Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Linda L Hardy"'
Autor:
Jewel Banik, Ana Rita Silva Moreira, Juchan Lim, Sophia Tomlinson, Linda L. Hardy, Alex Lagasse, Anessa Haney, Meghan R. Crimmins, Ulrich Boehm, Angela K. Odle, Melanie C. MacNicol, Gwen V. Childs, Angus M. MacNicol
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The pituitary functions as a master endocrine gland that secretes hormones critical for regulation of a wide variety of physiological processes including reproduction, growth, metabolism and stress responses. The distinct hormone-producing c
Externí odkaz:
https://doaj.org/article/367dcc30f1c442de93a8c3febc716b13
Autor:
Charlotte E Rutledge, Ho-Tak Lau, Hazel Mangan, Linda L Hardy, Olaf Sunnotel, Fan Guo, Angus M MacNicol, Colum P Walsh, Diane J Lees-Murdock
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88385 (2014)
Regulation of DNMT1 is critical for epigenetic control of many genes and for genome stability. Using phylogenetic analysis we characterized a block of 27 nucleotides in the 3'UTR of Dnmt1 mRNA identical between humans and Xenopus and investigated the
Externí odkaz:
https://doaj.org/article/ded1e919582a401c89d9eaa7a96e6861
Autor:
Jewel Banik, Gwen V Childs, Linda L Hardy, Juchan Lim, Angus M MacNicol, Melanie C MacNicol, Sophia Tomlinson, Alicja Urbaniak
Publikováno v:
Journal of the Endocrine Society. 6:A578-A578
The pituitary gland controls responses to changing physiological requirements during growth, pregnancy, puberty, and stress. Synthesis and secretion of appropriate pituitary hormones in response to changing organismal demands is mediated through a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa28424451c925b5d929a0680d102971
https://doi.org/10.1210/jendso/bvac150.1199
https://doi.org/10.1210/jendso/bvac150.1199
Autor:
Alan J. Tackett, Melanie C. MacNicol, Gwen V. Childs, Nicola K. Gray, Chad E. Cragle, Stephanie D. Byrum, Samuel G. Mackintosh, Angus M. MacNicol, Linda L. Hardy, William A. Richardson
Publikováno v:
J Biol Chem
Cragle, C E, MacNicol, M C, Byrum, S D, Hardy, L L, Mackintosh, S G, Richardson, W A, Gray, N K, Childs, G V, Tackett, A J & MacNicol, A M 2019, ' Musashi interaction with poly(A) binding protein is required for activation of target mRNA translation ', Journal of Biological Chemistry, vol. 294, no. 28, pp. 10969-10986 . https://doi.org/10.1074/jbc.RA119.007220
Cragle, C E, MacNicol, M C, Byrum, S D, Hardy, L L, Mackintosh, S G, Richardson, W A, Gray, N K, Childs, G V, Tackett, A J & MacNicol, A M 2019, ' Musashi interaction with poly(A) binding protein is required for activation of target mRNA translation ', Journal of Biological Chemistry, vol. 294, no. 28, pp. 10969-10986 . https://doi.org/10.1074/jbc.RA119.007220
The Musashi family of mRNA translational regulators control both physiological and pathological stem cell self-renewal primarily by repressing target mRNAs that promote differentiation. In response to differentiation cues, Musashi can switch from a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b799626c93916368b9414463f0120599
https://doi.org/10.1074/jbc.ra119.007220
https://doi.org/10.1074/jbc.ra119.007220
Autor:
Melanie C. MacNicol, Anessa Haney, Tiffany K. Miles, Angus M. MacNicol, Melody Allensworth-James, Linda L. Hardy, Alex N. LaGasse, Gwen V. Childs, Angela K. Odle, Juchan Lim
Publikováno v:
J Neuroendocrinol
