2BP3 (IMP3) is a mRNA binding protein that regulates IGF2 translation and function during embryogenesis. Because IGF2BP3 is undetectable in adult human tissues except the testis, and increased IGF2BP3 expression has been noted in seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7856873e41f5b90cbe43619e9432ae
http://europepmc.org/articles/PMC4506364

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Warm and Humidified Versus Cold and Dry CO

Autor: Elie, Sutton, Geoffrey, Bellini, Michael J, Grieco, H M C Shantha, Kumara, Xiaohong, Yan, Vesna, Cekic, Linda, Njoh, Richard L, Whelan

Publikováno v: Surgical innovation. 24(5)

Peritoneal insufflation with warm-humidified (WH) COOperative and short-term clinical data plus perioperative blood samples were collected on MICR patients randomized to receive either WH (36.7°C, 95% humidity) or CD (room temperature, 0% humidity)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d50e533321124e2a49634745173838f9
https://pubmed.ncbi.nlm.nih.gov/28653583

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Minimally Invasive Colorectal Resection for Benign Pathology Is Associated With Persistent Proangiogenic Plasma Compositional Changes

Autor: Daniel Kirchoff, Richard L. Whelan, H. M. C. Shantha Kumara, Sonali A. C. Herath, Linda Njoh, Elizabeth A. Myers, Nadav Dujovny, Xiaohong Yan

Publikováno v: Diseases of the Colon & Rectum. 57:740-746

BACKGROUND Minimally invasive colorectal resection for cancer is associated with increased plasma levels of numerous proangiogenic proteins for 3 to 4 weeks postoperatively, and plasma from postoperative weeks 2 and 3 stimulates proangiogenic endothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1d2f73a457d651533d79f3ddb0227a
https://doi.org/10.1097/dcr.0000000000000062

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The rate for the use of hand-assisted laparoscopic methods is directly proportional to body mass index

Autor: Joon Ho Jang, Linda Njoh, Daniel L. Feingold, Samer A Naffouje, Tracey D. Arnell, Richard L. Whelan, Elizabeth A. Myers, Vesna Cekic

Publikováno v: Surgical Endoscopy. 28:108-115

Hand-assisted laparoscopic (HAL) colorectal resection remains controversial. Critics believe HAL methods lead to decreased use of laparoscopically assisted (LA) methods. Proponents believe selective HAL use increases minimally invasive surgery (MIS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a82cbc8c2bd22e28d33271e2d90569
https://doi.org/10.1007/s00464-013-3135-9

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Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models

Autor: Michael Grieco, H. M. C. Shantha Kumara, Daniel Kirchoff, Richard L. Whelan, Samer A Naffouje, Sonali A. C. Herath, Joon Ho Jang, Thomas R. Gardner, Xiaohong Yan, Linda Njoh

Publikováno v: Surgical Endoscopy. 26:1856-1864

Perioperative anticancer therapy that does not impair wound healing is needed to counter the persistent proangiogenic plasma compositional changes that occur after colorectal resection. Polyphenon E (PolyE), a green tea derivative (main component EGC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b2427756b5897723a5117afcaa49d8
https://doi.org/10.1007/s00464-011-2114-2

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Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion

Autor: Samer A Naffouje, Michael H. Grieco, Neil Hyman, Richard L. Whelan, Sonali A. C. Herath, Linda Njoh, Nadav Dujovny, Matthew F. Kalady, H. M. C. Shantha Kumara, Daniel Kirchoff

Publikováno v: Surgical Endoscopy. 26:790-795

Angiogenesis is central to wound healing and tumor growth. Postoperative (postop) plasma from weeks 2 and 3 after minimally invasive colorectal resection (MICR) stimulates endothelial cell (EC) migration (MIG), invasion (INV), and proliferation (all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb6084e715f3b20fe64c46135f80242
https://doi.org/10.1007/s00464-011-1953-1

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