Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Linda Maureen O'bryan"'
Autor:
Linda Maureen O'bryan, Erica L. Clinkenbeard, Martin S. Cramer, Pu Ni, Robert L. Johnson, Manoj Bhaskaran, Arun K. Tatiparthi, Jonathan M. Wilson, Julia M. Hum, Kenneth E. White, Rosamund C. Smith
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 126(4)
Diabetic nephropathy (DN) is a primary cause of end-stage renal disease and is becoming more prevalent because of the global rise in type 2 diabetes. A model of DN, the db/db uninephrectomized ( db/db-uni) mouse, is characterized by obesity, as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f506b699af54de2a8d6792f25376156
https://pubmed.ncbi.nlm.nih.gov/30605400
https://pubmed.ncbi.nlm.nih.gov/30605400
A significant portion of the key biological functions of αKlotho (αKL) and its cognate ligand Fibroblast growth factor-23 (FGF23) have been revealed through the study of rare diseases of mineral metabolism. These findings have far reaching implicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d3dcaddb7dd0b902a17e402308df0a
https://europepmc.org/articles/PMC5441975/
https://europepmc.org/articles/PMC5441975/
Autor:
Arun K. Tatiparthi, Robert L. Johnson, Erica L. Clinkenbeard, Martin S. Cramer, Manoj Bhaskaran, Linda Maureen O'bryan, Rosamund Carol Smith, Kenneth E. White, Jonathan M. Wilson, Taryn A. Cass, Julia M. Hum
Publikováno v:
Journal of the American Society of Nephrology : JASN. 28(4)
αKlotho (αKL) regulates mineral metabolism, and diseases associated with αKL deficiency are characterized by hyperphosphatemia and vascular calcification (VC). αKL is expressed as a membrane-bound protein (mKL) and recognized as the coreceptor fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2efb5613c3426da0aac844c074e86c
https://pubmed.ncbi.nlm.nih.gov/27837149
https://pubmed.ncbi.nlm.nih.gov/27837149
Autor:
Y. Linda Ma, Taryn A. Cass, Emily G. Farrow, Haijun Sun, Erica L. Clinkenbeard, Joy K. Saha, Jonathan M. Wilson, David B. Burr, Jessica L. Roberts, Lelia J. Summers, Kenneth E. White, Rosamund C. Smith, Alexei Kharitonenkov, Carol L. Broderick, Qing Qiang Zeng, Matthew R. Allen, Qianxu Guo, Linda Maureen O'bryan, Matthew D. Breyer
The FGF23 coreceptor αKlotho (αKL) is expressed as a membrane-bound protein (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate intracellular signaling. It also circulates as an endoproteolytic cleavage product of mKL (cKL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433cb1362b254fd16cd42fe8b9c58f82
https://europepmc.org/articles/PMC3533557/
https://europepmc.org/articles/PMC3533557/
Autor:
Jirong Lu, Jonathan M. Wilson, Jeffrey C. Hanson, Kalpana M. Merchant, Donmienne Doen Mun Leung, Lihua Huang, Michael J. O'Neill, Sandra Sossick, Jane Cooper, Rosamund C. Smith, Linda Maureen O'bryan, Ghanem Mahmoud, Pamela Jean Mitchell
Publikováno v:
Experimental Neurology. :165-176
Several lines of evidence indicate that Glial cell line-derived neurotrophic factor (GDNF) is a trophic factor for dopaminergic neurons. Direct parenchymal administration of GDNF is robustly neuroprotective and neurorestorative in multiple neurotoxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baf8ddf3db8bd6a61688cf8bd7a3e19