Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Linda Merkel"'
Autor:
Mark H. Perrone, Bruno X. Boutouyrie, Kenneth L. Clark, Linda Merkel, Michael F. Kelley, Peter N. Zannikos
Publikováno v:
Cardiovascular Drug Reviews. 18:183-210
The discovery that the endogenous autocoid adenosine plays a role in the ability of the myocardium to protect itself against ischemia has prompted a significant effort to identify stable cardioprotective adenosine agonists. This review summarizes cur
Autor:
Robert J. Leadley, Charles Kasiewski, Tara Wentz, Glenda E. Bilder, Jeffery Bostwick, Mark H. Perrone, Saul J. Needle, Betsey O’Conner, Christopher T. Dunwiddie, Lisa Byan, Kenneth Page, Helen Galczenski, Linda Merkel, Persons Paul E, Myers Michael R, Alfred P. Spada, Amin Dilip, Cuong Ly
Publikováno v:
Circulation. 99:3292-3299
Background —Platelet-derived growth factor (PDGF), a purported mediator of arterial response to injury, stimulates proliferation, chemotaxis, and matrix production by activation of its membrane receptor tyrosine kinase. Because these activities und
Autor:
Alfred P. Spada, Mark H. Perrone, Fink Cynthia A, Kenneth L. Clark, Bryan F. Cox, Michael F. Jarvis, Glenn J. Smits, Camilo J. Rojas, Linda Merkel
Publikováno v:
Drug Development Research. 45:30-43
AMP 579 1S-[1α,2β,3β,4α(S*)]-4-[7-[[1 -[(3-chloro-2-thienyl)methyl]propylamino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxy cyclopentanecarboxamide) is a novel cardioprotective adenosine agonist with the following order of affinity at ad
Autor:
Saul J. Needle, Amin Dilip, Sheng Yuh Tang, Glenda E. Bilder, Helen Galczenski, Linda Merkel, Donald Lewis, Camilo J. Rojas, Mark H. Perrone, Marie M. Gleason
Publikováno v:
Steroids. 60:475-483
Two separate enzymatic assays were developed in order to test the selectivity of inhibitors in cholesterol biosynthesis. One assay detects inhibition of delta 5.7-sterol delta 7-reductase, the enzyme involved in the conversion of 7-dehydrocholesterol
Autor:
Bryan F. Cox, Mark H. Perrone, E.D. Hawkins, Linda Merkel, D.J. Colussi, B.D. Greenland, Glenn J. Smits
Publikováno v:
Pharmacology. 51:224-236
Adenosine is known to produce cardiovascular effects such as bradycardia and hypotension via activation of myocardial (A1) and vascular (A2) receptors and antilipolytic effects through activation of adipocyte (A1) receptors. We established the cardio
Publikováno v:
British Journal of Pharmacology. 111:1233-1239
1. The effects of myocardial ischaemia/reperfusion were tested on the coronary vasorelaxant responses to agonists selective for the A1 and A2 adenosine receptor subtypes in the dog. The left anterior descending (LAD) coronary artery was occluded dist
Autor:
Linda Merkel
Publikováno v:
Cardiovascular Drug Reviews. 11:501-515
Publikováno v:
Nucleosides and Nucleotides. 11:1077-1088
This report describes the preparation of (R)-(3-chloro-2-thienyl)-2-butylamine and its conversion to the titled N6-substituted adenosine agonist, RG 14718(−). RG 14718(−) was found to have exceptional affinity and selectivity for the adenosine A1
Publikováno v:
European Journal of Pharmacology. 216:29-35
We have examined the interaction of zaprinast, a selective inhibitor of cGMP phosphodiesterase, with guanylate cyclase activators on vascular smooth muscle relaxation in vitro and in vivo. Isolated porcine coronary arterial rings precontracted with p
Autor:
Linda Hamel, Mark H. Perrone, Kenneth L. Clark, Asher Zilberstein, Margaret Kenney, Al Spada, Camilo J. Rojas, J. M. Kaplow, Ali Ardati, Zaid Jayyosi, Linda Merkel
Publikováno v:
Cell stresschaperones. 5(2)
This study characterizes Hsp70 induction in human smooth muscle cells (SMC) by herbimycin A and cyclopentenone prostaglandins. The magnitude of Hsp70 induction by cyclopentenone prostaglandins was 8- to 10-fold higher than induction by herbimycin A.