Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Linda H. Younkin"'
Autor:
Suzanne Wahrle, Pritam Das, Andrew C. Nyborg, Chris McLendon, Mikio Shoji, Takeshi Kawarabayashi, Linda H. Younkin, Steven G. Younkin, Todd E. Golde
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 1, Pp 11-23 (2002)
Buoyant membrane fractions containing presenilin 1 (PS1), an essential component of the γ-secretase complex, and APP CTFβ, a γ-secretase substrate, can be isolated from cultured cells and brain by several different fractionation procedures that ar
Externí odkaz:
https://doaj.org/article/ebdcbebbdf1747b1a2a631b92cfc424f
Autor:
Linda H. Younkin, Steven G. Younkin
Publikováno v:
Nerve-Muscle Cell Trophic Communication ISBN: 9780429282430
Nerve-Muscle Cell Trophic Communication
Nerve-Muscle Cell Trophic Communication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5af2b22ad6670372fcc7b1070b874a
https://doi.org/10.1201/9780429282430-4
https://doi.org/10.1201/9780429282430-4
Autor:
Minerva M Carrasquillo, Olivia Belbin, Fanggeng Zou, Mariet Allen, Nilufer Ertekin-Taner, Morad Ansari, Samantha L Wilcox, Mariah R Kashino, Li Ma, Linda H Younkin, Samuel G Younkin, Curtis S Younkin, Toros A Dincman, Melissa E Howard, Chanley C Howell, Chloe M Stanton, Christopher M Watson, Michael Crump, Veronique Vitart, Caroline Hayward, Nicholas D Hastie, Igor Rudan, Harry Campbell, Ozren Polasek, Kristelle Brown, Peter Passmore, David Craig, Bernadette McGuinness, Stephen Todd, Patrick G Kehoe, David M Mann, A David Smith, Helen Beaumont, Donald Warden, Clive Holmes, Reinhard Heun, Heike Kölsch, Noor Kalsheker, V Shane Pankratz, Dennis W Dickson, Neill R Graff-Radford, Ronald C Petersen, Alan F Wright, Steven G Younkin, Kevin Morgan
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8764 (2010)
BACKGROUND:The insulin-degrading enzyme gene (IDE) is a strong functional and positional candidate for late onset Alzheimer's disease (LOAD). METHODOLOGY/PRINCIPAL FINDINGS:We examined conserved regions of IDE and its 10 kb flanks in 269 AD cases and
Externí odkaz:
https://doaj.org/article/30705a34921a465983afe4754bf3908f
Autor:
Linda H. Younkin, Josef Anrather, Rose Pistik, George Carlson, Michelle Murphy, Lidia Garcia-Bonilla, Steven Younkin, Laibaik Park, Costantino Iadecola, Kenzo Koizumi, Ping Zhou, Ken Uekawa
Publikováno v:
Circulation Research. 121:258-269
Rationale: Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer disease, the leading cause of late-life dementia. The amyloid-β peptide (Aβ), a key pathogenic factor in Alzheimer disease, indu
Autor:
Steven G. Younkin, Laibaik Park, Josef Anrather, Costantino Iadecola, Joan Zhou, Andrea J. Arreguin, George A. Carlson, Joseph P. Pierce, Linda H. Younkin, Rose Pistick, Ping Zhou, Bruce S. McEwen, Sleiman El Jamal
Publikováno v:
Proceedings of the National Academy of Sciences. 110:3089-3094
Deposition of amyloid-β (Aβ) in cerebral arteries, known as cerebral amyloid angiopathy (CAA), occurs both in the setting of Alzheimer’s disease and independent of it, and can cause cerebrovascular insufficiency and cognitive deficits. The mechan
Autor:
Linda H. Younkin, Robia G. Pautler, Juan Botas, Jeffrey L. Noebels, Valerie C. Bomben, Jerrah K. Holth, Taeko Inoue, Steven G. Younkin, J. Graham Reed
Publikováno v:
The Journal of Neuroscience. 33:1651-1659
Neuronal network hyperexcitability underlies the pathogenesis of seizures and is a component of some degenerative neurological disorders such as Alzheimer's disease (AD). Recently, the microtubule-binding protein tau has been implicated in the regula
Autor:
Prakash Vishnu, Steven G. Younkin, Michael J. Wehle, Winston Tan, Robert C. Smallridge, Neill R. Graff-Radford, Tanis J. Ferman, Linda H. Younkin, Steven J. Buskirk, Edgar G. Covil, Julia E. Crook, Michael G. Heckman
Publikováno v:
Urology. 81:150-154
Objective To investigate whether prostate cancer patients receiving leuprolide demonstrated objective cognitive decline accompanied by a change in plasma levels of amyloid-β. Methods Between November 19, 2003, and July 21, 2008, we prospectively enr
Autor:
Xianlin Han, Masaya Tachibana, Miao Wang, Fanggeng Zou, Yu Yamazaki, Yasumasa Ohyagi, Nobutaka Sakae, Romain Fol, Aishe Kurti, Minerva M. Carrasquillo, Jessica L. Frisch-Daiello, Daniel Sevlever, Linda H. Younkin, Ming Gan, Gina Bisceglio, Steven G. Younkin, Guojun Bu, Chia Chen Liu, John D. Fryer, Li Ma, Takahisa Kanekiyo, Michael L. Fitzgerald, Mitsuru Shinohara, Patrick Knight
In Alzheimer's disease (AD), the accumulation and deposition of amyloid-β (Aβ) peptides in the brain is a central event. Aβ is cleaved from amyloid precursor protein (APP) by β-secretase and γ-secretase mainly in neurons. Although mutations inAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52dc142d9f1256d2407afd5cc1fab2a1
https://europepmc.org/articles/PMC4812140/
https://europepmc.org/articles/PMC4812140/
Autor:
James P. Cleary, Roger Anwyl, Linda H. Younkin, Linda Kotilinek, Roi Ann Wallis, Sally A. Frautschy, Michael J. Rowan, Karen H. Ashe, Agnieszka M. Falinska, Steven G. Younkin, Sylvain Lesné, Grace Y. Sun, Giselle P. Lim, Qinwen Wang, Greg M. Cole, Marcus A. Westerman, Agnes Simonyi, Kimberly L. Panizzon
Publikováno v:
Brain. 131:651-664
Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia characterized by the accumulation of amyloid plaques containing the amyloid-beta protein (Abeta).
Autor:
Linda H. Younkin, Debra Yager, Sanjay Asthana, Francine Parfitt, Mike Hutton, Matt Baker, Steve Younkin, Nilufer Ertekin-Taner, Neil Graff-Radford
Publikováno v:
Neurology. 70:596-606
Objective: Plasma Aβ levels are elevated in early-onset Alzheimer disease (AD) caused by autosomal dominant mutations. Our objective was to determine whether similar genetic elevations exist in late-onset AD (LOAD). Methods: We measured plasma Aβ i