A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity

Autor: Marnie Higgins-Garn, M. Ann Mongan, Toni Williamson, Charles W. Qualls, Cynthia A. Afshari, Suzanne C. Moss, Steven Vonderfecht, Robert T. Dunn, Nancy E. Everds, Jeanine L. Bussiere, Yuan Chen, Yudong D. He, Guang Chen, Linda L. Carlock, Cheng Su, Hisham K. Hamadeh, Christopher R DiPalma

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 12, p e15595 (2010)

Genome-wide gene expression profiling has become standard for assessing potential liabilities as well as for elucidating mechanisms of toxicity of drug candidates under development. Analysis of microarray data is often challenging due to the lack of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac0aecc1e95fbad2b531929e7075ca2
https://pubmed.ncbi.nlm.nih.gov/21203578

Contributors

Autor: Husein Ajwa, Iris S. Ale, Sandra L. Allen, Judith Alsop, Gail Arce, D.J. Ashworth, Sharada Balakrishnan, John B. Barnett, Dana B. Barr, Terrell Barry, Ronald E. Baynes, Sheryl Beauvais, Karin S. Bentley, Craig E. Bernard, Nida Besbelli, Richard Billington, Ann M. Blacker, Jerry N. Blancazo, Charles B. Breckenridge, Gerald T. Brooks, James Bruckner, Kathleen M. Brundage, Quang Bui, Franca M. Buratti, James S. Bus, Geoffrey M. Calvert, Linda L. Carlock, John E. Casida, Howard W. Chambers, Janice E. Chambers, Heidi P. Chan, Graham Chester, J. Marshall Clark, Thomas Class, M. Scott Clifton, Roger Cochran, Emma Di Consiglio, Curtis C. Dary, Franck E. Dayan, Allison L. De Vries, Kelly J. Dix, Michael H. Dong, Timothy A. Dotson, John Doull, Jeffrey H. Driver, Stephen O. Duke, M. Bigelow Dyk, David A. Eastmond, David L. Eaton, Marion Ehrich, David L. Eisenbrandt, J. Charles Eldridge, Jeffrey B. Evans, Donna Farmer, Allan S. Felsot, Penelope A. Fenner-Crisp, Joan L. Fletcher, Sara Flores, Roy Fortmann, Toshio Fujita, Derek W. Gammon, Suduan Gao, V.F. Garry, Sean C. Gehen, Panos Georgopoulos, B.B. Gollapudi, Elliot B. Gordon, F. Guerino, Thomas R. Hanley, Lindsay Hanson, Paul R. Harp, Michael C. Harrass, Jane E. Harris, Wayland J. Hayes, Thomas Hertner, Frederick G. Hess, William F. Heydens, Ernest Hodgson, L. Holden, Jon A. Hotchkiss, Susan Hurt, Sastry Isukapalli, Seshadri Iyengar, Poorni Iyer, Inge M. Jensen, Russell L. Jones, Bernard S. Jortner, Hideo Kaneko, Robert J. Kavlock, Iain D. Kelly, Michael P. Kenna, Elke Kennepohl, Young Soo Keum, Jeong-Han Kim, Loreen Kleinschmidt, Dennis R. Klonne, James B. Knaak, Mike E. Krolski, Ian C. Lamb, Richard L. Lampman, Mikael Langner, Jennifer L. Lantz, Dominique Lasserre-Bigot, Edward D. Levin, Qing X. Li, Jing Liu, Edward A Lock, Marcello Lotti, Curt Lunchick, A.V. Lyubimov, Howard Maibach, Lisa E. Maier, Susan Makris, Mark J. Manning, Rex E. Marsh, Melanie Marty, Ursula May-Hertl, Thomas McCurdy, Tom McKone, Edward C. Meek, Louise N. Mehler, Gary J. Mihlan, Thomas B. Moore, Marsha K. Morgan, Ian C. Munro, Toshio Narahashi, Keiichiro Nishimura, Robert J. Novak, William J. Ntow, Michael A. O’Malley, Frederick W. Oehme, Janet Ollinger, Thomas G. Osimitz, Muhilan D. Pandian, P.P. Parsons, Merle G. Paule, Virginie Payraudeau, Erin C. Peck, Alain F. Pelfrène, Kimberly Pendino, Barbara J. Petersen, Amanda L. Piccirillo, Vincent J. Piccirillo, Joachim D. Pleil, Kathryn Ponnock, Carey Pope, Robert H. Poppenga, Su-wei Qi, Ruijun Qin, Deborah Ramsingh, Lawrence W. Reiter, Rudy J. Richardson, Leonard Ritter, Jim E. Riviere, John H. Ross, Karl K. Rozman, Andrew L. Rubin, Michael K. Rust, Luis O. Ruzo, Terrell P. Salmon, G.K. (Ghona) Sangha, James N. Seiber, Frank Selman, Larry P. Sheets, Linda S. Sheldon, Marilyn Silva, James W. Simpkins, William Slikker, Paul Slovic, Andrew G. Smith, Wayne R. Snodgrass, Jon R. Sobus, David M. Soderlund, Keith R. Solomon, Frank Spurlock, James T. Stevens, Tammy E. Stoker, W.T. Stott, Daniel L. Sudakin, Chiyozo Takayama, Emanuela Testai, Thomas Thongsinthusak, Charles Timchalk, Olga A. Timofeeva, Abraham J. Tobia, Rogelio Tornero-Velez, Nicolle S. Tulve, Matazaemon Uchida, István Ujváry, Daniel Vallero, Bennard van Ravenswaay, Felix Waechter, Edgar Weber, Ronald C. Wester, Paul Whatling, Gary K. Whitmyre, Heinrich Wicke, Sanjeeva J. Wijeyesakere, Martin F. Wilks, Alan G.E. Wilson, Barry W. Wilson, Michael D. Woodward, Jayne Wright, S.R. Yates, Masanori Yoshida, Bruce M. Young, Frank G. Zalom, Valerie Zartarian, Hongbo Zhai, Xiaofei Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a870b5ec229c808850c63447b71171b2
https://doi.org/10.1016/b978-0-12-374367-1.00124-5

