Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Linda J. Reha-Krantz"'
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
DNA polymerases need to be engineered to achieve optimal performance for biotechnological applications, which often require high fidelity replication when using modified nucleotides and when replicating difficult DNA sequences. These tasks are achiev
Externí odkaz:
https://doaj.org/article/762da0d3e1cb457581ffe9a976bc1e6e
Autor:
Jessica N. McAlpine, C. Blake Gilks, David G. Huntsman, Cheng-Han Lee, Linda J. Reha-Krantz, Janine Senz, Winnie Yang, Derek Chiu, Samuel Leung, Aline Talhouk, Melissa K. McConechy
Purpose: The aim of this study was to confirm the prognostic significance of POLE exonuclease domain mutations (EDM) in endometrial carcinoma patients. In addition, the effect of treatment on POLE-mutated tumors was assessed.Experimental Design: A re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955b2784d139aaf08bb4b1a7d5049978
https://doi.org/10.1158/1078-0432.c.6524034.v1
https://doi.org/10.1158/1078-0432.c.6524034.v1
Autor:
Jessica N. McAlpine, C. Blake Gilks, David G. Huntsman, Cheng-Han Lee, Linda J. Reha-Krantz, Janine Senz, Winnie Yang, Derek Chiu, Samuel Leung, Aline Talhouk, Melissa K. McConechy
Supplemental methods Supplemental Table S1: Clinical characteristics of all POLE mutated and POLE wild-type endometrial carcinomas Supplemental Table S2: Clinical characteristics of POLE mutated and POLE wild-type endometrial carcinomas with associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a802423d6254aa5781784ea88d0ad18
https://doi.org/10.1158/1078-0432.22458762
https://doi.org/10.1158/1078-0432.22458762
Autor:
Myron F. Goodman, Linda J. Reha-Krantz
Publikováno v:
Genetics
John W. Drake died 02-02-2020, a mathematical palindrome, which he would have enjoyed, given his love of “word play and logic,” as stated in his obituary and echoed by his family, friends, students, and colleagues. Many aspects of Jan’s career
Publikováno v:
DNA Repair. 29:36-46
Proofreading by the bacteriophage T4 and RB69 DNA polymerases requires a β hairpin structure that resides in the exonuclease domain. Genetic, biochemical and structural studies demonstrate that the phage β hairpin acts as a wedge to separate the pr
Drug-Sensitive DNA Polymerase δ Reveals a Role for Mismatch Repair in Checkpoint Activation in Yeast
Autor:
Md. Shahjahan P. Siddique, Sam Lou, Charles Boone, Michelle O’Carroll, Kelly Murphy, Andrea Tam, Amy Schultz, Linda J. Reha-Krantz
Publikováno v:
Genetics. 189:1211-1224
We have used a novel method to activate the DNA damage S-phase checkpoint response in Saccharomyces cerevisiae to slow lagging-strand DNA replication by exposing cells expressing a drug-sensitive DNA polymerase δ (L612M-DNA pol δ) to the inhibitory
Autor:
Jeff Beckman, Linda J. Reha-Krantz, Chao Zhao, William H. Konigsberg, Shuangluo Xia, Usharani Subuddhi, Chithra Hariharan, Thomas D. Christian
Publikováno v:
Biochemistry. 50:10136-10149
The adenine base analogue 2-aminopurine (2AP) is a potent base substitution mutagen in prokaryotes because of its enhanceed ability to form a mutagenic base pair with an incoming dCTP. Despite more than 50 years of research, the structure of the 2AP-
Publikováno v:
Nucleic Acids Research
Polbase (http://polbase.neb.com) is a freely accessible database of DNA polymerases and related references. It has been developed in a collaborative model with experts whose contributions reflect their varied backgrounds in genetics, structural biolo
Autor:
Linda J. Reha-Krantz
Publikováno v:
Recent Patents on DNA & Gene Sequences. 2:145-163
Organisms with DNA genomes encode one or more DNA polymerases that are essential enzymes for chromosome replication, DNA repair and recombination. The ability of DNA polymerases to copy DNA templates has been exploited in a variety of in vitro reacti
Publikováno v:
Biochemistry. 47:6130-6137
For DNA polymerases to proofread a misincorporated nucleotide, the terminal 3-4 nucleotides of the primer strand must be separated from the template strand before being bound in the exonuclease active center. Genetic and biochemical studies of the ba