Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Linda J Kay"'
Autor:
Paul V. Andrew, Abigail Pinnock, Anna Poyner, Kirsty Brown, John Chittock, Linda J. Kay, Michael J. Cork, Simon G. Danby
Publikováno v:
Dermatology and Therapy, Vol 14, Iss 2, Pp 391-408 (2024)
Abstract Introduction The skin of patients with atopic dermatitis (AD) is characterised by elevated pH. As a central homeostatic regulator, an increased pH accelerates desquamation and suppresses lipid processing, resulting in diminished skin barrier
Externí odkaz:
https://doaj.org/article/87c415aba9ee4804b5f0f130131cb024
Publikováno v:
Dermatology and Therapy, Vol 10, Iss 5, Pp 1031-1041 (2020)
Abstract Introduction The replenishment of skin lipids depleted in the dry skin state is a desirable therapeutic target to restore skin moisturization; however, there is limited evidence demonstrating the success of this approach through the use of t
Externí odkaz:
https://doaj.org/article/4e8eb110b22249e0a9225f6c90e20513
Autor:
Simon G. Danby, Paul V. Andrew, Linda J. Kay, Abigail Pinnock, John Chittock, Kirsty Brown, Samuel F. Williams, Michael J. Cork
Publikováno v:
British Journal of Dermatology. 186:875-886
The skin of patients with atopic dermatitis is characterized by abnormal stratum corneum lipid levels. Consequently, the lamellar matrices are disrupted and skin barrier function is diminished, increasing skin sensitivity to irritants and allergens.T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bdd86d049d63b4a57baeafb869c76e5
https://doi.org/10.1111/bjd.20955
https://doi.org/10.1111/bjd.20955
Publikováno v:
Dermatology and Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13dfbc0900a5c8c32bcac1d9ea6957b
https://doi.org/10.1007/s13555-021-00623-8
https://doi.org/10.1007/s13555-021-00623-8
Publikováno v:
Dermatology and Therapy, Vol 10, Iss 5, Pp 1031-1041 (2020)
Dermatology and Therapy
Dermatology and Therapy
Introduction The replenishment of skin lipids depleted in the dry skin state is a desirable therapeutic target to restore skin moisturization; however, there is limited evidence demonstrating the success of this approach through the use of topical em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a910ee8b6b26e1da1145b9b21665148
https://doaj.org/article/4e8eb110b22249e0a9225f6c90e20513
https://doaj.org/article/4e8eb110b22249e0a9225f6c90e20513
Autor:
Simon G. Danby, Paul V. Andrew, Rosie N. Taylor, Linda J. Kay, John Chittock, Abigail Pinnock, Intisar Ulhaq, Anna Fasth, Karin Carlander, Tina Holm, Michael J. Cork
Publikováno v:
Clinical and experimental dermatology. 47(6)
Summary Background Eczema (atopic dermatitis; AD) is a very common itchy skin condition affecting 1 in 5 children and up to 1 in 10 adults worldwide. The skin of eczema sufferers is prone to redness, irritation and dryness because it does not form an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dd0565e4979e6068c05066ec8134d8
https://pubmed.ncbi.nlm.nih.gov/35167133
https://pubmed.ncbi.nlm.nih.gov/35167133
Autor:
Linda J Kay, Ilona Obara
Publikováno v:
Inflammation Research
The 49th annual meeting of the European Histamine Research Society (EHRS) was planned to be held at 'Die Wolfsburg', Mühlheim an der Ruhr near Düsseldorf in Germany. With the announcement of the COVID-19 pandemic, the face-to-face conference meetin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a738924f1d3b203ea43541fd2752d9
Publikováno v:
European Journal of Pharmacology. 837:38-44
The diverse effects of histamine are mediated by discrete histamine receptors. The principal repository of histamine in the body is the mast cell. However, the effects of histamine on mast cells, especially those of human origin, have not been fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c43613596fbe3c76283fb61a3db9ab4
https://doi.org/10.1016/j.ejphar.2018.08.028
https://doi.org/10.1016/j.ejphar.2018.08.028
Autor:
Linda J Kay, Ahmed Iqbal, Simon Heller, Alan Bernjak, Peter Novodvorsky, Richard Jacques, Rory J. McCrimmon, Ian Sabroe, Lynne R. Prince, Fiona Wright, Danielle Lambert, Lewis Birch, Mark R Thomas, Sheila E. Francis, Robert F. Storey, Ian A. Macdonald
Publikováno v:
The Journal of Clinical Endocrinology and Metabolism
Context Hypoglycemia is emerging as a risk for cardiovascular events in diabetes. We hypothesized that hypoglycemia activates the innate immune system, which is known to increase cardiovascular risk. Objective To determine whether hypoglycemia modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa72d209a569b39eab5b735c1f2f9cf
https://doi.org/10.1210/jc.2018-01168
https://doi.org/10.1210/jc.2018-01168
Publikováno v:
European Journal of Pharmacology. 819:225-232
Mast cells are an exceptionally rich source of prostaglandin D2 (PGD2). PGD2 is pro-inflammatory and can cause bronchoconstriction. The enzyme cyclooxygenase (COX) is central to the generation of prostanoids such as PGD2. Non-steroidal anti-inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08a53fd4babdc8513c6c1b63ff674516
https://doi.org/10.1016/j.ejphar.2017.12.005
https://doi.org/10.1016/j.ejphar.2017.12.005