Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Linda M. Pullan"'
Publikováno v:
Journal of Neurochemistry. 59:2087-2093
Neomycin appears as a full agonist and spermidine as a partial agonist at the site where polyamines enhance 1-[1-(2-thienyl)cyclohexyl][3H]piperidine ([3H]TCP) binding on the N-methyl-D-aspartate (NMDA) receptor. Other aminoglycosides also enhance [3
Autor:
David C. U'Prichard, Linda M. Pullan
Publikováno v:
Research-Technology Management. 40:35-39
Today's drug discovery research organization must consider what the healthcare business will look like in 2015. David C. U'Prichard and Linda M. Pullan OVERVIEW: Increased cost pressures, more informative and expensive clinical data, and many competi
Autor:
Christopher H. Sotak, Marc Fisher, Andreas Bergmann, Thomas M. Bare, James E. Formato, Richard A.D. Carano, Linda M. Pullan, Turgut Tatlisumak, Kentaro Takano
Publikováno v:
Stroke. 28:1255-1263
Background and Purpose The glycine site on the N -methyl- d -aspartate (NMDA) receptor complex offers a therapeutic target for acute focal ischemia, potentially devoid of most side effects associated with competitive and noncompetitive NMDA antagonis
Autor:
Linda M. Pullan, Jeffrey M. Goldstein, James R. Damewood, Paul F. Jackson, Jeffrey A. McKinney, Timothy Davenport, Gregory G. Harris, Laura Garcia, Margaret G. Melville, Marc J. Chapdelaine
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:3097-3100
A series of 4-arylbenz[b]azepine analogs were prepared and shown to act as antagonists at the strychnine-insensitive glycine receptor. The heteroaryl substituted benz[b]azepine derivative 11 also showed excellent in vivo activity.
Autor:
Linda M. Pullan, Clyde W. Draper, Jitendra Patel, Thomas M. Bare, Jitendra B. Patel, Charles D. McLaren
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:55-60
A series of novel spiroisoindolines was designed and synthesized as potential noncompetitive NMDA antagonists. Affinities of these compounds for the noncompetitive NMDA binding site were determined using [3H]TCP and found to possess IC50s ranging fro
Autor:
Timothy Davenport, Paul F. Jackson, Gregory G. Harris, Laura Garcia, Jeffrey A. McKinney, James R. Damewood, Linda M. Pullan, Marc J. Chapdelaine, Margaret G. Melville, Jeffrey M. Goldstein
Publikováno v:
ChemInform. 27
A series of 4-arylbenz[b]azepine analogs were prepared and shown to act as antagonists at the strychnine-insensitive glycine receptor. The heteroaryl substituted benz[b]azepine derivative 11 also showed excellent in vivo activity.
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 208:25-29
HA-966 (1-hydroxy-3-amino-pyrrolid-2-one), an antagonist at the strychine-insensitive glycine site on the N-methyl-D-aspartate (NMDA) receptor complex, only partially inhibits the binding of noncompetitive antagonists to the NMDA receptor but enhance
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:751-756
The synthesis of a series of tricyclic quinoxalines is described. These compounds exhibit good affinity for both the strychnine-insensitive glycine site of the NMDA receptor and the AMPA receptor.
Autor:
Andre I. Salama, D. LaMonte, Thomas J. Mangano, Jitendra Patel, P. J. Warwick, William C. Zinkand, R. J. Powel, Richard A. Keith, M. Britt, Linda M. Pullan, Robert J. Stumpo, M. J. Chapdelaine
Publikováno v:
Journal of Neurochemistry. 55:1346-1351
HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is chiral. We report stereoselectivity for the (R)-enan
Publikováno v:
Journal of Autonomic Pharmacology. 10:213-220
1. The effects of the polyamines, spermine and spermidine on neuronal N-type voltage-sensitive calcium channels were investigated using the binding and function of the ligand omega-conotoxin GVIA (omega-CT). 2. Spermine and spermidine enhanced (EC50