Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Linda Miallau"'
Autor:
Scarlett Kiyeleko, Sofiane Hocine, Giséle Mautino, Mélaine Kuenemann, Agata Nawrotek, Linda Miallau, Laurent-Michel Vuillard, Olivier Mirguet, Andras Kotschy, Stephen Hanessian
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
We describe the synthesis of a series of 3-t-butyl 5-aminopyrazole p-substituted arylamides as inhibitors of serine-threonine25 (STK25), an enzyme implicated in the progression of non-alcoholic fatty liver disease (NAFLD). Appending a p-N-pyrrolidino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed826164ebfa1e4b6e3a53c105d52926
https://pubmed.ncbi.nlm.nih.gov/36030002
https://pubmed.ncbi.nlm.nih.gov/36030002
Autor:
William R. Jacobs, Tung Phan, Janet Chiang, Paras Jain, Irina Chernishof, David Eisenberg, Michelle E. Maxson, Linda Miallau, Sum Chan, Christine J. Ahn, Mark A. Arbing, Duilio Cascio
Publikováno v:
Structure. 21:627-637
SummaryThe Mycobacterium tuberculosis (Mtb) genome encodes approximately 90 toxin-antitoxin protein complexes, including three RelBE family members, which are believed to play a major role in bacterial fitness and pathogenicity. We have determined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f968f2bb2fa3938e373cda4aa6e9f01
https://doi.org/10.1016/j.str.2013.02.008
https://doi.org/10.1016/j.str.2013.02.008
Publikováno v:
Acta crystallographica. Section F, Structural biology communications. 72(Pt 12)
The structure of Msmeg_6760, a protein of unknown function, has been determined. Biochemical and bioinformatics analyses determined that Msmeg_6760 interacts with a protein encoded in the same operon, Msmeg_6762, and predicted that the operon is a to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7995db532e830ac878a1a4d43098782e
https://pubmed.ncbi.nlm.nih.gov/27917833
https://pubmed.ncbi.nlm.nih.gov/27917833
Publikováno v:
Protein Science. 21:1754-1767
VapBC pairs account for 45 out of 88 identified toxin-antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::226418ac0412e6292bbf49cdbc080f22
https://doi.org/10.1002/pro.2161
https://doi.org/10.1002/pro.2161
Autor:
Linda Miallau, Gordon A. Leonard, Sean McSweeney, William N. Hunter, Justyna Kalinowska-Tłuścik, Mads Gabrielsen
Publikováno v:
Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:237-241
4-Diphosphocytidyl-2C-methyl-d-erythritol kinase (IspE; EC 2.7.1.148) contributes to the 1-deoxy-d-xylulose 5-phosphate or mevalonate-independent biosynthetic pathway that produces the isomers isopentenyl diphosphate and dimethylallyl diphosphate. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb16e522e61713c1dab99c94a0ec6c2
https://doi.org/10.1107/s1744309109054591
https://doi.org/10.1107/s1744309109054591
Autor:
Mark A. Arbing, Michael Faller, Duilio Cascio, Feng Guo, Linda Miallau, Janet Chiang, David Eisenberg
Publikováno v:
Journal of Biological Chemistry. 284:276-283
In prokaryotes, cognate toxin-antitoxin pairs have long been known, but no three-dimensional structure has been available for any given complex from Mycobacterium tuberculosis. Here we report the crystal structure and activity of a member of the VapB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f19742b5d803d4b7706310ba11c81b3a
https://doi.org/10.1074/jbc.m805061200
https://doi.org/10.1074/jbc.m805061200
Autor:
Andrew B, Min, Linda, Miallau, Michael R, Sawaya, Jeff, Habel, Duilio, Cascio, David, Eisenberg
Publikováno v:
Protein science : a publication of the Protein Society. 21(11)
VapBC pairs account for 45 out of 88 identified toxin-antitoxin (TA) pairs in the Mycobacterium tuberculosis (Mtb) H37Rv genome. A working model suggests that under times of stress, antitoxin molecules are degraded, releasing the toxins to slow the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a695c4b63e77402542239e1cb774088
https://pubmed.ncbi.nlm.nih.gov/23011806
https://pubmed.ncbi.nlm.nih.gov/23011806
Autor:
Nicholas Chim, Edward N. Baker, Celia W. Goulding, Li-Wei Hung, Inna Krieger, Stephanie Swanson, Hongye Li, Thomas C. Terwilliger, Jodie M. Johnston, J. Shaun Lott, Esther M. M. Bulloch, John B. Bruning, Linda Miallau, Robert P. Morse, David Eisenberg, R. Sankaranarayanan, Michael N.G. James, Jeff E. Habel, Haelee Kim, Alexandra Manos-Turvey, Richard J. Payne, Chang-Yub Kim, James C. Sacchettini
Publikováno v:
Tuberculosis (Edinburgh, Scotland). 91(2)
The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ab7922dbc7c8f5e6dac737b0a54eed
https://pubmed.ncbi.nlm.nih.gov/21247804
https://pubmed.ncbi.nlm.nih.gov/21247804
Publikováno v:
The Journal of biological chemistry. 282(27)
High resolution structures of Staphylococcus aureus d-tagatose-6-phosphate kinase (LacC) in two crystal forms are herein reported. The structures define LacC in apoform, in binary complexes with ADP or the co-factor analogue AMP-PNP, and in a ternary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5763c226a1028d6afc87b52c592f645
https://pubmed.ncbi.nlm.nih.gov/17459874
https://pubmed.ncbi.nlm.nih.gov/17459874
Autor:
Felix Rohdich, William N. Hunter, Wolfgang Eisenreich, Stefan Hecht, Sean McSweeney, Linda Miallau, Gordon A. Leonard, Adelbert Bacher, Magnus S. Alphey, Lauris E. Kemp
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(16)
4-Diphosphocytidyl-2 C -methyl- d -erythritol kinase, an essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis, catalyzes the single ATP-dependent phosphorylation stage affording 4-diphosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1484d3ee898055be5d03c90a7c17fc21
https://pubmed.ncbi.nlm.nih.gov/12878729
https://pubmed.ncbi.nlm.nih.gov/12878729