Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Linda J. Risler"'
Autor:
Jeannine S. McCune, Sandi L. Navarro, Linda J. Risler, Brian R. Phillips, Suping Ren, H. Gary Schoch, K. Scott Baker
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 12, Pp 2577-2590 (2023)
Abstract Busulfan is hepatically metabolized through glutathione (GSH) conjugation; in vitro, this process depletes hepatocyte GSH stores and generates the cytotoxic metabolite γ‐glutamyldehydroalanylglycine, which is too unstable to be quantitate
Externí odkaz:
https://doaj.org/article/ceb3802b92a543fb95917bf8b6076114
Autor:
Joo Ha Hwang, Amy Chang, Sunil R. Hingorani, Afshin Mashadi-Hossein, Linda J. Risler, Jeannine S. McCune, Hong Chen, Frank Starr, Samantha D'Andrea, Tatiana D. Khokhlova, Yak-Nam Wang, Tong Li
Supplementary Figure Legends. Legends for Supplementary Figures S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b18622f0176ad04c0120fb854b3289
https://doi.org/10.1158/0008-5472.22407084
https://doi.org/10.1158/0008-5472.22407084
Autor:
Joo Ha Hwang, Amy Chang, Sunil R. Hingorani, Afshin Mashadi-Hossein, Linda J. Risler, Jeannine S. McCune, Hong Chen, Frank Starr, Samantha D'Andrea, Tatiana D. Khokhlova, Yak-Nam Wang, Tong Li
Supplementary Table S2. Estimated regression coefficients from equation 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7c7ab2d8416fe1bd0a2dc2fcf0e84e
https://doi.org/10.1158/0008-5472.22407069
https://doi.org/10.1158/0008-5472.22407069
Autor:
Joo Ha Hwang, Amy Chang, Sunil R. Hingorani, Afshin Mashadi-Hossein, Linda J. Risler, Jeannine S. McCune, Hong Chen, Frank Starr, Samantha D'Andrea, Tatiana D. Khokhlova, Yak-Nam Wang, Tong Li
Supplementary Figure S1. A multispectral image of an in vivo murine subcutaneous pancreatic tumor treated with pHIFU with varying levels of peak-rarefactional pressure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01843d7bafd7d3a1db5c8c72e4180342
https://doi.org/10.1158/0008-5472.22407081
https://doi.org/10.1158/0008-5472.22407081
Autor:
Joo Ha Hwang, Amy Chang, Sunil R. Hingorani, Afshin Mashadi-Hossein, Linda J. Risler, Jeannine S. McCune, Hong Chen, Frank Starr, Samantha D'Andrea, Tatiana D. Khokhlova, Yak-Nam Wang, Tong Li
Supplementary Materials and Methods. Description of additional methods and procedures used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ca0ae2656467f5669b762eb80794cb
https://doi.org/10.1158/0008-5472.22407075.v1
https://doi.org/10.1158/0008-5472.22407075.v1
Autor:
Joo Ha Hwang, Amy Chang, Sunil R. Hingorani, Afshin Mashadi-Hossein, Linda J. Risler, Jeannine S. McCune, Hong Chen, Frank Starr, Samantha D'Andrea, Tatiana D. Khokhlova, Yak-Nam Wang, Tong Li
Pancreatic cancer is characterized by extensive stromal desmoplasia, which decreases blood perfusion and impedes chemotherapy delivery. Breaking the stromal barrier could both increase perfusion and permeabilize the tumor, enhancing chemotherapy pene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d6188f07bec5af1cf3c6cdcdadfa89
https://doi.org/10.1158/0008-5472.c.6507228.v1
https://doi.org/10.1158/0008-5472.c.6507228.v1
Autor:
Jeannine S. McCune, Sandi L. Navarro, K. Scott Baker, Linda J. Risler, Brian R. Phillips, Timothy W. Randolph, Laura Shireman, H. Gary Schoch, H. Joachim Deeg, Yuzheng Zhang, Alex Men, Loes Maton, Alwin D. R. Huitema
Publikováno v:
Clinical pharmacology and therapeutics.
Intravenous (IV) busulfan doses are often personalized to a target plasma exposure (targeted busulfan) using an individual's busulfan clearance (BuCL). We evaluated whether BuCL could be predicted by a predose plasma panel of 841 endogenous metabolom
Autor:
Sophia E Airhart, Laura M Shireman, Linda J Risler, Gail D Anderson, G A Nagana Gowda, Daniel Raftery, Rong Tian, Danny D Shen, Kevin D O'Brien
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0186459 (2017)
OBJECTIVES:The co-primary objectives of this study were to determine the human pharmacokinetics (PK) of oral NR and the effect of NR on whole blood nicotinamide adenine dinucleotide (NAD+) levels. BACKGROUND:Though mitochondrial dysfunction plays a c
Externí odkaz:
https://doaj.org/article/118f428c45c544aba139a5573c94995f
Autor:
Laura M. Shireman, Linda J. Risler, Naveen K. Neradugomma, Bhagwat Prasad, Michael Z. Liao, Prachi Choudhari, Danny D. Shen, Qingcheng Mao, Brian Phillips, Chunying Gao
Publikováno v:
Pharmacological Research. 119:61-71
Norbuprenorphine is the major active metabolite of buprenorphine which is commonly used to treat opiate addiction during pregnancy. Norbuprenorphine produces marked respiratory depression and was 10 times more potent than buprenorphine. Therefore, it
Autor:
Lyrialle W. Han, Michael C. Cusumano, Linda J. Risler, Danny D. Shen, Mary F. Hebert, Brian Phillips, Rachel J. Ryu, Thomas R. Easterling
Publikováno v:
J Clin Pharmacol
Hydralazine, an antihypertensive agent used during pregnancy, undergoes N-acetylation primarily via N-acetyltransferase 2 (NAT2) to form 3-methyl-1,2,4-triazolo[3,4-a]phthalazine (MTP). To characterize the steady-state pharmacokinetics (PK) of hydral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cd13de5a93a5ddb80e736c2cffd5c6
https://europepmc.org/articles/PMC6813860/
https://europepmc.org/articles/PMC6813860/