Mucin Muc2 deficiency and weaning influences the expression of the innate defense genes Reg3β, Reg3γ and angiogenin-4.

Autor: Nanda Burger-van Paassen, Linda M P Loonen, Janneke Witte-Bouma, Anita M Korteland-van Male, Adrianus C J M de Bruijn, Maria van der Sluis, Peng Lu, Johannes B Van Goudoever, Jerry M Wells, Jan Dekker, Isabelle Van Seuningen, Ingrid B Renes

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e38798 (2012)

BACKGROUND: Mucin Muc2 is the structural component of the intestinal mucus layer. Absence of Muc2 leads to loss of this layer allowing direct bacterial-epithelial interactions. We hypothesized that absence of the mucus layer leads to increased expres

Externí odkaz: https://doaj.org/article/f2c65b3c92b742f7a4104be5afd25d40

Aryl hydrocarbon Receptor activation during In vitro and in vivo digestion of raw and cooked broccoli (brassica oleracea var. Italica)

Autor: Ian Rowland, Vincenzo Fogliano, Gema Pereira-Caro, Edoardo Capuano, Chris I R Gill, Jonna E. B. Koper, L. Kirsty Pourshahidi, Jerry M. Wells, Gordon J. McDougall, Zhan Huang, Maaike Kortekaas, Linda M. P. Loonen

Publikováno v: Food and Function, 11(5), 4026-4037
Food and Function 11 (2020) 5

Broccoli is rich in glucosinolates, which can be converted upon chewing and processing into Aryl hydrocarbon Receptor (AhR) ligands. Activation of AhR plays an important role in overall gut homeostasis but the role of broccoli processing on the gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8170d0255057ce7f84408fa4e252c49
https://research.wur.nl/en/publications/aryl-hydrocarbon-receptor-activation-during-in-vitro-and-in-vivo-

A8 DIETARY TRYPTOPHAN MODULATES KYNURENINE AND INDOLE PRODUCTION IN HEALTHY INDIVIDUALS

Autor: Rajka Borojevic, Linda M. P. Loonen, Andrea Nardelli, Marco Constante, Premysl Bercik, Natalia Causada-Calo, Gaston Rueda, Elena F. Verdu, Jerry M. Wells, Harry Sokol

Publikováno v: Journal of the Canadian Association of Gastroenterology. 4:9-10

Background Tryptophan is an essential amino acid that is transformed by host and gut microbial enzymes into multiple bioactive metabolites that regulate immunity, mood and circadian rhythms. In particular, indoles, produced by gut bacterial metabolis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cefb855a9437abefae1704c8097ae26d
https://doi.org/10.1093/jcag/gwab002.007

Identification of Commensal Species Positively Correlated with Early Stress Responses to a Compromised Mucus Barrier

Autor: Bruno Sovran, Linda M. P. Loonen, Floor Hugenholtz, Paul de Vos, Michiel Kleerebezem, Jerry M. Wells, Clara Belzer, Ellen H. Stolte, Hauke Smidt, Peter van Baarlen, Mark V. Boekschoten, Peng Lu, Jan P. Dekker, Ingrid B. Renes

Publikováno v: Inflammatory Bowel Diseases, 22(4), 826-840. LIPPINCOTT WILLIAMS & WILKINS
Inflammatory Bowel Diseases, 22(4), 826-840
Inflammatory Bowel Diseases, 22(4), 826-840. Oxford University Press
Inflammatory bowel diseases, 22(4), 826-840. John Wiley and Sons Inc.
Inflammatory Bowel Diseases 22 (2016) 4

Background: Our aims were (1) to correlate changes in the microbiota to intestinal gene expression before and during the development of colitis in Muc2(-/-) mice and (2) to investigate whether the heterozygote Muc2(+/-) mouse would reveal host marker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a01855cda063979d7da31d71f34b71
https://doi.org/10.1097/mib.0000000000000688

Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids

Autor: Jerry M. Wells, B. van der Hee, Linda M. P. Loonen, Nico Taverne, Hauke Smidt, J.J. Taverne-Thiele

Publikováno v: Stem Cell Research 28 (2018)
Stem Cell Research, Vol 28, Iss, Pp 165-171 (2018)
Stem Cell Research, 28, 165-171

An important practical limitation of the three-dimensional geometry of stem-cell derived intestinal organoids is that it prevents easy access to the apical epithelium for testing food components, microorganisms, bioactive and toxic compounds. To this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61672d6c83345c6e4cc2672d3ec1415d
https://pubmed.ncbi.nlm.nih.gov/29499500