Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Linda Howard"'
Autor:
Yicheng Ding, Eva Carvalho, Cormac Murphy, Veronica McInerney, Janusz Krawczyk, Timothy O'Brien, Linda Howard, Li Cai, Sanbing Shen
Publikováno v:
Stem Cell Research, Vol 63, Iss , Pp 102850- (2022)
Externí odkaz:
https://doaj.org/article/9a1e0c3dd8c14e3bae6026a899ee6255
Autor:
Cameron Noah Keighron, Sahar Avazzadeh, Katarzyna Goljanek-Whysall, Brian McDonagh, Linda Howard, Thomas Ritter, Leo R. Quinlan
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 728 (2023)
Neurodegeneration is hallmarked by the progressive loss of dopaminergic neurons and/or a significant increase in protein aggregates in the brain. Neurodegenerative diseases are a leading cause of death worldwide with over 15 million people currently
Externí odkaz:
https://doaj.org/article/dbd244d7c52642f2ab5145ee621d14f4
Autor:
Yicheng Ding, Aisling O'Brien, Berta Marcó de la Cruz, Meimei Yang, Yin Lu, Xiaohong Qian, Guangming Yang, Veronica McInerney, Janusz Krawczyk, Sally A. Lynch, Linda Howard, Nicholas M. Allen, Timothy O'Brien, Louise Gallagher, Sanbing Shen
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102254- (2021)
NRXN1 deletions are commonly found in autism spectrum disorder (ASD) and other neurodevelopmental/neuropsychiatric disorders. Derivation of induced pluripotent stem cells (iPSCs) from different diseases involving different deletion regions are essent
Externí odkaz:
https://doaj.org/article/f9e86826ed454b82bf011cf698ad984b
Autor:
Yicheng Ding, Aisling O'Brien, Berta Marcó de la Cruz, Meimei Yang, Jacqueline Fitzgerald, Guangming Yang, Weidong Li, Veronica McInerney, Janusz Krawczyk, Sally A. Lynch, Linda Howard, Nicholas M. Allen, Timothy O'Brien, Louise Gallagher, Sanbing Shen
Publikováno v:
Stem Cell Research, Vol 52, Iss , Pp 102222- (2021)
NRXN1 encodes thousands of splicing variants categorized into long NRXN1α, short NRXN1β and extremely short NRXN1γ, which exert differential roles in neuronal excitation/inhibition. NRXN1α deletions are common in autism spectrum disorder (ASD) an
Externí odkaz:
https://doaj.org/article/e838199a5f194dc29c0e8c4705086fbb
Autor:
Yicheng Ding, Berta Marcó de la Cruz, Veronica McInerney, Yin Lu, Guangming Yang, Xiaohong Qian, Weidong Li, Janusz Krawczyk, Linda Howard, Timothy O'Brien, Louise Gallagher, Sanbing Shen
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102101- (2020)
The induced pluripotent stem cell (iPSC) technology has offered an unprecedented opportunity for disease modelling and drug discovery. Here we used non-integrating Sendai viral method and derived iPSCs from three young healthy Caucasian donors. All i
Externí odkaz:
https://doaj.org/article/45c95f48048348b58d7bf66f31e15452
Autor:
Berta Marcó de la Cruz, Yicheng Ding, Veronica McInerney, Janusz Krawczyk, Yin Lu, Guangming Yang, Xiaohong Qian, Weidong Li, Linda Howard, Nicholas M. Allen, Timothy O'Brien, Louise Gallagher, Sanbing Shen
Publikováno v:
Stem Cell Research, Vol 44, Iss , Pp - (2020)
Hundreds of rare risk factors have been identified for ASD, however, the underlying causes for ~70% of sporadic cases are unknown. Sporadic ASD models are thus essential for validating phenotypic commonality and drug suitability to the majority of pa
Externí odkaz:
https://doaj.org/article/4e7ba36deedd4a7aa63705ba1ab4d6c7
Autor:
Yicheng Ding, Eva Carvalho, Cormac Murphy, Veronica McInerney, Janusz Krawczyk, Timothy O'Brien, Linda Howard, Li Cai, Sanbing Shen
Publikováno v:
Stem Cell Research, Vol 43, Iss , Pp - (2020)
Retinitis Pigmentosa (RP) is an inherited disorder of retinal degeneration with progressive loss of rod and cone photoreceptors. RPE65 is a gene encoding the trans-cis isomerase which is essential for the classical visual cycle. While most RPE65 muta
Externí odkaz:
https://doaj.org/article/675c6f4f28d6479db515d17dd110784e
Autor:
Yicheng Ding, Berta Marcó de la Cruz, Yawen Xia, Min Liu, Yin Lu, Veronica McInerney, Janusz Krawczyk, Sally A. Lynch, Linda Howard, Timothy O'Brien, Louise Gallagher, Sanbing Shen
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
NRXN1 copy number variation is a rare genetic factor commonly shared among autism spectrum disorder (ASD), schizophrenia, intellectual disability, epilepsy and developmental delay. Human induced pluripotent stem cells (iPSCs) are essential for diseas
Externí odkaz:
https://doaj.org/article/2d8cecdca7964838860545db65b61e29
Publikováno v:
Cells, Vol 10, Iss 8, p 2102 (2021)
Spinal cord injury (SCI) is a devastating trauma that can cause permanent disability, life-long chronic issues for sufferers and is a big socioeconomic burden. Regenerative medicine aims to overcome injury caused deficits and restore function after S
Externí odkaz:
https://doaj.org/article/1a193b5448c4462f8ba02b371aadf194
Publikováno v:
Biology, Vol 9, Iss 3, p 54 (2020)
The failure of the spinal cord to regenerate can be attributed both to a lack of trophic support for regenerating axons and to upregulation of inhibitory factors such as chondroitin sulphate proteoglycans including NG2 following injury. Lentiviral ve
Externí odkaz:
https://doaj.org/article/7eb6da41a453437482ae355b09b7c5d4