Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Linda Marcus"'
Autor:
Robert Francis Kester, Linda Marcus, Marek M. Kabat, Lida Qi, Wang Ka, Michael Pignatello, Wendy Lea Corbett, Cheryl Spence, Franz M. Matschinsky, Lisa M. Garofalo, Roumen Nikolaev Radinov, Ramakanth Sarabu, David J Moore, Yi Ren, Nancy-Ellen Haynes, Zhenmin Liang, Fred Thomas Bizzarro, Darryl W. Hilliard, John Tengi, Wanping Geng, Stanley D. Hutchings, Thomas G. Steele, Joseph Grimsby, Mark T. Dvorozniak, Joseph F. Grippo, Kevin Richard Guertin, Paige Erin Mahaney, Jagdish Kumar Racha
Publikováno v:
Journal of Medicinal Chemistry. 55:7021-7036
Glucokinase (GK) activation as a potential strategy to treat type 2 diabetes (T2D) is well recognized. Compound 1, a glucokinase activator (GKA) lead that we have previously disclosed, caused reversible hepatic lipidosis in repeat-dose toxicology stu
Autor:
Ramakanth Sarabu, Jianping Lou, Achyutharao Sidduri, David J Moore, Jagdish Kumar Racha, Joseph Grimsby, Wendy Lea Corbett, Cheryl Spence, Robert Francis Kester, Linda Marcus, Mark T. Dvorozniak, Joseph F. Grippo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5673-5676
The phenylacetamide 1 represents the archtypical glucokinase activator (GKA) in which only the R -isomer is active. In order to probe whether the chiral center could be replaced, we prepared a series of olefins 2 and show in the present work that the
Publikováno v:
Journal of Broadcasting & Electronic Media. 45:290-302
This study examined the shift away from traditional public affairs reporting toward sensationalism on the network evening news between 1968 and 1996. Using methods developed by Adams (1978) and extended by Slattery and Hakanen (1994), this study foun
Autor:
Lida Qi, John Tengi, Robert Francis Kester, Kevin Richard Guertin, Linda Marcus, Cheryl Spence, Nancy-Ellen Haynes, Fred Thomas Bizzarro, Paige Erin Mahaney, Joseph Grimsby, Mark A. Magnuson, Mark T. Dvorozniak, Franz M. Matschinsky, Wendy Lea Corbett, Chang An Chu, Joseph F. Grippo, John W. Coffey, Ramakanth Sarabu, Darryl W. Hilliard
Publikováno v:
Science (New York, N.Y.). 301(5631)
Glucokinase (GK) plays a key role in whole-body glucose homeostasis by catalyzing the phosphorylation of glucose in cells that express this enzyme, such as pancreatic β cells and hepatocytes. We describe a class of antidiabetic agents that act as no