Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Linda L. Coughenour"'
1
1-Aminoindanes as novel motif with potential atypical antipsychotic properties
Autor: Linda L. Coughenour, Bridget M. Barr, Sham S. Nikam, David L. Rock, James Michael Graham
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:489-493
As part of an on-going effort to investigate the chemical space requirements for D(2)/5-HT(2A) receptor antagonists as atypical antipsychotics, new 1-aminoindanes were synthesized. The replacement of the heterocycle (oxindole) in ziprasidone with a c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c49d0cefb5e90a818f338bf9527c1a1
https://doi.org/10.1016/j.bmcl.2007.11.106
Zobrazit plný text záznamu
2
8-Substituted 3,4-dihydroquinolinones as a novel scaffold for atypical antipsychotic activity
Autor: Linda L. Coughenour, Jamie Singer, Walters Michael, Tracy Fay Gregory, Bridget M. Barr
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:4560-4563
Several new, potent dopamine subtype 2 (DA D2) active compounds with serotonin subtype 2A (5-HT2A) pharmacology are presented. 8-Substituted 3,4-dihydroquinolinones, tetrahydroquinolines, and N-acyl tetrahydroquinolines were evaluated in primary assa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4c179a3db18ce9f9148dd8c518318a
https://doi.org/10.1016/j.bmcl.2005.06.097
Zobrazit plný text záznamu
3
4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: A Novel, Potent, and Selective NR1/2B NMDA Receptor Antagonist
Autor: Edward R. Whittemore, Minhtam Tran, David Rock, Richard M. Woodward, Zhang-Lin Zhou, Sui Xiong Cai, Christopher S. Konkoy, Stephen A. Espitia, Lawrence D. Wise, Christopher F. Bigge, John F. W. Keana, Jon E. Hawkinson, Eckard Weber, Peter A. Boxer, Linda L. Coughenour
Publikováno v: Journal of Medicinal Chemistry. 42:2993-3000
A structure-based search and screen of our compound library identified N-(2-phenoxyethyl)-4-benzylpiperidine (8) as a novel N-methyl-D-aspartate (NMDA) receptor antagonist that has high selectivity for the NR1/2B subunit combination (IC(50) = 0.63 mi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f0076ffe71bb601601d1cf2ac46fcd
https://doi.org/10.1021/jm990246i
Zobrazit plný text záznamu
4
A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death
Autor: Albert W. Probert, Peter A. Boxer, SA Borosky, Kevin K.W. Wang, Linda L. Coughenour, Iradj Hajimohammadreza, Frank W. Marcoux
Publikováno v: The Journal of Neuroscience. 15:4093-4101
Calcium/calmodulin-dependent protein kinase-II (CamK-II) is a major neuronal protein which plays a significant role in the cellular process of long-term potentiation (LTP), and vesicular release of neurotransmitters. Here, we show that KN-62, 1-[N,O-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e06f3297048e6b5ef7b9987ba74a7eb
https://doi.org/10.1523/jneurosci.15-05-04093.1995
Zobrazit plný text záznamu
8
Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5
Autor: Susan Fisher, Anthony Jerome Thomas, Sharie L. Myers, Michael R. Pavia, Walter H. Moos, Kathryn B. Sanders, Robert E. Davis, Linda L. Coughenour
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:803-808
There is considerable interest in muscarinic acetylcholine receptor (mAChR) subtype selective agents as cholinomimetics for the treatment of senile dementia of the Alzheimer's type (SDAT). A series of substituted analogs similar to the muscarinic ago
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0756b300258b502df83d79675763c24d
https://doi.org/10.1016/s0960-894x(00)80535-1
Zobrazit plný text záznamu
9
Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced .alpha.-amino acids as competitive N-methyl-D-aspartic acid antagonists
Autor: Laura J. Brahce, Daniel F. Ortwine, Christopher F. Bigge, Daniel Martin Retz, Linda L. Coughenour, Frank W. Marcoux, Graham Johnson, Albert W. Probert, James T. Drummond
Publikováno v: Journal of Medicinal Chemistry. 35:1371-1384
A series of N-substituted alpha-amino acids containing terminal phosphonic acid groups has been synthesized as potential N-methyl-D-aspartate (NMDA) receptor antagonists. NMDA receptor affinity was determined by displacement of a known ligand ([3H]CP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7c927f723ddcc8ca7e03127ecbe94d
https://doi.org/10.1021/jm00086a005
Zobrazit plný text záznamu
10
Excitatory amino acids: 6-phosphonomethyltetrahydro-4-pyrimidinecarboxylic acids and their acyclic analogues are competitive N-methyl-D-aspartic acid receptor antagonists
Autor: Linda L. Coughenour, Christopher F. Bigge, Cynthia M. Hanchin, James T. Drummond, Jiang-Ping Wu
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 2:207-212
6-Phosphonoalkyltetrahydro-4-pyrimidinecarboxylic acids and their acyclic equivalents were determined to be competitive N-methyl-D-aspartic acid (NMDA) receptor antagonists using a [3H]-CPP binding assay. Results suggest that internal hydrogen bondin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7a0d302c38f2e631aa5be9e81476561
https://doi.org/10.1016/s0960-894x(01)81066-0
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje