Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Linda J Wheeler"'
Autor:
Joshua C Saldivar, Satoshi Miuma, Jessica Bene, Seyed Ali Hosseini, Hidetaka Shibata, Jin Sun, Linda J Wheeler, Christopher K Mathews, Kay Huebner
Publikováno v:
PLoS Genetics, Vol 8, Iss 11, p e1003077 (2012)
Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration
Externí odkaz:
https://doaj.org/article/0438ea136d22470fb814e9264ecf0336
Publikováno v:
Journal of Biological Chemistry. 288:13145-13155
Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly asymmetric, and this asymmetry probably contributes to the elevated mutation rate for the mitochondrial genome as compared with the nuclear genome. To understand this asymmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee0c860c61967900ec0102c2bb2c546
https://doi.org/10.1074/jbc.m113.461111
https://doi.org/10.1074/jbc.m113.461111
Autor:
A. E. Berman, Donna S. Shewach, Nathalie C. Zeitouni, Mikhail A. Nikiforov, Anna Bianchi-Smiraglia, Katerina I. Leonova, Sudha Mannava, Joseph A. Wawrzyniak, Christopher K. Mathews, Kalyana Moparthy, Sheryl A. Flanagan, Andrei V. Gudkov, Linda J. Wheeler
Publikováno v:
Aging (Albany NY)
The down-regulation of dominant oncogenes, including C-MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC-depleted melanoma cells undergo ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fac83e502be3a86f0f3da93a5aa56ca
https://doi.org/10.18632/aging.100512
https://doi.org/10.18632/aging.100512
Autor:
Linda J. Wheeler, Michael Im, Dazhong Zhuang, Christopher K. Mathews, Mikhail A. Nikiforov, Sudha Mannava, Donna S. Shewach, Elena G. Slavina, Vladimir Grachtchouk
Publikováno v:
Cell Cycle. 7:2392-2400
To identify C-MYC targets rate-limiting for proliferation of malignant melanoma, we stably inhibited C-MYC in several human metastatic melanoma lines via lentivirus-based shRNAs approximately to the levels detected in normal melanocytes. C-MYC deplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1154cceb14971634195540c66b3419d
https://doi.org/10.4161/cc.6390
https://doi.org/10.4161/cc.6390
Publikováno v:
DNA Repair. 4:1450-1456
Intracellular pool sizes of deoxyribonucleoside triphosphates (dNTPs) are highly regulated. Unbalanced dNTP pools, created by abnormal accumulation or deficiency of one nucleotide, are known to be mutagenic and to have other genotoxic consequences. R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f05ca0fb7d78b6460ace53b8170fae2
https://doi.org/10.1016/j.dnarep.2005.09.003
https://doi.org/10.1016/j.dnarep.2005.09.003
Publikováno v:
Molecular Microbiology. 55:1502-1514
Our laboratory has reported data suggesting a role for T4 phage gene 32 single-stranded DNA-binding protein in organizing a complex of deoxyribonucleotide-synthesizing enzymes at the replication fork. In this article we examined the effects of gene 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::156c2997fb55dee1d5c0bc97fa483171
https://doi.org/10.1111/j.1365-2958.2004.04486.x
https://doi.org/10.1111/j.1365-2958.2004.04486.x
Publikováno v:
Journal of Biological Chemistry. 278:9345-9352
In Saccharomyces cerevisiae, many genes encoding enzymes involved in deoxyribonucleotide synthesis are expressed preferentially near the G1/S boundary of the cell cycle. The relationship between the induction of deoxyribonucleotide-synthesizing genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95ecec8a2c79a694ccfadf2dfed4f8d
https://doi.org/10.1074/jbc.m213013200
https://doi.org/10.1074/jbc.m213013200
Autor:
Linda J. Wheeler, Steven P. Angus, Erik S. Knudsen, Christopher K. Mathews, Sejal A. Ranmal, Michael P. Markey, Xiaoping Zhang
Publikováno v:
Journal of Biological Chemistry. 277:44376-44384
The retinoblastoma tumor suppressor, RB, is a negative regulator of the cell cycle that is inactivated in the majority of human tumors. Cell cycle inhibition elicited by RB has been attributed to the attenuation of CDK2 activity. Although ectopic cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9376b86db7f0d9eab775084b73014c
https://doi.org/10.1074/jbc.m205911200
https://doi.org/10.1074/jbc.m205911200
Publikováno v:
Current Biology. 17(17):R755-R757
Summary In addition to spellchecking during DNA replication and modulating recombination, DNA mismatch repair (MMR) promotes cytotoxic responses to certain DNA-damaging agents [1]. In mammalian cells, the best-studied response is to S n 1-type methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1608dbbfdcf2532ea3e3d4dc5ca74436
Autor:
Emily E. Fink, Christopher K. Mathews, Michael Im, Kalyana Moparthy, Sudha Mannava, Mikhail A. Nikiforov, Nathalie C. Zeitouni, Shoshanna N. Zucker, Donna S. Shewach, William C. Burhans, Sheryl A. Flanagan, Venkatesh Natarajan, Linda J. Wheeler
In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response. Oxidative stress and hyperreplication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here, we report that down-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5a53947f1a6515e175b944a6a4c53d
https://europepmc.org/articles/PMC3532713/
https://europepmc.org/articles/PMC3532713/
