Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Linda Geironson"'
Autor:
Rebecca Warfvinge, Linda Geironson Ulfsson, Parashar Dhapola, Fatemeh Safi, Mikael Sommarin, Shamit Soneji, Henrik Hjorth-Hansen, Satu Mustjoki, Johan Richter, Ram Krishna Thakur, Göran Karlsson
Publikováno v:
eLife, Vol 12 (2024)
The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of
Externí odkaz:
https://doaj.org/article/d2afc990e3264278aae9d3f9ec4607bc
In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations
Autor:
Fatemeh Safi, Parashar Dhapola, Eva Erlandsson, Linda Geironson Ulfsson, Ariana S. Calderón, Charlotta Böiers, Göran Karlsson
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101965- (2023)
Summary: Here we describe an in vitro co-culture system that can differentiate hematopoietic progenitor populations to all major hematopoietic lineages at clonal level. We present both a sensitive single-cell switch-culture system as well as a less l
Externí odkaz:
https://doaj.org/article/5c57f55d5800494682503c01d97127a2
Autor:
Warfvinge, Rebecca, Ulfsson, Linda Geironson, Dhapola, Parashar, Safi, Fatemeh, Sommarin, Mikael, Soneji, Shamit, Hjorth-Hansen, Henrik, Mustjoki, Satu, Richter, Johan, Thakur, Ram Krishna, Karlsson, Göran
Publikováno v:
eLife; 11/6/2024, p1-27, 27p
In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations
Autor:
Safi, Fatemeh, Dhapola, Parashar, Erlandsson, Eva, Ulfsson, Linda Geironson, Calderón, Ariana S., Böiers, Charlotta, Karlsson, Göran
Publikováno v:
In STAR Protocols 17 March 2023 4(1)
Autor:
Victoria Junghans, Eva Freyhult, Kajsa M Paulsson, Elna Follin, Camilla Thuring, Mikkel Harndahl, Linda Geironson, Søren Buus
Publikováno v:
British Journal of Cancer
Background: Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cbc68a7e9b8abc3df1a97ad2d78ab5
http://europepmc.org/articles/PMC4578088
http://europepmc.org/articles/PMC4578088
Autor:
Ram Krishna Thakur, Parashar Dhapola, Mikael Sommarin, Fatemeh Safi, Ulrich Pfisterer, Rebecca Warfvinge, Johan Richter, Linda Geironson Ulfsson, Göran Karlsson
Publikováno v:
Blood. 134:4140-4140
In chronic myeloid leukemia (CML), a rare subset of leukemic stem cells (LSC) persists in patients responding to conventional tyrosine kinase inhibitor (TKI) therapy. The failure to eradicate these LSCs results in indefinite therapy dependence and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85dba1edfa7e8154a50ca0d0adef03f6
https://doi.org/10.1182/blood-2019-130956
https://doi.org/10.1182/blood-2019-130956
Autor:
Charlotta Böiers, anna Konturek, Mikael Sommarin, Eva Erlandsson, Linda Geironson Ulfsson, David Bryder, Göran Karlsson, parasha Dhapola
Publikováno v:
Experimental Hematology. 76:S52
Hematopoietic stem cells (HSCs) have the capacity to differentiate into all hematopoietic lineages, and at the same time self-renew to maintain the HSC pool. HSCs have been thoroughly investigated using immunophenotypic-, molecular- and functional-an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68165d7269c3180367c3d1e2dd5f9e3b
https://doi.org/10.1016/j.exphem.2019.06.311
https://doi.org/10.1016/j.exphem.2019.06.311
Autor:
Ulla Olsson-Strömberg, Christine Karlsson, Jesper Stentoft, Teona Roschupkina, Göran Karlsson, Leif Stenke, Shamit Soneji, Henrik Hjorth-Hansen, Linda Geironson, Rebecca Warfvinge, Johan Richter, Mikael Sommarin, Stefan Lang, Satu Mustjoki
Publikováno v:
Warfvinge, R, Geironson, L, Sommarin, M N E, Lang, S, Karlsson, C, Roschupkina, T, Stenke, L, Stentoft, J, Olsson-Stromberg, U, Hjorth-Hansen, H, Mustjoki, S, Soneji, S, Richter, J & Karlsson, G 2017, ' Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML ', Blood, vol. 129, no. 17, pp. 2384-2394 . https://doi.org/10.1182/blood-2016-07-728873
Understanding leukemia heterogeneity is critical for the development of curative treatments as the failure to eliminate therapy-persistent leukemic stem cells (LSCs) may result in disease relapse. Here we have combined high-throughput immunopheno-typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8068b71a2acb946c4703341d452f453f
https://pubmed.ncbi.nlm.nih.gov/28450572
https://pubmed.ncbi.nlm.nih.gov/28450572
Publikováno v:
FEBS Letters. 586:1336-1343
Only a small fraction of the peptides generated inside the cell end up being presented by HLA-I on the cell surface. High stability of peptide-HLA-I complexes and a low HLA-I tapasin-facilitation have been proposed to predict immunogenicity. We here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75db54e66679a9c717021cbc13a0183
https://doi.org/10.1016/j.febslet.2012.03.045
https://doi.org/10.1016/j.febslet.2012.03.045
Autor:
Linda Geironson, Gustav Røder, Mikkel Harndahl, Michael R. Rasmussen, Søren Buus, Kajsa M Paulsson
Publikováno v:
Journal of Biological Chemistry; 286(23), pp 20547-20557 (2011)
A plethora of peptides are generated intracellularly, and most peptide-human leukocyte antigen (HLA)-I interactions are of a transient, unproductive nature. Without a quality control mechanism, the HLA-I system would be stressed by futile attempts to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e54bf0dd268198dcaccbe3947ebc87b
https://doi.org/10.1074/jbc.m111.230151
https://doi.org/10.1074/jbc.m111.230151