Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Linda L. Setescak"'
2
[(3-Aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series
Autor: J. C. Wilker, Richard C. Effland, Richard C. Allen, Linda L. Setescak, Karen Ranbom, Larry Davis, William J. Novick, Jan M. Kitzen, Gregory M. Shutske
Publikováno v: Journal of Medicinal Chemistry. 25:36-44
A series of [(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids was synthesized and tested for diuretic activity in saline-loaded mice and in conscious, water-loaded dogs. The structural requirements for good diuretic activity in both mice and dogs were
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e6d5cbc655d5e268f413b26d07f300
https://doi.org/10.1021/jm00343a008
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3
Synthesis of novel 1,2,3,4-tetrahydrobenzo[c]-1,5-naphthyridines from pyrrolo[1,2-b]isoquinolines
Autor: Donna Van Engen, Lawrence L. Martin, Scott Susan J, Linda L. Setescak
Publikováno v: Journal of Heterocyclic Chemistry. 24:1541-1549
1,2,3,4-Tetrahydrobenzo[c]-1,5-naphthyridine (5a) was prepared by a novel synthetic route involving the rearrangement of (±)-(Z)-1,10a-dihydropyrrolo[1,2-b]isoquinoline-3,10(2H,5H)-dione oxime to afford 1,4-dihydrobenzo[c]-1,5-naphthyridin-2(3H)-one
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3491f83bda46b072fad2d95075ec0cea
https://doi.org/10.1002/jhet.5570240609
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4
(.+-.)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 3. 2-Phenyl and 2-amino analogs as potential antihypertensive agents
Autor: Frederick W. Dekow, Lawrence L. Martin, Linda L. Setescak, Jan M. Kitzen
Publikováno v: Journal of Medicinal Chemistry. 27:401-404
A series of 2-phenyl- and 2-amino-4-aryl-4,5-dihydro-3H-1,3-benzodiazepines was prepared and submitted for broad biological screening, including evaluation for potential antihypertensive activity. Compound 4a [(+/-)-4,5-dihydro-2,4-diphenyl-3-methyl-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dedb3c8018800c1bcbb60b676c02931
https://doi.org/10.1021/jm00369a029
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6
Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 4. Synthesis and evaluation of 4-(4,10-dihydro-10-oxothieno[3,2-c] [1]benzoxepin-8-yl)butanol and -butyric acid and related derivatives
Autor: Helsley Grover C, Lawrence L. Martin, T. C. Spaulding, Linda L. Setescak
Publikováno v: Journal of medicinal chemistry. 27(3)
4,10-Dihydro-10-oxothieno[3,2-c][1]benzoxepin-8-acetic acid (6) was previously reported as a potent antiinflammatory-analgesic agent characterized by an impressive therapeutic ratio in comparison with indomethacin. With the goal of finding compounds
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022799d1e493713fda59669aab492c7a
https://pubmed.ncbi.nlm.nih.gov/6607999
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8
(+/-)-4-Aryl-4,5-dihydro-3H-1,3-benzodiazepines. 2. Nuclear-substituted analogues of (+/-)-4,5-dihydro-2,3-dimethyl-4-phenyl-3H-1,3-benzodiazepine and (+/-)-4,5-dihydro-2-ethyl-3-methyl-4-phenyl-3H-1,3-benzodiazepine as potential antidepressant agents
Autor: Lawrence L. Martin, Charles A. Crichlow, Linda L. Setescak, J. C. Wilker, Manfred Worm, H M Geyer rd
Publikováno v: Journal of medicinal chemistry. 25(4)
Antidepressant-like activity, as evidenced by marked inhibition of tetrabenazine-induced ptosis, was previously reported for (+/-)-4,5-dihydro-4-phenyl-3H-1,3-benzodiazepine derivatives. Since optimal antitetrabenazine activity was associated with (+
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67891b384ce0844dbe2b1e8be3c673a8
https://pubmed.ncbi.nlm.nih.gov/7069712
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