Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Linda K Kwong"'
Autor:
Alexandre Amlie-Wolf, Paul Ryvkin, Rui Tong, Isabelle Dragomir, EunRan Suh, Yan Xu, Vivianna M Van Deerlin, Brian D Gregory, Linda K Kwong, John Q Trojanowski, Virginia M-Y Lee, Li-San Wang, Edward B Lee
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141836 (2015)
TAR DNA-binding protein 43 (TDP-43) is normally a nuclear RNA-binding protein that exhibits a range of functions including regulation of alternative splicing, RNA trafficking, and RNA stability. However, in amyotrophic lateral sclerosis (ALS) and fro
Externí odkaz:
https://doaj.org/article/75384d272ab04139a4eeeb667d26f13a
Autor:
Sílvia Porta, Linda K. Kwong, John Q. Trojanowski, Edward B. Lee, Hannah J. Brown, Yan Xu, Virginia M.-Y. Lee, Clark R. Restrepo, Bin Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications
Nature Communications
The stereotypical distribution of TAR DNA-binding 43 protein (TDP-43) aggregates in frontotemporal lobar degeneration (FTLD-TDP) suggests that pathological TDP-43 spreads throughout the brain via cell-to-cell transmission and correlates with disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dae3500b7e7391ce4ee1cbc714827df
https://doaj.org/article/92900ea31995481996608cd988369b83
https://doaj.org/article/92900ea31995481996608cd988369b83
Autor:
Linda K. Kwong, Lior Rennert, Murray Grossman, John Q. Trojanowski, Ahmed Yousef, Matthew D. Byrne, EunRan Suh, Yan Xu, Vivianna M. Van Deerlin, Sharon X. Xie, Virginia M.-Y. Lee, Edward B. Lee, John L. Robinson, David J. Irwin
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-15 (2017)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as accompanying neuron loss. We explored if cortical neurons detected by Ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04975e26001617977f030af8f799eb98
http://link.springer.com/article/10.1186/s40478-017-0471-3
http://link.springer.com/article/10.1186/s40478-017-0471-3
Autor:
Edward B. Lee, G. Michael Baer, Lauren Elman, Murray Grossman, John Q. Trojanowski, EunRan Suh, Sílvia Porta, Linda K. Kwong, Virginia M.-Y. Lee, David J. Irwin, Yan Xu, Vivianna M. Van Deerlin
Publikováno v:
Acta Neuropathologica. 134:65-78
Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) can typically be categorized into one of four distinct histopathologic patterns of TDP-43 pathology, types A to D. The strength of this histopathologic classification lies in the ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dd7d588cd2ce3e5c4fd6857f2d6b92
https://doi.org/10.1007/s00401-017-1679-9
https://doi.org/10.1007/s00401-017-1679-9
Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases
Autor:
Murray Grossman, Gabor G. Kovacs, David J. Irwin, John Q. Trojanowski, EunRan Suh, Edward B. Lee, Linda K. Kwong, John L. Robinson, Virginia M.-Y. Lee, Vivianna M. Van Deerlin
Publikováno v:
Brain Pathology. 28:274-283
Tauopathies are a major group of neurodegenerative proteinopathies characterized by the accumulation of abnormal and hyperphosphorylated tau proteins in the brain. Tau pathology is characterized as 3R (repeat) or 4R predominant or mixed 3R and 4R typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817e792f273ed1c8ac949633091152d2
https://doi.org/10.1111/bpa.12482
https://doi.org/10.1111/bpa.12482
Autor:
Linda K. Kwong, Anna Stieber, Krista Spiller, Clark R. Restrepo, Virginia M.-Y. Lee, Claudia Cheung, John Q. Trojanowski
Publikováno v:
Journal of Neuroscience. 36:7707-7717
Motor neurons (MNs) are the neuronal class that is principally affected in amyotrophic lateral sclerosis (ALS), but it is widely known that individual motor pools do not succumb to degeneration simultaneously. Because >90% of ALS patients have an acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f03d25391034e9bcf97d74ac8894ee
https://doi.org/10.1523/jneurosci.1457-16.2016
https://doi.org/10.1523/jneurosci.1457-16.2016
Autor:
Adam K. Walker, Virginia M.-Y. Lee, Linda K. Kwong, Guanghui Ge, Kalyan Tripathy, John Q. Trojanowski, Melissa Zhou, Krista Spiller, Allen Zheng, Yan Xu
Publikováno v:
Acta Neuropathologica. 130:643-660
Accumulation of phosphorylated cytoplasmic TDP-43 inclusions accompanied by loss of normal nuclear TDP-43 in neurons and glia of the brain and spinal cord are the molecular hallmarks of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar deg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746d5741ad97beafc8c804c9b1ab4d6e
https://doi.org/10.1007/s00401-015-1460-x
https://doi.org/10.1007/s00401-015-1460-x
Publikováno v:
Journal of Neuropathology and Experimental Neurology
Supplemental digital content is available in the text.
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are 2 neurodegenerative disorders that share clinical, genetic, and neuropathologic features. The presence of
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are 2 neurodegenerative disorders that share clinical, genetic, and neuropathologic features. The presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7555288012e2048031b121d32de4af6f
http://europepmc.org/articles/PMC4362478
http://europepmc.org/articles/PMC4362478
Autor:
Corey T. McMillan, John Q. Trojanowski, Meredith Spindler, Murray Grossman, David J. Irwin, Linda K. Kwong, Charles Jester, David A. Wolk, Jeffrey S. Phillips, Katya Rascovsky, Ilya M. Nasrallah, Edward B. Lee, Virginia M.-Y. Lee, Kylie Ternes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20015a46ccaa7b394ae179696d589713
https://europepmc.org/articles/PMC5154298/
https://europepmc.org/articles/PMC5154298/
Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases
Autor:
Gabor G, Kovacs, Linda K, Kwong, Murray, Grossman, David J, Irwin, Edward B, Lee, John L, Robinson, Eunran, Suh, Vivianna M, Van Deerlin, Virginia M, Lee, John Q, Trojanowski
Publikováno v:
Brain Pathol
Tauopathies are a major group of neurodegenerative proteinopathies characterized by the accumulation of abnormal and hyperphosphorylated tau proteins in the brain. Tau pathology is characterized as 3R (repeat) or 4R predominant or mixed 3R and 4R typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b439fcca5785f343b327575c6c8ae31d
https://pubmed.ncbi.nlm.nih.gov/29516660
https://pubmed.ncbi.nlm.nih.gov/29516660