Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Linda H.L. Lua"'
Autor:
Fabian B. H. Rehm, Simon J. de Veer, Linda H.L. Lua, Shyn Ric Tang, Yan Zhou, Conan K. Wang, Thomas Durek, David J. Craik, Junqiao Du, Kuok Yap, Jing Xie
Publikováno v:
Nature Protocols. 16:1740-1760
Cyclic disulfide-rich peptides have attracted significant interest in drug development and biotechnology. Here, we describe a protocol for producing cyclic peptide precursors in Pichia pastoris that undergo in vitro enzymatic maturation into cyclic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78359db5bb7f40ba35d5152773d88949
https://doi.org/10.1038/s41596-020-00483-0
https://doi.org/10.1038/s41596-020-00483-0
Autor:
David J. Craik, Fabian B. H. Rehm, Anuja R. Bony, Kuok Yap, Shyn Ric Tang, Simon J. de Veer, Junqiao Du, Fong Yang Looi, Conan K. Wang, David J. Adams, Jing Xie, Linda H.L. Lua, Lai Yue Chan, Thomas Durek
Publikováno v:
Green Chemistry. 22:5002-5016
Macrocyclic, disulfide-rich peptides have found widespread applications in drug design and development. Current peptide production strategies rely heavily on solid phase peptide synthesis (SPPS) requiring large amounts of hazardous/toxic reagents and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a7383e9423cf392e3c3b6663a8b56b
https://doi.org/10.1039/d0gc01366h
https://doi.org/10.1039/d0gc01366h
Autor:
Andreas Suhrbier, Victoria Ozberk, Yoshihiro Kawaoka, Adetayo A. Adeniyi, Benjamin Evert, Linda H.L. Lua, Michael F. Good, Bernd H. A. Rehm, Shuxiong Chen, Mercè Salla-Martret, Manisha Pandey, Peter Halfmann
Publikováno v:
Advanced Healthcare Materials
There is an unmet need for safe and effective severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines that are stable and can be cost‐effectively produced at large scale. Here, a biopolymer particle (BP) vaccine technology that ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ef8c1268d8503aeab2bcaeffae850e
https://pubmed.ncbi.nlm.nih.gov/34716678
https://pubmed.ncbi.nlm.nih.gov/34716678
Publikováno v:
Chemico-Biological Interactions. 363:109996
Organophosphorus nerve agents represent a serious chemical threat due to their ease of production and scale of impact. The recent use of the nerve agent Novichok has re-emphasised the need for broad-spectrum medical countermeasures (MCMs) to these ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5a2c03915d275783097101d8a62d68
https://doi.org/10.1016/j.cbi.2022.109996
https://doi.org/10.1016/j.cbi.2022.109996
Autor:
Manuel J.T. Carrondo, Anton P. J. Middelberg, Linda H.L. Lua, João Vidigal, António Roldão, Hayley K. Charlton Hume
Publikováno v:
Biotechnology and Bioengineering
Vaccination is the most effective method of disease prevention and control. Many viruses and bacteria that once caused catastrophic pandemics (e.g., smallpox, poliomyelitis, measles, and diphtheria) are either eradicated or effectively controlled thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e818b10bd5af510f755f7cf2786fcf5
https://doi.org/10.1002/bit.26890
https://doi.org/10.1002/bit.26890
Publikováno v:
Biotechnology and Bioengineering. 115:2893-2907
Rapid advances in intensifying upstream processes for biologics production have left downstream processing as a bottleneck in the manufacturing scheme. Biomanufacturers are pursuing continuous downstream process development to increase efficiency and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56dbfbfec0dfd7002a5c48df92552ee
https://doi.org/10.1002/bit.26812
https://doi.org/10.1002/bit.26812
Autor:
Patrick H.N. Celie, Georg Huber, Christian Benda, Anita Lehner, Hüseyin Besir, Cindy Chang, Paola Storici, Peggy Stolt-Bergner, Joop van den Heuvel, Astrid Sander, Gwynn Pardee, Sabine Suppmann, Regis P. Lemaitre, Barbara Giabbai, Wolfgang Knecht, Isabel Zaror, Daniel Weinbruch, Linda H.L. Lua, Tim Bergbrede, Ines Racke, Judith Scholz, David N. Drechsel, Arie Geerlof, Magda Stadnik, Ariane Fischer, Kristina Nordén, Kim Remans
Publikováno v:
J. Struct. Biol. 203, 71-80 (2018)
Baculovirus-insect cell expression system has become one of the most widely used eukaryotic expression systems for heterologous protein production in many laboratories. The availability of robust insect cell lines, serum-free media, a range of vector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ca00a22d4e1f9346a9509793321a5c
https://doi.org/10.1016/j.jsb.2018.03.004
https://doi.org/10.1016/j.jsb.2018.03.004
Autor:
Sreeman K. Mamidyala, Peter Koopman, Yann Gambin, Robert J. Capon, Kirill Alexandrov, Angela A. Salim, Avril A. B. Robertson, Johannes Zuegg, Mehdi Moustaqil, Jeroen Overman, Kamesh Narasimhan, Emma Sierecki, Nina Prokoph, Frank Fontaine, Mark E. Cooper, Mathias Francois, Ralf Jauch, Linda H.L. Lua
Publikováno v:
Cell Chemical Biology. 24:346-359
Pharmacological modulation of transcription factors (TFs) has only met little success over the past four decades. This is mostly due to standard drug discovery approaches centered on blocking protein/DNA binding or interfering with post-translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2e215b45124a62fec1988585cb58f0
https://doi.org/10.1016/j.chembiol.2017.01.003
https://doi.org/10.1016/j.chembiol.2017.01.003
Publikováno v:
Vaccine
Improved understanding of antigenic components and their interaction with the immune system, as supported by computational tools, permits a sophisticated approach to modern vaccine design. Vaccine platforms provide an effective tool by which strategi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb78beeddb0b44b09c1caead530fcdfb
http://europepmc.org/articles/PMC7115529
http://europepmc.org/articles/PMC7115529
Autor:
Il Gyu Kong, Nani Wibowo, Yong-Soo Lee, Su-Hyun Lee, Arjun Seth, Yeji Kim, Jin-Young Yang, Linda H.L. Lua, Anton P. J. Middelberg, Mi-Na Kweon
Publikováno v:
Vaccine. 34:6472-6480
Infection with Group A streptococcus (GAS)-an oropharyngeal pathogen-leads to mortality and morbidity, primarily among developing countries and indigenous populations in developed countries. The development of safe and affordable GAS vaccines is chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123b1fe3b87163724ef744e28130ac66
https://doi.org/10.1016/j.vaccine.2016.11.008
https://doi.org/10.1016/j.vaccine.2016.11.008