Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Linda K. Clayton"'
Autor:
Howard Yan, Thomas M. Roberts, Christine Fritsch, Kira Gritsman, Gregory Hollingworth, Tulasi Khandan, Rachel Okabe, Christine Choi, Thanh Von, Mahnaz Paktinat, Haluk Yuzugullu, Linda K. Clayton, Sauveur Michel Maira, Jean J. Zhao
Publikováno v:
Journal of Clinical Investigation. 124:1794-1809
The genes encoding RAS family members are frequently mutated in juvenile myelomonocytic leukemia (JMML) and acute myeloid leukemia (AML). RAS proteins are difficult to target pharmacologically; therefore, targeting the downstream PI3K and RAF/MEK/ERK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b981165f425570fcd63e50d72f587b82
https://doi.org/10.1172/jci69927
https://doi.org/10.1172/jci69927
IκBNS Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor
Autor:
Ingo Schmitz, Michaela Annemann, Tim Sparwasser, Marc Schuster, Klaus Schulze-Osthoff, Linda K. Clayton, Britta Siegmund, Stefan Floess, Klaus Pfeffer, Jochen Huehn, Anja A. Kühl, Rainer Glauben, Carlos Plaza-Sirvent, Lisa Schreiber
Publikováno v:
Immunity. 37(6):998-1008
Summary Forkhead box P3 positive (Foxp3 + ) regulatory T (Treg) cells suppress immune responses and regulate peripheral tolerance. Here we show that the atypical inhibitor of NFκB (IκB) IκB NS drives Foxp3 expression via association with the promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86363748604eab5e3caa896f28782803
Autor:
Fanny Mann, Wesam B. Ahmed, Linda K. Clayton, Jonathan A. Epstein, Ellis L. Reinherz, Young I. Choi, Jonathan S. Duke-Cohan, Maris Handley
Publikováno v:
Immunity. 29:888-898
SummaryPrecise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7178357ac9ee3072e0c90a5a6a1b38
https://doi.org/10.1016/j.immuni.2008.10.008
https://doi.org/10.1016/j.immuni.2008.10.008
Autor:
Stephanie L. Osborn, Maki Touma, John E. Connolly, Linda K. Clayton, Derin B. Keskin, Michael J. Grusby, Valeria Antonini, Ellis L. Reinherz, April M. Bobenchik, Manoj Kumar
Publikováno v:
The Journal of Immunology. 179:1681-1692
Triggering of the TCR by cognate peptide/MHC ligands induces expression of I kappa BNS, a member of the I kappa B family of NF-kappaB inhibitors whose expression is associated with apoptosis of immature thymocytes. To understand the role of I kappa B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d1ac572d8fb8ffad81b48cb538b93d
https://doi.org/10.4049/jimmunol.179.3.1681
https://doi.org/10.4049/jimmunol.179.3.1681
Autor:
Jing Ni, Thanh Von, Jean J. Zhao, Kira Gritsman, Haluk Yuzugullu, Roderick T. Bronson, Lukas Baitsch, Haoxuan Tong, Linda K. Clayton, Thomas M. Roberts, Allison Steiner
Publikováno v:
Nature Communications
The tumour suppressor PTEN, which antagonizes PI3K signalling, is frequently inactivated in haematologic malignancies. In mice, deletion of PTEN in haematopoietic stem cells (HSCs) causes perturbed haematopoiesis, myeloproliferative neoplasia (MPN) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3cafd8581eea8b319b590b5b28bce0
http://europepmc.org/articles/PMC4598950
http://europepmc.org/articles/PMC4598950
Autor:
Linda K. Clayton, Hsiu-Ching Chang, Maris Handley, Ellis L. Reinherz, Tetsuro Sasada, Maki Touma
Publikováno v:
The Journal of Immunology. 176:6812-6823
The TCRβ chain constant domain contains an unusually elongated, solvent-exposed FG loop. This structural element forms one component of an αβ TCR cavity against which CD3εγ may abut to facilitate Ag-specific signaling. Consistent with this notio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f22e291b84c22d1199df057be6b1b043
https://doi.org/10.4049/jimmunol.176.11.6812
https://doi.org/10.4049/jimmunol.176.11.6812
Autor:
Christoph Plass, Daniel G. Tenen, Björn Hackanson, Linda K. Clayton, Joseph R. Tumang, Koichi Akashi, Bronwyn M. Owens, Achim Leutz, Ulrich Steidl, Katharina Wagner, Marina Scheller, Li Yu, Hiromi Iwasaki, Chunhui Liu, Frank Rosenbauer, Thomas L. Rothstein, Jeffery L. Kutok
Publikováno v:
Nature Genetics. 38:27-37
Tight regulation of transcription factors, such as PU.1, is crucial for generation of all hematopoietic lineages. We previously reported that mice with a deletion of an upstream regulatory element (URE) of the gene encoding PU.1 (Sfpi1) developed acu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898d3e46ee4cd8d6e471c221697f4e21
https://doi.org/10.1038/ng1679
https://doi.org/10.1038/ng1679
Autor:
Ingo Schmitz, Stephanie L. Osborn, Pedro A. Reche, Maki Touma, Elena V. Tibaldi, Ellis L. Reinherz, Wilfred E. Marissen, Emma Fiorini, Ada M. Kruisbeek, Linda K. Clayton, Rebecca E. Hussey, Tetsuro Sasada
Publikováno v:
Molecular Cell. 9(3):637-648
Negative selection eliminates thymocytes bearing autoreactive T cell receptors (TCR) via an apoptotic mechanism. We have cloned an inhibitor of NF-kappa B, I kappa BNS, which is rapidly expressed upon TCR-triggered but not dexamethasone- or gamma irr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb969572c7c647f06703f1d213aea75
Publikováno v:
International Immunology. 9:1475-1480
A rearranged TCR alpha transgene remains transcriptionally inactive in rag-2-/- thymocytes but can be induced by CD3-mediated signals with concomitant maturation of double-negative (DN) thymocytes to the CD4+CD8+ double-positive (DP) stage. Reciproca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d02f578bbb28ad53fe6ddf8f7f2a77
https://doi.org/10.1093/intimm/9.10.1475
https://doi.org/10.1093/intimm/9.10.1475
Autor:
Emiko Mizoguchi, Timothy D. Ocain, Linda K. Clayton, Yoseph Ghendler, Vishva M. Dixit, Kim Orth, Raymond J. Patch, Atul K. Bhan, Ellis L. Reinherz
Publikováno v:
The EMBO Journal. 16:2282-2293
T-cell receptors (TCRs) are created by a stochastic gene rearrangement process during thymocyte development, generating thymocytes bearing useful, as well as unwanted, specificities. Within the latter group, autoreactive thymocytes arise which are su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204c563ad0b6e70ec188cbcbb467c965
https://doi.org/10.1093/emboj/16.9.2282
https://doi.org/10.1093/emboj/16.9.2282