Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Linda M. Muul"'
Autor:
Sally Shupien, Linda M. Muul, Fabio Candotti, Berkley Brown, Pei Yu Fu, Rob Sokolic, Barbara Nowicki, Otto O. Yang, Aaron R. Cooper, Andrew M. Scharenberg, Christopher Silvin, David W. Gjertson, Alejandra Davila, Kit L. Shaw, Dayna Terrazas, Donald B. Kohn, Alan Ikeda, Beatriz Campo Fernandez, Radha G. Rishi, Neena Kapoor, Xiaoyan Wang, Denise Carbonaro, Suparna Mishra, Arumugam Balamurugan, G. Jayashree Jagadeesh, Satiro N. De Oliveira, Yeong Choi, Kenneth Cornetta, Suzanne Skoda-Smith, Michael S. Hershfield, Roshini S. Abraham, Sabine Geiger, David Buchbinder, Barbara C. Engel, Provaboti Barman, Theodore B. Moore, Kathey Mohan, E. Monika Smogorzewska, Elizabeth Garabedian, Allen Yu, Ken Purdy, John Tse, Greg M. Podsakoff, Stacie M. Anderson
Publikováno v:
Journal of Clinical Investigation. 127:1689-1699
Background Autologous hematopoietic stem cell transplantation (HSCT) of gene-modified cells is an alternative to enzyme replacement therapy (ERT) and allogeneic HSCT that has shown clinical benefit for adenosine deaminase-deficient (ADA-deficient) SC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7495591a0b8eb59cc66fe20e2a54576
https://doi.org/10.1172/jci90367
https://doi.org/10.1172/jci90367
Autor:
Daniele Moratto, Qing Yan, Fabio Candotti, R. Michael Blaese, Linda M. Muul, Kumar Felix, Jacquelin H. Bui, Brian R. Davis, Nicole L. Prokopishyn
Publikováno v:
Clinical Immunology. 135:72-83
The reasons underlying the occurrence of multiple revertant genotypes in Wiskott-Aldrich syndrome (WAS) patients remain unclear. We have identified more than 30 revertant genotypes in a C995T WAS patient having 10-15% revertant, WAS protein (WASp)-ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a3e10d9aafc631f762fa2820388f83
https://doi.org/10.1016/j.clim.2009.12.011
https://doi.org/10.1016/j.clim.2009.12.011
Autor:
Fabio Candotti, Linda M. Muul, Nicole L. Prokopishyn, Daniele Moratto, Michael DiCola, Brian R. Davis, Jonathan B. Rosenberg, R. Michael Blaese
Publikováno v:
Blood. 111:5064-5067
Spontaneous somatic reversions of inherited mutations are poorly understood phenomena that are thought to occur uncommonly in a variety of genetic disorders. When molecularly characterized, revertant cells have rarely exhibited more than one revertan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebb132b0f0d2f4c444d83b9034e6c14
https://doi.org/10.1182/blood-2007-06-095299
https://doi.org/10.1182/blood-2007-06-095299
Autor:
Linda M. Muul, Fabio Candotti
Publikováno v:
Current Gene Therapy. 7:361-368
Gene-modified T cells were the first gene therapy tool used in clinical gene transfer trials. After the first applications in immunodeficiency diseases, T cell gene therapy has been extended to HIV infection and cancer. The primary obstacle to succes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f0f746decf9accb9afa004d497906c
https://doi.org/10.2174/156652307782151489
https://doi.org/10.2174/156652307782151489
Autor:
Ajit Varki, Fabio Candotti, Amy S. Rosenberg, Kazuhide Tsuji, Walter J. Urba, Joan K. Lunney, Linda M. Muul, Ann M. Lawler, Norihisa Sakamoto, Jorge A. Tavel, H. Clifford Lane, Emanuel F. Petricoin, Julia A. Metcalf, Bernard A. Fox
Publikováno v:
Blood. 110:501-508
Recent studies have demonstrated that cell populations intended for therapeutic purposes that are cultured in heterologous animal products can acquire xenoantigens, potentially limiting their utility. In investigations of the immune response to murin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22e967160af8e1ae58b24b7c8f28bd8
https://doi.org/10.1182/blood-2007-01-066522
https://doi.org/10.1182/blood-2007-01-066522
Publikováno v:
Arthritis & Rheumatism. 56:2936-2946
Objective Interleukin-17 (IL-17)–producing T helper cells have been proposed to represent a separate lineage of CD4+ cells, designated Th17 cells, which are regulated by the transcription factor retinoic acid–related orphan receptor γt (RORγt).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50211a0adda8239b25322dfac12e4265
https://doi.org/10.1002/art.22866
https://doi.org/10.1002/art.22866
Publikováno v:
Human Gene Therapy. 13:1605-1610
The first approved clinical gene therapy trial for adenosine deaminase (ADA) deficiency employed autologous T cells grown in fetal calf serum (FCS)-supplemented medium and transduced with a retroviral vector (LASN) also produced in the presence of FC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e164f564393958578882dd8c7df688
https://doi.org/10.1089/10430340260201699
https://doi.org/10.1089/10430340260201699
Autor:
Michael S. Hershfield, Makoto Otsu, Laura M. Tuschong, Linda M. Muul, Yukio Sakiyama, Masafumi Onodera, Tadashi Ariga, Fabio Candotti
Publikováno v:
Human Gene Therapy. 13:425-432
Clinical gene therapy trials for adenosine deaminase (ADA) deficiency have shown limited success of corrective gene transfer into autologous T lymphocytes and CD34(+) cells. In these trials, the levels of gene transduction and expression in hematopoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3176b79d5ff352b85091dc6c10e1a85
https://doi.org/10.1089/10430340252792558
https://doi.org/10.1089/10430340252792558
Autor:
E. R. Kaminski, Thomas A. Fleisher, Fabio Candotti, Linda M. Muul, David M. Frucht, Kazuki Takada, Ivona Aksentijevich, Paul Veys, John J. O'Shea, Grace G. Morgan, G Perham, G J Jagadeesh, Lucia Dora Notarangelo, Eja Gerritsen, Patrizia Mella, Massimo Gadina, Jjh Bleesing, Joel Nelson, Richard Fabian Schumacher
Publikováno v:
Genes & Immunity. 2:422-432
Mutations of the Janus kinase 3 (JAK3) have been previously described to cause an autosomal recessive variant of severe combined immunodeficiency (SCID) usually characterized by the near absence of T and NK cells, but preserved numbers of B lymphocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe65a2d04056ab1834ce1c95d52991a
https://doi.org/10.1038/sj.gene.6363802
https://doi.org/10.1038/sj.gene.6363802
Autor:
Yutaka Hanazono, Richard W. Childs, Stephanie Sellers, Neelam Giri, Brian A. Agricola, Mark E. Metzger, Cynthia E. Dunbar, Dominik A. Heim, John F. Tisdale, Robert E. Donahue, Linda M. Muul, Tong Wu
Publikováno v:
Molecular Therapy. 1:533-544
Host immune responses against foreign transgenes may be a major obstacle to successful gene therapy. To clarify the impact of an immune response to foreign transgene products on the survival of genetically modified cells, we studied the in vivo persi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b1a65a4c9e87f97b3657d8c1fc2d71
https://doi.org/10.1006/mthe.2000.0072
https://doi.org/10.1006/mthe.2000.0072