Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Linda K, Curtiss"'
Autor:
Yannan Zhao, Audrey S. Black, David J. Bonnet, Bruce E. Maryanoff, Linda K. Curtiss, Luke J. Leman, M. Reza Ghadiri
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2053-2063 (2014)
We have observed that molecular constructs based on multiple apoA-I mimetic peptides attached to a branched scaffold display promising anti-atherosclerosis functions in vitro. Building on these promising results, we now describe chronic in vivo studi
Externí odkaz:
https://doaj.org/article/4f3fefe053a342ae9ef59f6a82541f30
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1864-1875 (2014)
The objective of this study was to determine the combined effects of HL and cholesteryl ester transfer protein (CETP), derived exclusively from bone marrow (BM), on plasma lipids and atherosclerosis in high-fat-fed, atherosclerosis-prone mice. We tra
Externí odkaz:
https://doaj.org/article/794706e1be84431182df5df0ed202300
Autor:
Rogier A. van Dijk, Frank Kolodgie, Amir Ravandi, Gregor Leibundgut, Patrick P. Hu, Anand Prasad, Ehtisham Mahmud, Edward Dennis, Linda K. Curtiss, Joseph L. Witztum, Bruce A. Wasserman, Fumiyuki Otsuka, Renu Virmani, Sotirios Tsimikas
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 12, Pp 2773-2790 (2012)
The relationships between oxidation-specific epitopes (OSE) and lipoprotein (a) [Lp(a)] and progressive atherosclerosis and plaque rupture have not been determined. Coronary artery sections from sudden death victims and carotid endarterectomy specime
Externí odkaz:
https://doaj.org/article/e290b51a9e7e4581bcc078451e21baa7
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 10, Pp 2126-2132 (2012)
Atherosclerosis is a chronic inflammatory vascular disease. Toll-like receptors (TLRs) are major initiators of inflammation. TLR2 promotes atherosclerosis in LDL receptor (LDLr)-deficient mice fed a high-fat diet (HFD). TLR2 forms heterodimers with T
Externí odkaz:
https://doaj.org/article/65726d8790814465b787a669a157b0fe
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 10, Pp 1775-1786 (2011)
Through forward genetic screening in the mouse, a recessive mutation (couch potato, cpto) has been discovered that dramatically reduces plasma cholesterol levels across all lipoprotein classes. The cpto mutation altered a highly conserved residue in
Externí odkaz:
https://doaj.org/article/8717bb518dbf4f529a20f171ceb17b43
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 10, Pp 2113-2123 (2008)
In addition to hepatic expression, cholesteryl ester transfer protein (CETP) and hepatic lipase (HL) are expressed by human macrophages. The combined actions of these proteins have profound effects on HDL structure and function. It is not known how t
Externí odkaz:
https://doaj.org/article/735c66a1099a4f6a85a133b9b6ec0ce1
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 2, Pp 429-437 (2008)
Lystbeige mice crossed with hyperlipidemic low density lipoprotein receptor-deficient mice (BgLDLr−/−) display increased lesion area and a more stable lesion morphology. To verify that the beige phenotype is not unique to LDLr−/− mice, we exa
Externí odkaz:
https://doaj.org/article/36cfbe6f768448b2bbd9b1a8324d70e2
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 24-32 (2008)
Systemic phospholipid transfer protein (PLTP) is a recognized risk factor for coronary heart disease. In apolipoprotein E-deficient mice, systemic PLTP deficiency is atheroprotective, whereas PLTP overexpression is proatherogenic. As expected, we als
Externí odkaz:
https://doaj.org/article/abc34e90b93543e480aa4083952cbb31
Autor:
Matthias Schneider, Joseph L. Witztum, Stephen G. Young, Erwin H. Ludwig, Elizabeth R. Miller, Sotirios Tsimikas, Linda K. Curtiss, Santica M. Marcovina, John M. Taylor, Richard M. Lawn, Thomas L. Innerarity, Robert E. Pitas
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 4, Pp 769-778 (2005)
Efforts to elucidate the role of lipoprotein [a] (Lp[a]) in atherogenesis have been hampered by the lack of an animal model with high plasma Lp[a] levels. We produced two lines of transgenic mice expressing apolipoprotein [a] (apo[a]) in the liver an
Externí odkaz:
https://doaj.org/article/c7cddf410c7d4802996d9f55cdd11fad
Autor:
Peter Tobias, Linda K. Curtiss
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 3, Pp 404-411 (2005)
Atherosclerosis is a chronic inflammatory response characterized by the accumulation of cells of innate and acquired immune systems within the intima of the arterial wall. Macrophages are the predominant participant in innate immune responses in athe
Externí odkaz:
https://doaj.org/article/c7a14ed8d8b94a99a37638a482471889