Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter

Autor: Max Patridge, Karin A. Oien, Reshma Shah, Nelofer Syed, Darren I. O'Brien, Louise Hiller, Clare Orange, Blanca Herrera, Paul Smith, Martino Monteverde, Milena Gasco, Francesca M. Buffa, Jelena Mann, Cristiana Lo Nigro, Meghan E. Maurer, Laura Lattanzio, Jonathan A. Cooper, Adrian L. Harris, Margaret C. Frame, Gabriela Kalna, Tim Crook, Linda J. Nicholson, Adele Hannigan, Lindsay C. Spender, David C. K. Chu, Catharine M L West, Johanna K. Thurlow, Gareth J. Inman

Publikováno v: Hannigan, A, Smith, P, Kalna, G, Lo Nigro, C, Orange, C, O'Brien, D I, Shah, R, Syed, N, Spender, L C, Herrera, B, Thurlow, J K, Lattanzio, L, Monteverde, M, Maurer, M E, Buffa, F M, Mann, J, Chu, D C K, West, C M L, Patridge, M, Oien, K A, Cooper, J A, Frame, M C, Harris, A L, Hiller, L, Nicholson, L J, Gasco, M, Crook, T & Inman, G J 2010, ' Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter ', Journal of Clinical Investigation, vol. 120, no. 8, pp. 2842-57 . https://doi.org/10.1172/JCI36125

The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4710c43c622a563e0be8cceeaa0a9c
https://doi.org/10.1172/jci36125

Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose?

Autor: Naomi Guppy, Linda J. Nicholson, Lim Sm, Malcolm R. Alison

Publikováno v: The Journal of Pathology. 222:335-344

Despite many years of intensive effort, there is surprisingly little consensus on the most suitable markers with which to locate and isolate stem cells from adult tissues. By comparison, the study of cancer stem cells is still in its infancy; so, uns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39786f000bfd3ccbae4711d96c20821c
https://doi.org/10.1002/path.2772

Ras-MEK-ERK signaling cascade regulates androgen receptor element-inducible gene transcription and DNA synthesis in prostate cancer cells

Autor: Rashida Pramanik, Gordon Muir, Anne Marie Carey, Jonathan D.H. Morris, Linda J. Nicholson, Francis Martin, Tracy Dew

Publikováno v: International Journal of Cancer. 121:520-527

Treatment of prostate cancer (CaP) patients frequently involves androgen ablation, but resistance often develops and androgen-insensitive tumors emerge. The molecular basis for the development of refractory CaP that grows in an androgen-independent m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16827cb82cce9b4c309314da1df136fc
https://doi.org/10.1002/ijc.22715

A Response to My 'Critics'

Autor: Linda J. Nicholson

Publikováno v: Hypatia. 16:86-90

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bedba9d96ce1fc4b1648990898308af8
https://doi.org/10.1353/hyp.2001.0026

Epstein-Barr virus latent membrane protein does not inhibit differentiation and induces tumorigenicity of human epithelial cells

Autor: I Johannessen, Linda J. Nicholson, David A. Thorley-Lawson, J. D. Codd, Jonathan R. Salisbury, Dorothy H Crawford, P Hopwood

Publikováno v: Oncogene. 15:275-283

Latent membrane protein (LMP) is a latent Epstein-Barr virus (EBV) protein expressed in the EBV associated malignancy, nasopharyngeal carcinoma (NPC). Properties ascribed to this protein include inhibition of epithelial cell differentiation and dereg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d7aabf271b0ff3270be1fe563e183a
https://doi.org/10.1038/sj.onc.1201187