Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Linda Kotilinek"'
Autor:
Xiaohui Zhao, James P. Cleary, Martin Ramsden, Chris Hlynialuk, Benjamin Smith, Kathleen R. Zahs, Karen H. Ashe, Linda Kotilinek
Publikováno v:
Nature Medicine. 22:1268-1276
In Alzheimer's disease (AD) and other tauopathies, the tau protein forms fibrils, which are believed to be neurotoxic. However, fibrillar tau has been dissociated from neuron death and network dysfunction, suggesting the involvement of nonfibrillar s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35db7774bb04f3370afe4a9b9a62ff96
https://doi.org/10.1038/nm.4199
https://doi.org/10.1038/nm.4199
Autor:
Peng Liu, Linda Kotilinek, Colleen L. Forster, Wei Qiang, John H. Reichl, Joanna L. Jankowsky, Angie C.A. Chiang, James P. Cleary, Miranda N. Reed, Karen H. Ashe, Carrie M. Wilmot, Samantha L. Shapiro, Kathleen R. Zahs, Marianne K. O. Grant
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1760-1771 (2015)
SummaryThe accumulation of amyloid-β (Aβ) as amyloid fibrils and toxic oligomers is an important step in the development of Alzheimer’s disease (AD). However, there are numerous potentially toxic oligomers and little is known about their neurolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e263dde3ba6c55ae521da9e3c99accdf
http://www.sciencedirect.com/science/article/pii/S2211124715005471
http://www.sciencedirect.com/science/article/pii/S2211124715005471
Autor:
Marianne K. O. Grant, Rose Pitstick, Linda Kotilinek, George A. Carlson, Dezhi Liao, Rachel D. Penrod, Lorene M. Lanier, Karen H. Ashe, Jianjun Su, Brian R. Hoover, Li-Lian Yuan, Miranda N. Reed
Publikováno v:
Neuron. 68(6):1067-1081
SummaryThe microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8728e69c502921f10e12dd8ce8960ba8
Publikováno v:
Behavioural Brain Research. 212:115-120
The most widely used mouse model of Alzheimer's disease is the Tg2576 (APP(SWE)) model. While general agreement about their neuropathology prevails, disparate results concerning cognitive changes have been reported. To resolve this controversy, we co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ac6af934307c095a5f188197c3782d
https://doi.org/10.1016/j.bbr.2010.03.037
https://doi.org/10.1016/j.bbr.2010.03.037
Autor:
James P. Cleary, Roger Anwyl, Linda H. Younkin, Linda Kotilinek, Roi Ann Wallis, Sally A. Frautschy, Michael J. Rowan, Karen H. Ashe, Agnieszka M. Falinska, Steven G. Younkin, Sylvain Lesné, Grace Y. Sun, Giselle P. Lim, Qinwen Wang, Greg M. Cole, Marcus A. Westerman, Agnes Simonyi, Kimberly L. Panizzon
Publikováno v:
Brain. 131:651-664
Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia characterized by the accumulation of amyloid plaques containing the amyloid-beta protein (Abeta).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4c04ce7e85b3189978d33ca3aaac70
https://doi.org/10.1093/brain/awn008
https://doi.org/10.1093/brain/awn008
Publikováno v:
Neuroscience. 151:745-749
The amyloid-beta (Abeta) protein exists in the aging mammalian brain in diverse assembly states, including amyloid plaques and soluble Abeta oligomers. Both forms of Abeta have been shown to impair neuronal function, but their precise roles in Alzhei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ee9bc35e573ad38d91555cd069fb62
https://doi.org/10.1016/j.neuroscience.2007.10.054
https://doi.org/10.1016/j.neuroscience.2007.10.054
Autor:
Linda Kotilinek, Karen H. Ashe, Huifang Ma, Linda H. Younkin, Colleen L. Forster, Jill Steidl-Nichols, Martin Citron, Steven G. Younkin, Nicolas Sergeant, Mathew A. Sherman, André Delacourte, Robert Vassar, Sylvain Lesné, Paulo Kofuji, Linda M. Boland
Publikováno v:
Proceedings of the National Academy of Sciences. 104:8167-8172
The amyloid precursor protein (APP) undergoes sequential cleavages to generate various polypeptides, including the amyloid-β protein (Aβ), which forms amyloid plaques in Alzheimer's disease (AD), secreted APPα (sAPPα) which enhances memory, and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a17cb18c70dcc96343f552eda94edf2
https://doi.org/10.1073/pnas.0609521104
https://doi.org/10.1073/pnas.0609521104
Autor:
Elizabeth B. Engler-Chiurazzi, Karen H. Ashe, Daniel S. Weitzner, Miranda N. Reed, Linda Kotilinek
Publikováno v:
Journal of Visualized Experiments.
The Morris water maze (MWM) is a commonly used task to assess hippocampal-dependent spatial learning and memory in transgenic mouse models of disease, including neurocognitive disorders such as Alzheimer’s disease. However, the background strain of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ce2fbb27b901f92588329dd83c35a5
https://doi.org/10.3791/52706
https://doi.org/10.3791/52706
Autor:
Ming Teng Koh, Karen H. Ashe, Linda Kotilinek, Charles G. Glabe, Michela Gallagher, Austin J. Yang, Rakez Kayed, Sylvain Lesné
Publikováno v:
Nature. 440:352-357
Memory function often declines with age, and is believed to deteriorate initially because of changes in synaptic function rather than loss of neurons. Some individuals then go on to develop Alzheimer's disease with neurodegeneration. Here we use Tg25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd1771c1d7c8add7616182466e3546a
https://doi.org/10.1038/nature04533
https://doi.org/10.1038/nature04533
Autor:
George A. Carlson, Steven G. Younkin, Linda H. Younkin, Marcus A. Westerman, Ami Mariash, Linda Kotilinek, Takeshi Kawarabayashi, Karen H. Ashe, Deirdre Cooper-Blacketer
Publikováno v:
The Journal of Neuroscience. 22:1858-1867
Transgenic mice expressing mutant amyloid precursor proteins (APPs) have provided important new information about the pathogenesis of Alzheimer's disease (AD) histopathology. However, the molecular basis of memory loss in these mice is poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d5d9f73fb1e3021db7a73a24db7378
https://doi.org/10.1523/jneurosci.22-05-01858.2002
https://doi.org/10.1523/jneurosci.22-05-01858.2002