Contributors to the Handbook

Autor: Gail Acre, John L. Adgate, Bruce N. Ames, Sharada Balakrishman, Margot Barnett, Ronald E. Baynes, Richard Billington, Jerome M. Blondell, J. Scott Boone, Ruaidhri Breathnach, Charles B. Breckenridge, Gerald T. Brooks, Derk H. Brouwer, Quang Bui, Geoffrey M. Calvert, Linda L. Carlock, Neal Carmichael, Russell L. Carr, Howard W. Chambers, Janice E. Chambers, Graham Chester, J. Marshall Clark, Thomas Clarkson, Thomas Class, Roger C. Cochran, Franck E. Dayan, Johan S. de Cock, Kelly J. Dix, Michael Dong, Timothy A. Dotson, John Doull, Jeffrey H. Driver, Stephen O. Duke, David A. Eastmond, Donald J. Ecobichon, Marion Ehrich, David L. Eisenbrandt, J. Charles Eldridge, Jeffrey B. Evans, Donna Farmer, Pennelope A. Fenner- Crisp, Toshio Fujita, Derek W. Gammon, V.F. Garry, Paul Glynn, B.B. Gollapudi, Gay Goodman, Elliot B. Gordon, Thomas R. Hanley, Paul Harp, Jane E. Harris, Wayland J. Hayes, Leon W. Hershberger, Thomas Hertner, Frederick G. Hess, William F. Heydens, Ernest Hodgson, Robert M. Hollingworth, Susan Hurt, Poorni R. Iyer, Richard J. Jackson, Martin K. Johnson, Bernard S. Jortner, Hideo Kaneko, Robert J. Kavlock, Michael P. Kenna, Elke Kennepohl, William C. Krieger, Ian C. Lamb, Richard L. Lampman, Patricia E. Levi, A.V. Lyubimov, Jing Liu, Edward A. Lock, Marcello Lotti, Curt Lunchik, Howard I. Maibach, Neela B. Manley, Shajan Mannala, Rex E. Marsh, Peter McCahon, Michael McGeehin, Louise N. Mehler, Junshi Miyamoto, Thomas B. Moore, Ronald L. Mull, Ian C. Munro, Toshio Narahashi, Keiichiro Nishimura, Kenneth D. Nitschke, Robert J. Novak, Michael O'Malley, Frederick W. Oehme, Janet Ollinger, Thomas G. Osimitz, Muhilan D. Pandian, P.P. Parsons, Alain F. Pelfrene, Kimberly Pendino, Barbara J. Petersen, Keith F. Pfeifer, Vincent J. Piccirillo, Jack R. Plimmer, Kathryn Ponnock, Pierre-Gerard Pontal, Carey Pope, David E. Ray, Joseph P. Rieth, Jim E. Riviere, Kathleen E. Rodgers, Joanne G. Romagni, John H. Ross, Karl K. Rozman, Carol H. Rubin, Andrew L. Rubin, Michael K. Rust, Luis O. Ruzo, Wayne T. Sanderson, Kai Savolainen, Gerald P. Schoenig, James N. Seiber, Ken Sexton, Larry P. Sheets, James Simpkins, Thomas H. Slone, Paul Slovic, Andrew G. Smith, Wayne R. Snodgrass, Keith R. Solomon, James T. Stevens, W.T. Stott, Phillip L. Strong, Lois Swirsky Gold, Chiyozo Takayama, Charles A. Timchalk, Abraham J. Tobia, Matazaemon Uchida, István Ujváry, Joop J. van Hemmen, Bennard van Ravenswaay, Felix Waechter, Cassi L. Walls, Edgar Weber, Ronald C. Wester, Gary K. Whitmyre, Martin F. Wilks, Rick Williams, Barry W. Wilson, Alan G.E. Wilson, Masanori Yoshida, Susan H. Youngren, Frank G. Zalom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8ea66a886864fe9df480c8f47540047
https://doi.org/10.1016/b978-012426260-7.50001-x

TOXICITY, SURVIVABILITY, AND ACTIVITY PATTERNS OF NORTHERN BOBWHITE QUAIL DOSED WITH THE INSECTICIDE TERBUFOS—Short Communication

Autor: George P. Cobb, Ronald J. Kendall, Larry W. Brewer, Rone A. Brewer, Linda L. Carlock, Michael J. Hooper

Publikováno v: Environmental Toxicology and Chemistry. 15:750

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2477dc0bfa23086035e012f9e2a48a5b
https://doi.org/10.1897/1551-5028(1996)015<0750:sctsaa>2.3.co

A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity.

Autor: Mongan MA; Comparative Biology and Safety Sciences, Amgen Inc, Thousand Oaks, California, United States of America. thuyv@amgen.com, Dunn RT, Vonderfecht S, Everds N, Chen G, Su C, Higgins-Garn M, Chen Y, Afshari CA, Williamson TL, Carlock L, Dipalma C, Moss S, Bussiere J, Qualls C, He YD, Hamadeh HK

Publikováno v: PloS one [PLoS One] 2010 Dec 21; Vol. 5 (12), pp. e15595. Date of Electronic Publication: 2010 Dec 21.