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of 10
pro vyhledávání: '"Linda Labberton"'
Autor:
Linda Labberton, Ellinor Kenne, Andy T. Long, Katrin F. Nickel, Antonio Di Gennaro, Rachel A. Rigg, James S. Hernandez, Lynn Butler, Coen Maas, Evi X. Stavrou, Thomas Renné
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The inorganic procoagulant polymer polyphosphate participates in thrombosis via factor XII. Here the authors use recombinant probes that specifically bind or degrade circulating polyphosphate to protect mice in arterial and venous thrombosis models w
Externí odkaz:
https://doaj.org/article/f48adfdce9824e40bf17559630815825
Autor:
Christine L.H. Snozek, Katrin F. Nickel, Evi X. Stavrou, James S Hernandez, Thomas Renné, Linda Labberton, Sandra J. Gendler, Coen Maas, Andy T. Long, Stefan Blankenberg
Publikováno v:
Cytometry Part B: Clinical Cytometry. 94:369-373
Background Platelet polyphosphate is an inorganic procoagulant polymer of orthophosphate units that is stored in dense granules and is released upon platelet activation. Here, we describe an assay to measure polyphosphate on the surface of procoagula
Autor:
Andy T. Long, Florian Langer, Tobias A. Fuchs, Evi X. Stavrou, Thomas Renné, Katrin F. Nickel, Linda Labberton, Lynn M. Butler
Publikováno v:
Thrombosis Research. 141:S4-S7
Cancer is an established risk factor for venous thromboembolism (VTE) and VTE is the second leading cause of death in patients with cancer. The incidence of cancer-related thrombosis is rising and is associated with worse outcomes. Despite our growin
Publikováno v:
Hämostaseologie. 35:338-350
SummaryBlood coagulation is essential for hemostasis, however excessive coagulation can lead to thrombosis. Factor XII starts the intrinsic coagulation pathway and contact-induced factor XII activation provides the mechanistic basis for the diagnosti
Autor:
Rachel A. Rigg, Lynn M. Butler, Linda Labberton, Evi X. Stavrou, Thomas Renné, James S Hernandez, Andy T. Long, Coen Maas, Katrin F. Nickel, Ellinor Kenne, Antonio Di Gennaro
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications [E], 7. Nature Publishing Group
Nature Communications
Nature Communications [E], 7. Nature Publishing Group
Polyphosphate is an inorganic procoagulant polymer. Here we develop specific inhibitors of polyphosphate and show that this strategy confers thromboprotection in a factor XII-dependent manner. Recombinant Escherichia coli exopolyphosphatase (PPX) spe
Autor:
Linda, Labberton, Andy T, Long, Sandra J, Gendler, Christine L, Snozek, Evi X, Stavrou, Katrin F, Nickel, Coen, Maas, Stefan, Blankenberg, James S, Hernandez, Thomas, Renné
Publikováno v:
Cytometry. Part B, Clinical cytometry. 94(2)
Platelet polyphosphate is an inorganic procoagulant polymer of orthophosphate units that is stored in dense granules and is released upon platelet activation. Here, we describe an assay to measure polyphosphate on the surface of procoagulant human pl
Autor:
Evi X. Stavrou, Thomas Renné, Tobias A. Fuchs, Markus Graefen, Gunnar Ronquist, Göran Ronquist, Nigel Mackman, Florian Langer, Carsten Bokemeyer, Guido Sauter, Katrin F. Nickel, Linda Labberton
Publikováno v:
Blood. 126(11)
Cancer is a leading cause of thrombosis. We identify a new procoagulant mechanism that contributes to thromboembolism in prostate cancer and allows for safe anticoagulation therapy development. Prostate cancer-mediated procoagulant activity was reduc
Autor:
Raymond M. Schiffelers, Johan J F Verhoef, Steven de Maat, Ellinor Kenne, Thomas Renné, Coen Maas, Kim Dijkxhoorn, Owen J. T. McCarty, Marcel H.A.M. Fens, Arjan D. Barendrecht, Harry F. G. Heijnen, Antoni P. A. Hendrickx, Katrin F. Nickel, Linda Labberton, Huub Schellekens
Publikováno v:
Blood, 129(12), 1707. American Society of Hematology
Polyphosphate is an inorganic polymer that can potentiate several interactions in the blood coagulation system. Blood platelets contain polyphosphate, and the secretion of platelet-derived polyphosphate has been associated with increased thrombus for
Autor:
Antonio Di Gennaro, Ulrich Hassiepen, Katrin F. Nickel, Tobias A. Fuchs, Olga Luengo, Andy T. Long, Evi X. Stavrou, Thomas Renné, Thorsten Krieger, Ellinor Kenne, Hartmut Schlüter, Keith R. McCrae, Stefanie Flohr, Riccardo Senter, Mar Guilarte, Moisés Labrador, Jenny Björkqvist, Lynn M. Butler, Anne Jämsä, Frederic Cumin, Anna Sala-Cunill, Victoria Cardona, Linda Labberton, Parvin Kumar, Coen Maas
Publikováno v:
Journal of Allergy and Clinical Immunology, 135(4), 1031. Mosby Inc.
BASE-Bielefeld Academic Search Engine
Europe PubMed Central
BASE-Bielefeld Academic Search Engine
Europe PubMed Central
Background Anaphylaxis is an acute, potentially lethal, multisystem syndrome resulting from the sudden release of mast cell–derived mediators into the circulation. Objectives and Methods We report here that a plasma protease cascade, the factor XII
Publikováno v:
ResearcherID
Intestinal pathogens such as Entamoeba spp. and Giardia spp. protozoans are not uncommon among rhesus macaques (Macaca mulatta) in research facilities. These infections affect the health of the macaques, potentially causing severe diarrhea, and also