Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Linda G, Griffith"'
Autor:
Jianbo Zhang, Yu-Ja Huang, Martin Trapecar, Charles Wright, Kirsten Schneider, John Kemmitt, Victor Hernandez-Gordillo, Jun Young Yoon, Mathilde Poyet, Eric J. Alm, David T. Breault, David L. Trumper, Linda G. Griffith
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Crosstalk of microbes with human gut epithelia and immune cells is crucial for gut health. However, there is no existing system for a long-term co-culture of human innate immune cells with epithelium and oxygen-intolerant commensal microbes,
Externí odkaz:
https://doaj.org/article/f385e88a79b24dc9bc17f31a90057b1f
Autor:
Alessandra Dall’Agnese, Jesse M. Platt, Ming M. Zheng, Max Friesen, Giuseppe Dall’Agnese, Alyssa M. Blaise, Jessica B. Spinelli, Jonathan E. Henninger, Erin N. Tevonian, Nancy M. Hannett, Charalampos Lazaris, Hannah K. Drescher, Lea M. Bartsch, Henry R. Kilgore, Rudolf Jaenisch, Linda G. Griffith, Ibrahim I. Cisse, Jacob F. Jeppesen, Tong I. Lee, Richard A. Young
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The authors find that the insulin receptor forms dynamic clusters during insulin signaling and that these clusters become dysfunctional in insulin resistance. This dysfunction is partially rescued by metformin, a drug used to treat type 2 diabetes.
Externí odkaz:
https://doaj.org/article/b6a27a393d354ad08dc4d2e2cdc0f034
Autor:
Alex J. Wang, Allysa Allen, Marianna Sofman, Pierre Sphabmixay, Ece Yildiz, Linda G. Griffith
Publikováno v:
Advanced NanoBiomed Research, Vol 2, Iss 1, Pp n/a-n/a (2022)
In vitro models of human liver functions are used across a diverse range of applications in preclinical drug development and disease modeling, with particular increasing interest in models that capture facets of liver inflammatory status. This study
Externí odkaz:
https://doaj.org/article/fd6252c1f1ac403aa15a5eee999e2759
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Metastatic breast cancer remains a largely incurable and fatal disease with liver involvement bearing the worst prognosis. The danger is compounded by a subset of disseminated tumor cells that may lie dormant for years to decades before re-emerging a
Externí odkaz:
https://doaj.org/article/f388283e67f24b669df2281c62c26233
Autor:
Christian Maass, Matthew Dallas, Matthew E. LaBarge, Michael Shockley, Jorge Valdez, Emily Geishecker, Cynthia L. Stokes, Linda G. Griffith, Murat Cirit
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Microphysiological systems (MPS), consisting of tissue constructs, biomaterials, and culture media, aim to recapitulate relevant organ functions in vitro. MPS components are housed in fluidic hardware with operational protocols, such as peri
Externí odkaz:
https://doaj.org/article/a3e52ad9c3af416aad7fb8fc0c9a0240
Autor:
Douglas A. Lauffenburger, Frank B. Gertler, Keith T. Flaherty, Ralph Weissleder, Hakho Lee, Linda G. Griffith, Jenny Tadros, Dennie T. Frederick, Hyungsoon Im, Aaron S. Meyer, Stephanie J. Wang, Ryan J. Sullivan, Madeleine J. Oudin, Miles A. Miller
Supplementary Figure S2. Correlation between plasma RTK changes with MAPKi, PFS, and initial tumor shrinkage (using RECIST) in melanoma patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abffd619ecd3d7949ca5c09957d7fa26
https://doi.org/10.1158/2159-8290.22531205.v1
https://doi.org/10.1158/2159-8290.22531205.v1
Autor:
Douglas A. Lauffenburger, Frank B. Gertler, Keith T. Flaherty, Ralph Weissleder, Hakho Lee, Linda G. Griffith, Jenny Tadros, Dennie T. Frederick, Hyungsoon Im, Aaron S. Meyer, Stephanie J. Wang, Ryan J. Sullivan, Madeleine J. Oudin, Miles A. Miller
Supplementary Methods, Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101cd835df1faa6b530bfe5aad3ff365
https://doi.org/10.1158/2159-8290.22531187.v1
https://doi.org/10.1158/2159-8290.22531187.v1
Autor:
Patrick Guye, Mohammad R. Ebrahimkhani, Nathan Kipniss, Jeremy J. Velazquez, Eldi Schoenfeld, Samira Kiani, Linda G. Griffith, Ron Weiss
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
There has been limited success in generating tissues from human induced pluripotent stem cells (hiPSCs). Here, the authors genetically engineer expression of the transcription factor Gata6 in a single isogenic hiPSC population resulting in complex ti
Externí odkaz:
https://doaj.org/article/9b8be1df7dff49edbe97c27e4110a2e7
Autor:
Douglas A. Lauffenburger, Jack R. Wands, Linda G. Griffith, Michael T. Hemann, Benjamin D. Cosgrove, Justin R. Pritchard
Supplementary Figures 1-2 from Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec30ee9840bf4b76cb2de9395efea84
https://doi.org/10.1158/1535-7163.22484621
https://doi.org/10.1158/1535-7163.22484621
Autor:
Douglas A. Lauffenburger, Jack R. Wands, Linda G. Griffith, Michael T. Hemann, Benjamin D. Cosgrove, Justin R. Pritchard
Multitarget compounds that act on a diverse set of regulatory pathways are emerging as a therapeutic approach for a variety of cancers. Toward a more specified use of this approach, we hypothesize that the desired efficacy can be recreated in terms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155bc32f08182681d0ac70a98c2a0e69
https://doi.org/10.1158/1535-7163.c.6531494.v1
https://doi.org/10.1158/1535-7163.c.6531494.v1