Zobrazeno 1 - 10
of 408
pro vyhledávání: '"Linda G Griffith"'
Autor:
Jianbo Zhang, Yu-Ja Huang, Martin Trapecar, Charles Wright, Kirsten Schneider, John Kemmitt, Victor Hernandez-Gordillo, Jun Young Yoon, Mathilde Poyet, Eric J. Alm, David T. Breault, David L. Trumper, Linda G. Griffith
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health. However, there is no existing system for a long-term co-culture of human innate immune cells with epithelium and oxygen-intolerant commensal microbes,
Externí odkaz:
https://doaj.org/article/f385e88a79b24dc9bc17f31a90057b1f
Autor:
Alessandra Dall’Agnese, Jesse M. Platt, Ming M. Zheng, Max Friesen, Giuseppe Dall’Agnese, Alyssa M. Blaise, Jessica B. Spinelli, Jonathan E. Henninger, Erin N. Tevonian, Nancy M. Hannett, Charalampos Lazaris, Hannah K. Drescher, Lea M. Bartsch, Henry R. Kilgore, Rudolf Jaenisch, Linda G. Griffith, Ibrahim I. Cisse, Jacob F. Jeppesen, Tong I. Lee, Richard A. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.
Externí odkaz:
https://doaj.org/article/b6a27a393d354ad08dc4d2e2cdc0f034
Autor:
Alex J. Wang, Allysa Allen, Marianna Sofman, Pierre Sphabmixay, Ece Yildiz, Linda G. Griffith
Publikováno v:
Advanced NanoBiomed Research, Vol 2, Iss 1, Pp n/a-n/a (2022)
In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. This study
Externí odkaz:
https://doaj.org/article/fd6252c1f1ac403aa15a5eee999e2759
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Metastatic breast cancer remains a largely incurable and fatal disease with liver involvement bearing the worst prognosis. The danger is compounded by a subset of disseminated tumor cells that may lie dormant for years to decades before re-emerging a
Externí odkaz:
https://doaj.org/article/f388283e67f24b669df2281c62c26233
Autor:
Christian Maass, Matthew Dallas, Matthew E. LaBarge, Michael Shockley, Jorge Valdez, Emily Geishecker, Cynthia L. Stokes, Linda G. Griffith, Murat Cirit
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Microphysiological systems (MPS), consisting of tissue constructs, biomaterials, and culture media, aim to recapitulate relevant organ functions in vitro. MPS components are housed in fluidic hardware with operational protocols, such as peri
Externí odkaz:
https://doaj.org/article/a3e52ad9c3af416aad7fb8fc0c9a0240
Autor:
Douglas A. Lauffenburger, Frank B. Gertler, Keith T. Flaherty, Ralph Weissleder, Hakho Lee, Linda G. Griffith, Jenny Tadros, Dennie T. Frederick, Hyungsoon Im, Aaron S. Meyer, Stephanie J. Wang, Ryan J. Sullivan, Madeleine J. Oudin, Miles A. Miller
Supplementary Figure S2. Correlation between plasma RTK changes with MAPKi, PFS, and initial tumor shrinkage (using RECIST) in melanoma patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abffd619ecd3d7949ca5c09957d7fa26
https://doi.org/10.1158/2159-8290.22531205.v1
https://doi.org/10.1158/2159-8290.22531205.v1
Autor:
Douglas A. Lauffenburger, Frank B. Gertler, Keith T. Flaherty, Ralph Weissleder, Hakho Lee, Linda G. Griffith, Jenny Tadros, Dennie T. Frederick, Hyungsoon Im, Aaron S. Meyer, Stephanie J. Wang, Ryan J. Sullivan, Madeleine J. Oudin, Miles A. Miller
Supplementary Methods, Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101cd835df1faa6b530bfe5aad3ff365
https://doi.org/10.1158/2159-8290.22531187.v1
https://doi.org/10.1158/2159-8290.22531187.v1
Autor:
Roger D. Kamm, Rashid Bashir, Natasha Arora, Roy D. Dar, Martha U. Gillette, Linda G. Griffith, Melissa L. Kemp, Kathy Kinlaw, Michael Levin, Adam C. Martin, Todd C. McDevitt, Robert M. Nerem, Mark J. Powers, Taher A. Saif, James Sharpe, Shuichi Takayama, Shoji Takeuchi, Ron Weiss, Kaiming Ye, Hannah G. Yevick, Muhammad H. Zaman
Publikováno v:
APL Bioengineering, Vol 2, Iss 4, Pp 040901-040901-21 (2018)
Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manuf
Externí odkaz:
https://doaj.org/article/fb4c6fc57d0444e39750e5d912c2d6de
Autor:
Timothy Kassis, Paola M. Perez, Chloe J.W. Yang, Luis R. Soenksen, David L. Trumper, Linda G. Griffith
Publikováno v:
HardwareX, Vol 4, Iss , Pp - (2018)
With the rise of research utilizing microphysiological systems (MPSs), the need for tools that enable the physiological mimicking of the relevant cellular environment is vital. The limited ability to reproduce crucial features of the microenvironment
Externí odkaz:
https://doaj.org/article/e63c7cd5786b4ab6a3018b892eaf3d48
Autor:
Douglas A. Lauffenburger, Jack R. Wands, Linda G. Griffith, Michael T. Hemann, Benjamin D. Cosgrove, Justin R. Pritchard
Supplementary Figures 1-2 from Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec30ee9840bf4b76cb2de9395efea84
https://doi.org/10.1158/1535-7163.22484621
https://doi.org/10.1158/1535-7163.22484621