Zobrazeno 1 - 2
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pro vyhledávání: '"Linda J. Kuhn"'
Publikováno v:
Proceedings of the National Academy of Sciences. 80:36-40
The phorbol diester receptor present in the particulate fraction of rat brain was solubilized by divalent ion chelation in the absence of detergents. The soluble receptor was partially purified by (NH4)2SO4 precipitation, DEAE-cellulose, and gel filt
Autor:
James Ebeling, Barry R. Ganong, Robert M. Bell, James E. Niedel, G. R. Vandenbark, Linda J. Kuhn
Publikováno v:
Proceedings of the National Academy of Sciences. 82:815-819
Activation of cellular protein kinase C appears to be involved in the mechanism by which phorbol diesters induce differentiation of human myeloid leukemia cells (HL-60). Protein kinase C is thought to be physiologically activated by diacylglycerol de