Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Linda K. Gorman"'
Publikováno v:
Behavioral neuroscience. 127(5)
Male Long-Evans rats were given injections of either 192 IgG-saporin, an apparently selective toxin for basal forebrain cholinergic neurons (LES), or vehicle (CON) into either the medial septum and vertical limb of the diagonal band (MS/VDB) or bilat
Publikováno v:
Behavioural Brain Research. 80:99-109
Age-related spatial memory deficits are correlated with septohippocampal cholinergic system degeneration. The present study examined the effect of intraseptal infusions of the cholinergic agonist, oxotremorine, on spatial reference memory in middle-a
Publikováno v:
Brain Research. 694:177-182
Nitric oxide (NO) is a candidate retrograde messenger involved in synaptic plasticity, and is linked to the cholinergic system in the brain. We examined the role of NO in the acquisition of visual and spatial discriminations by daily administration o
Autor:
Russell T. Richardson, Donald L. Price, Mary Lou Voytko, Linda K. Gorman, Joseph R. Tobin, David S. Olton
Publikováno v:
The Journal of Neuroscience. 14:167-186
Cognitive impairments in humans and animals have been linked to dysfunction of neurons in the basal forebrain cholinergic system (BFCS). Degeneration of these cells may be, in part, responsible for some of the cognitive deficits observed in Alzheimer
Publikováno v:
Neuroscience Letters. 166:199-202
The medial septal area (MSA) contains cholinergic and GABAergic neurons that send projections to the hippocampus. These neurons have both cholinergic and GABAergic receptors. This study was designed to determine the effects of intraseptal infusions o
Autor:
Linda K. Gorman
Publikováno v:
Neurobiology of Aging. 14:699-702
Autor:
Daniel L. Alkon, David G. Amaral, Mark F. Bear, Joel Black, Thomas J. Carew, Neal J. Cohen, John F. Disterhoft, Howard Eichenbaum, Stephanie Golski, Linda K. Gorman, Gary Lynch, Bruce L. McNaughton, Mortimer Mishkin, James R. Moyer, James L. Olds, David S. Olton, Tim Otto, Larry R. Squire, Ursula Staubli, Lucien T. Thompson, Cynthia Wible
Publikováno v:
Alkon, DL; Amaral, DG; Bear, MF; Black, J; Carew, TJ; Cohen, NJ; et al.(1991). Learning and memory. Brain Research Reviews, 16(2), 193-220. doi: 10.1016/0165-0173(91)90005-S. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7qv2s1fq
Autor:
Steven J. Breckler, Alicja L. Markowska, Donald L. Price, Karyn M. Frick, Linda K. Gorman, Mark G. Baxter
Publikováno v:
Neuroscience. 89(3)
The nature of age-related changes in cholinergic function and their relationship to age-related behavioral decline were examined in the present study. Male Fischer-344 rats of four ages (four, 11, 17 and 23 months) were tested in a battery of cogniti
Publikováno v:
Journal of neurotrauma. 13(8)
Rats subjected to a mild to moderate fluid percussion injury exhibit memory deficits that are similar to rats that have received lesions of the septohippocampal system. Because the cholinergic system plays a major role in septohippocampal function, w
Autor:
Thomas J. Sobel, Michela Gallagher, David J. Bucci, Linda K. Gorman, Mark G. Baxter, Megan J. Williams
Publikováno v:
Neuroreport. 7(8)
The role of the basal forebrain cholinergic system in learning and memory has held considerable interest since the discovery of cholinergic neurodegeneration in the basal forebrain in Alzheimer's disease. Contrary to expectation, selective removal of