Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Linda M Slot"'
Autor:
Linda M Slot, Rochelle D Vergroesen, Priscilla F Kerkman, Ellen Staudinger, Sanne Reijm, Hugo J van Dooren, Ellen I H van der Voort, Tom W J Huizinga, René E M Toes, Hans U Scherer
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247847 (2021)
Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1% of the world population. RA is associated with the presence of autoantibodies, of which anti-citrullinated protein antibodies (ACPA) are most prominent. ACPA are produced by citru
Externí odkaz:
https://doaj.org/article/f4bdb0806e0240eab920cc577bc62025
Autor:
Rochelle D. Vergroesen, Linda M. Slot, Barbera D. C. van Schaik, Marvyn T. Koning, Theo Rispens, Antoine H. C. van Kampen, René E. M. Toes, Hans U. Scherer
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Many autoimmune diseases are hallmarked by autoreactive B and plasma cell responses that are directly or indirectly involved in disease pathogenesis. These B-cell responses show large variability between diseases, both in terms of the secreted autoan
Externí odkaz:
https://doaj.org/article/c7729ac6a2de4397b5caba227729b47e
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
Autor:
Yibo He, Changrong Ge, Àlex Moreno-Giró, Bingze Xu, Christian M. Beusch, Katalin Sandor, Jie Su, Lei Cheng, Erik Lönnblom, Christina Lundqvist, Linda M. Slot, Dongmei Tong, Vilma Urbonaviciute, Bibo Liang, Taotao Li, Gonzalo Fernandez Lahore, Mike Aoun, Vivianne Malmström, Theo Rispens, Patrik Ernfors, Camilla I. Svensson, Hans Ulrich Scherer, René E. M. Toes, Inger Gjertsson, Olov Ekwall, Roman A. Zubarev, Rikard Holmdahl
Publikováno v:
Nature communications, 14(1):691. Nature Publishing Group
Nature Communications, 14(1). NATURE PORTFOLIO
Nature Communications, 14(1). NATURE PORTFOLIO
Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we have expressed monoclonal ACPAs derived from patients with RA, a
Autor:
Richard J Bende, Linda M Slot, Mark J Kwakkenbos, Thera AM Wormhoudt, Aldo Jongejan, Gwenny M Verstappen, Antoine CM van Kampen, Jeroen EJ Guikema, Frans GM Kroese, Carel JM van Noesel
Publikováno v:
Journal of pathology. John Wiley and Sons Ltd
We recently demonstrated that normal memory B lymphocytes carry a substantial number of de novo mutations in the genome. Here, we performed exome-wide somatic mutation analyses of bona fide autoreactive rheumatoid factor (RF)-expressing memory B cell
Autor:
Tommaso Andreani, Linda M Slot, Samuel Gabillard, Carsten Strübing, Claus Reimertz, Veeranagouda Yaligara, Aleida M Bakker, Reza Olfati-Saber, René E M Toes, Hans U Scherer, Franck Augé, Deimantė Šimaitė
Publikováno v:
NAR Genomics and Bioinformatics, 4(3). OXFORD UNIV PRESS
Multiple methods have recently been developed to reconstruct full-length B-cell receptors (BCRs) from single-cell RNA-seq (scRNA-seq) data. This need emerged from the expansion of scRNA-seq techniques, the increasing interest in antibody-based drug d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ca47733ed09f7589183d35ac2a950c
https://hdl.handle.net/1887/3562178
https://hdl.handle.net/1887/3562178
Autor:
M. Reth, E W N Levarht, Hans Scherer, J.C. Kwekkeboom, J. W. Drijfhout, Holger Bang, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Arieke S. B. Kampstra, George M.C. Janssen, P.A. van Veelen, Marco Cavallari, Corrie M. Wortel, Rem Toes, Twj Huizinga, Theresa Kissel, Rochelle D Vergroesen, Kimberly M. Bonger, Linda M. Slot
Publikováno v:
Annals of the rheumatic diseases, 79(4):216499, 472-480. BMJ Publishing Group
Annals of the Rheumatic Diseases, 79, 472-480
Annals of the Rheumatic Diseases, 79, 4, pp. 472-480
Annals of the Rheumatic Diseases, 79(4), 472-480. BMJ PUBLISHING GROUP
Annals of the rheumatic disease
Annals of the Rheumatic Diseases, 79, 472-480
Annals of the Rheumatic Diseases, 79, 4, pp. 472-480
Annals of the Rheumatic Diseases, 79(4), 472-480. BMJ PUBLISHING GROUP
Annals of the rheumatic disease
ObjectiveAutoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid arthritis (RA). The relation between these anti-modified protein antib
Autor:
Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Linda M. Slot, Marco Cavallari, Yibo He, Karin A. van Schie, Rochelle D. Vergroesen, Arieke S.B. Kampstra, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Carolien Koeleman, Lennard M. Voortman, Laura H. Heitman, Bingze Xu, Ger J.M. Pruijn, Manfred Wuhrer, Theo Rispens, Tom W.J. Huizinga, Hans Ulrich Scherer, Michael Reth, Rikard Holmdahl, Rene E.M. Toes
Publikováno v:
Science Advances, 8, 6, pp. 1-21
Science Advances, 8, 1-21
Science advances, 8(6):abm1759. American Association for the Advancement of Science
Kissel, T, Ge, C, Hafkenscheid, L, Kwekkeboom, J C, Slot, L M, Cavallari, M, He, Y, van Schie, K A, Vergroesen, R D, Kampstra, A S B, Reijm, S, Stoeken-Rijsbergen, G, Koeleman, C, Voortman, L M, Heitman, L H, Xu, B, Pruijn, G J M, Wuhrer, M, Rispens, T, Huizinga, T W J, Scherer, H U, Reth, M, Holmdahl, R & Toes, R E M 2022, ' Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation ', Science Advances, vol. 8, no. 6, abm1759 . https://doi.org/10.1126/sciadv.abm1759
Science Advances, 8(6). AMER ASSOC ADVANCEMENT SCIENCE
Science Advances, 8(6), 1-21
Science Advances, 8, 1-21
Science advances, 8(6):abm1759. American Association for the Advancement of Science
Kissel, T, Ge, C, Hafkenscheid, L, Kwekkeboom, J C, Slot, L M, Cavallari, M, He, Y, van Schie, K A, Vergroesen, R D, Kampstra, A S B, Reijm, S, Stoeken-Rijsbergen, G, Koeleman, C, Voortman, L M, Heitman, L H, Xu, B, Pruijn, G J M, Wuhrer, M, Rispens, T, Huizinga, T W J, Scherer, H U, Reth, M, Holmdahl, R & Toes, R E M 2022, ' Surface Ig variable domain glycosylation affects autoantigen binding and acts as threshold for human autoreactive B cell activation ', Science Advances, vol. 8, no. 6, abm1759 . https://doi.org/10.1126/sciadv.abm1759
Science Advances, 8(6). AMER ASSOC ADVANCEMENT SCIENCE
Science Advances, 8(6), 1-21
The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain glycans (VDGs). Their abundant occurrence results from the selective introduction of N-linked glycosylation sites during somatic hypermutation, and their presenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0208285deb500549af186c437aedd773
https://repository.ubn.ru.nl/handle/2066/248660
https://repository.ubn.ru.nl/handle/2066/248660
Autor:
Veerle F. A. M. Derksen, Theo Rispens, Holger Bang, Jan W. Drijfhout, Pleuni Ooijevaar-de Heer, Sanne Reijm, René E. M. Toes, Nivine E. W. Levarht, Hans Scherer, Leendert A. Trouw, Gerrie Stoeken-Rijsbergen, Corrie M. Wortel, Tom W J Huizinga, Linda M. Slot, Hugo J. van Dooren, Arieke S. B. Kampstra, Theresa Kissel
Publikováno v:
Arthritis Research and Therapy, 23(1). BMC
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid arthritis (RA). Although AMPA-IgG cross-reactivity to multiple post-translational modifications (PTMs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1502e82abff52ec3d8523d897b4f25
https://hdl.handle.net/1887/3240261
https://hdl.handle.net/1887/3240261
Autor:
Jeroen E. J. Guikema, Koen Wagner, M. J. Kwakkenbos, Aldo Jongejan, C. J. M. Van Noesel, Richard J. Bende, Thera A. M. Wormhoudt, A. C. M. van Kampen, Linda M. Slot, Aranka V Ballering
Publikováno v:
Leukemia, 33(5), 1219-1230. Nature Publishing Group
In the past years, the genomes of thousands of tumors have been elucidated. To date however, our knowledge on somatic gene alterations in normal cells is very limited. In this study, we demonstrate that tetanus-specific human memory B lymphocytes car
Autor:
L.E. Burgers, Robin M. ten Brinck, Hergen Spits, Ellen I. H. van der Voort, Annette H M van der Helm-van Mil, A Bakker, Priscilla F Kerkman, René E. M. Toes, Dominique Baeten, Hans Scherer, Nienke J. Blomberg, Hendy Kristyanto, Tom W J Huizinga, Linda M. Slot
Publikováno v:
Science Translational Medicine, 12(570). AMER ASSOC ADVANCEMENT SCIENCE
Science translational medicine, 12(570):aaz5327. American Association for the Advancement of Science
SCIENCE TRANSLATIONAL MEDICINE
Science translational medicine, 12(570):aaz5327. American Association for the Advancement of Science
SCIENCE TRANSLATIONAL MEDICINE
Autoreactive B cells mediate autoimmune pathology, but exactly how remains unknown. A hallmark of rheumatoid arthritis (RA), a common autoimmune disease, is the presence of disease-specific anticitrullinated protein antibodies (ACPAs). Here, we showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d74acddf2b200725f93641159014bb
http://hdl.handle.net/1887/3182270
http://hdl.handle.net/1887/3182270