In normal individuals, pituitary somatotrophs optimise body composition by responding to metabolic signals from leptin. To identify mechanisms behind the regulation of somatotrophs by leptin, we used Cre-LoxP technology to delete leptin receptors (LE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63117749a8e2452c532b1fc7f49950cb
https://europepmc.org/articles/PMC8086172/
https://europepmc.org/articles/PMC8086172/
Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi
Autor:
Linda L. Hardy, Nathan L. Avaritt, Christopher J. Lengner, Melanie C. MacNicol, Christian L Thomas, Michael G. Kharas, Angus M. MacNicol, Gwen V. Childs, Jordan T. Bird, Melody Allensworth-James, Stephanie D. Byrum, Angela K. Odle, Jewel Banik, Alex N. LaGasse, Ana Rita Silva Moreira
Publikováno v:
Endocrinology
The adipokine leptin regulates energy homeostasis through ubiquitously expressed leptin receptors. Leptin has a number of major signaling targets in the brain, including cells of the anterior pituitary (AP). We have previously reported that mice lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba73adafda175a3669a26b5e2130c567
https://pubmed.ncbi.nlm.nih.gov/33373440
https://pubmed.ncbi.nlm.nih.gov/33373440
Autor:
Melanie C. MacNicol, Stephanie Byrum, Linda L. Hardy, Gwen V. Childs, Nathan Avaritt, Angus M. MacNicol, Juchan Lim, Angela K. Odle, Ana Rita Silva Moreira, Melody Allensworth, Jewel Banik, Alex N. LaGasse, Anessa Haney
Publikováno v:
Journal of the Endocrine Society
The activation of transcription factor Pou1f1 at embryonic day 13 gives rise to the pituitary populations of somatotropes, lactotropes, and thyrotropes and these populations maintain expression of Pou1f1 throughout life. The Musashi family of RNA reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207d52aa422f2dd5d25f4f98149c4593
https://doi.org/10.1210/jendso/bvaa046.1909
https://doi.org/10.1210/jendso/bvaa046.1909
Autor:
Gwen V. Childs, Juchan Lim, Linda L. Hardy, Alex N. LaGasse, Tiffany K Miles, Melanie C. MacNicol, Melody Allensworth-James, Angus MacNicol, Anessa Haney, Angela K. Odle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4cc04f3c85be3137376fb4c99673553
https://doi.org/10.1111/jne.12883/v2/response1
https://doi.org/10.1111/jne.12883/v2/response1
Autor:
Yan-Dong Wang, F. Kennedy McDaniel, Karthik Arumugam, Melanie C. MacNicol, Ania Wilczynska, Daohong Zhou, Yasir Rahmatallah, Gwen V. Childs, Angus M. MacNicol, Galina V. Glazko, Chad E. Cragle, Linda L. Hardy
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Scientific Reports
Scientific Reports
The Musashi family of RNA binding proteins act to promote stem cell self-renewal and oppose cell differentiation predominantly through translational repression of mRNAs encoding pro-differentiation factors and inhibitors of cell cycle progression. Du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d355f5e90c31f9284928ea71f9bbf6be
http://link.springer.com/article/10.1038/s41598-017-11917-3
http://link.springer.com/article/10.1038/s41598-017-11917-3
Autor:
Anessa Haney, Tiffany K. Miles, Ana Rita Silva Moreira, Christopher J. Lengner, Gwen V. Childs, Linda L. Hardy, Melody Allensworth, Michael G. Kharas, Angus M. MacNicol, Melanie C. MacNicol, Angela K. Odle
Publikováno v:
Journal of the Endocrine Society
Leptin is a critical mediator of metabolic regulation of the hypothalamic-pituitary gonadal (HPG) axis. We have previously shown that leptin is responsible for the optimal expression of GnRHR, a rate-limiting component of the reproductive process. Fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc2915f97e11951034ce5bc0ff1f9ea
http://europepmc.org/articles/PMC6552265
http://europepmc.org/articles/PMC6552265