Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Linda K. Friedman"'
Publikováno v:
Molecular and Cellular Neuroscience. 98:54-69
Early life traumas lead to neuroprotection by preconditioning mechanisms. To determine which genes and pathways are most likely involved in specific adaptive effects, immature hippocampal cultures were exposed to a single high dose of glutamate (250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb5d2bc47a73d61320d3b65e143c426
https://doi.org/10.1016/j.mcn.2019.05.002
https://doi.org/10.1016/j.mcn.2019.05.002
Autor:
Linda K Friedman, Joann P Wongvravit
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 77:904-919
Anticonvulsant effects of cannabidiol (CBD), a nonpsychoactive cannabinoid, have not been investigated in the juvenile brain. We hypothesized that CBD would attenuate epileptiform activity at an age when the brain first becomes vulnerable to neurotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebfe8320a22163c5176c816c19c35d8
https://doi.org/10.1093/jnen/nly069
https://doi.org/10.1093/jnen/nly069
Autor:
Shirley Hu, Linda K Friedman
Publikováno v:
Life Sciences. 94:92-98
Although seizures are known to be harmful, recent evidence indicates that they can also lead to adaptations that protect neurons from further insult. For example, a history of two episodes of status epilepticus during a critical period of early devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726740f4efecdc8f29cfc9984ebb679d
https://doi.org/10.1016/j.lfs.2013.11.003
https://doi.org/10.1016/j.lfs.2013.11.003
Autor:
Linda K Friedman, Brandon Kahen
Publikováno v:
Behavioural Brain Research. 374:112046
The diagnosis of autism spectrum disorder (ASD) varies from very mild to severe social and cognitive impairments. We hypothesized that epigenetic subconvulsive activity in early postnatal life may contribute to the development of autistic behavior in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5e0d512289e8aa348823702d801df4
https://doi.org/10.1016/j.bbr.2019.112046
https://doi.org/10.1016/j.bbr.2019.112046
Publikováno v:
Epilepsy & Behavior. 29:466-477
Clinical and experimental studies have shown that many common secondary antiepileptic drugs (AEDs) are ineffective at blocking seizures in adulthood; however, some afford neuroprotection. In early development, certain AEDs cause apoptosis; however, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ff7e2008f88084676b175a6ec28cfc
https://doi.org/10.1016/j.yebeh.2013.08.019
https://doi.org/10.1016/j.yebeh.2013.08.019
Publikováno v:
NeuroMolecular Medicine. 9:298-314
NMDA receptors (NMDARs) are important for the propagation of seizures. To understand the role of NR1 subunits in the propagation of seizures we knocked down the NR1 subunit by intracranial injection of antisense deoxyoligonucleotides (NR1-AS-ODNs) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f8cc62c47f9259b8dd654beb07a72a
https://doi.org/10.1007/s12017-007-8009-7
https://doi.org/10.1007/s12017-007-8009-7
Publikováno v:
Brain Research. 1145:56-65
During a critical period of postnatal development the epileptogenic focus is thought to be of cortical origin. We used immunohistochemistry and Western blotting to elucidate potential mechanisms underlying an increased state of susceptibility to seiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ea76e1744cf72e75cac9d6648f28d5
https://doi.org/10.1016/j.brainres.2007.01.110
https://doi.org/10.1016/j.brainres.2007.01.110
Publikováno v:
Experimental Neurology. 202:100-111
The effects of repeated neonatal seizures on metabotropic glutamate receptors (mGluRs) during critical periods of brain development are unknown. Therefore, we characterized the expression of Group I (mGluR1 and mGluR5) and Group II (mGluR2/3) metabot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394efdb4c071640889a840bf193fd62e
https://doi.org/10.1016/j.expneurol.2006.05.033
https://doi.org/10.1016/j.expneurol.2006.05.033
Publikováno v:
Experimental Neurology. 184:196-213
Seizures increase dentate granule cell proliferation in adult rats but decrease proliferation in young pups. The particular period and number of perinatal seizures required to cause newborn granule cell suppression in development are unknown. Therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5527549eda6ae940e4befc048a3cef
https://doi.org/10.1016/s0014-4886(03)00207-3
https://doi.org/10.1016/s0014-4886(03)00207-3
Publikováno v:
International Journal of Developmental Neuroscience. 21:245-254
The substantia nigra pars reticulata (SNR) is involved in the control of movement disorders including seizures through its GABAergic neurons. Microinfusions of muscimol (a GABA(A) receptor agonist) produce specific effects on seizures depending on se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfc72e7dc8244f61810d14b71091710
https://doi.org/10.1016/s0736-5748(03)00069-8
https://doi.org/10.1016/s0736-5748(03)00069-8