Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Linda Hibbert"'
Autor:
Conor Hayes, Marine C.C. Raman, C.H. Coles, Stephen Harper, Linda Hibbert, Patrick J. Lupardus, David K. Cole, Angharad Lloyd, Catriona McMurran, Miriam Hock
Publikováno v:
The Journal of Biological Chemistry
T cell-mediated immunity is governed primarily by T cell receptor (TCR) recognition of peptide-human leukocyte antigen (pHLA) complexes and is essential for immunosurveillance and disease control. This interaction is generally stabilized by interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c26e82c5e591b3537bb07af2f9c07f8
https://doi.org/10.1074/jbc.ra120.014016
https://doi.org/10.1074/jbc.ra120.014016
Autor:
Maria Busz, Linda Hibbert, Luke Williams, Elizabeth E. Evans, Karolina Lech, Joseph Dukes, Annelise Vuidepot, Vanessa L. Clark, Sarah K. Bailey, Alice Barkell, Bent K. Jakobsen, Kathy Hale, Michelle Teng, Debbie E. Wright, Alasdair Gunn
Publikováno v:
Cancer Immunology Research. 8:B44-B44
ImmTAC (Immune mobilizing monoclonal TCRs against cancer) molecules are a new class of bi-specific biologic that combine a T-cell receptor (TCR)-targeting system with an anti-CD3 effector function to activate highly potent and specific T-cell respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e66605e7ed8d63d45c0d40fa19ee87a6
https://doi.org/10.1158/2326-6074.tumimm18-b44
https://doi.org/10.1158/2326-6074.tumimm18-b44
Autor:
Emma Hickman, Luise U. Weigand, Debbie Baker, Linda Hibbert, Annelise Vuidepot, Namir J. Hassan, Zoe Donnellan, Samantha Paston, Louise Conlon, Giovanna Bossi, Joseph Dukes, Ruth Simmons, Ruth Ryan, Caroline Boudousquie, Alex Powlesland, Vanessa L. Clark, Bent K. Jakobsen, Kathy Hale
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts Malignant cells may be recognised by T cells binding cell surface Class I HLA (Human Leukocyte Antigen)-peptide complexes presenting disease-associated epitopes. Many cancer patients have been shown to generate CD8 cytotoxic T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40a79b68a41a341e39f5c9a1e1daf7d
https://doi.org/10.1186/2051-1426-3-s2-p380
https://doi.org/10.1186/2051-1426-3-s2-p380
Autor:
Anna C. Barry, James A. Johnston, Gillian M. Tannahill, Joanne Elliott, Nicolas A. Cacalano, Linda Hibbert
Publikováno v:
Molecular and Cellular Biology. 25:9115-9126
Cytokine responses can be regulated by a family of proteins termed suppressors of cytokine signaling (SOCS) which can inhibit the JAK/STAT pathway in a classical negative-feedback manner. While the SOCS are thought to target signaling intermediates f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff2da6f46e983c6e1608dab3fc42ec6
https://doi.org/10.1128/mcb.25.20.9115-9126.2005
https://doi.org/10.1128/mcb.25.20.9115-9126.2005
Autor:
Linda Hibbert, Joseph H. Phillips, J. Fernando Bazan, Robert A. Kastelein, Elena Vaisberg, Rene de Waal Malefyt, Terrill K. McClanahan, Jeanine D. Mattson, Rency Rosales, Stefan Pflanz
Publikováno v:
The Journal of Immunology. 172:2225-2231
The recently discovered cytokine IL-27 belongs to the IL-6/IL-12 family of cytokines and induced proliferation of naive CD4+ T cells and the generation of a Th1-type adaptive immune response. Although binding of IL-27 to the cytokine receptor WSX-1 w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24a6c3afc3d41eacd02b6f7756a61d5
https://doi.org/10.4049/jimmunol.172.4.2225
https://doi.org/10.4049/jimmunol.172.4.2225
Autor:
Robert A. Kastelein, Christiaan J. M. Saris, Christopher A. Hunter, Linda A. Lieberman, Emma H. Wilson, Linda Hibbert, Hiroki Yoshida, Tak W. Mak, Alejandro V. Villarino
Publikováno v:
Immunity. 19(5):645-655
Although recent studies have described IL-27 and its receptor, WSX-1, as promoters of Th1 differentiation in naive CD4+ T cells, the data presented here indicate that signaling through this receptor is involved in limiting the intensity and duration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7974a05f061a36934519fe461106ae8b
Autor:
Graham R. Foster, Linda Hibbert
Publikováno v:
Journal of Interferon & Cytokine Research. 19:309-318
We examined the effects of eight subtypes of human interferon-alpha (IFN-alpha) and human IFN-beta on primary human B cells. In costimulation with antibodies to IgM (but not to CD40), some of these induced the cells to proliferate (but not to differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7af16ec06ec435d55cadc3b5baf5cc0
https://doi.org/10.1089/107999099314009
https://doi.org/10.1089/107999099314009
Autor:
Joerg F. Schlaak, Graham R. Foster, Andrew D. Davidson, Simon Ball, Michael Jacobs, Linda Hibbert, Meleri Jones, Petra Gruenwald
Publikováno v:
Journal of Virology, 79 (9) pp. 5414-5420. (2005)
Alpha/beta interferon (IFN-α/β) is a key mediator of innate antiviral responses but has little effect on the established replication of dengue viruses, which are mosquito-borne flaviviruses of immense global health importance. Understanding how the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7f09ec4f691e957441b309ffb17de3
https://europepmc.org/articles/PMC1082737/
https://europepmc.org/articles/PMC1082737/
Publikováno v:
Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 23(9)
Interleukin-27 (IL-27) supports proliferation of naive CD4(+) T cells and enhances interferon-gamma (IFN-gamma) production by activated T cells and natural killer (NK) cells. We report here that IL-27 induces Stat1 and Stat3 phosphorylation and activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4cfafa18b56f777bf61e3f48f2a0208
https://pubmed.ncbi.nlm.nih.gov/14565860
https://pubmed.ncbi.nlm.nih.gov/14565860
Autor:
Linda Hibbert, James A. Johnston
Publikováno v:
Expert opinion on therapeutic targets. 5(6)
Cytokines mediate their response via cell surface receptors that in turn activate intracellular signalling pathways and lead to gene activation, cell proliferation and differentiation. Many recent studies have shown that cytokine and cytokine recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e076eebcf0c9c7e97209fa2dad123bb0
https://pubmed.ncbi.nlm.nih.gov/12540275
https://pubmed.ncbi.nlm.nih.gov/12540275