Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Linda Fredriksson"'
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Early breach of the blood–brain barrier (BBB) and consequently extravasation of blood-borne substances into the brain parenchyma is a common hallmark of ischemic stroke. Although BBB breakdown is associated with an increased risk of cerebr
Externí odkaz:
https://doaj.org/article/a0ade1819ef1458ab34a1d50f56dc6f7
Autor:
Simona Hankeova, Noemi Van Hul, Jakub Laznovsky, Elisabeth Verboven, Katrin Mangold, Naomi Hensens, Csaba Adori, Elvira Verhoef, Tomas Zikmund, Feven Dawit, Michaela Kavkova, Jakub Salplachta, Marika Sjöqvist, Bengt R Johansson, Mohamed G Hassan, Linda Fredriksson, Karsten Baumgärtel, Vitezslav Bryja, Urban Lendahl, Andrew Jheon, Florian Alten, Kristina Teär Fahnehjelm, Björn Fischler, Jozef Kaiser, Emma R Andersson
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-23 (2022)
Abstract Spontaneous bleeds are a leading cause of death in the pediatric JAG1‐related liver disease Alagille syndrome (ALGS). We asked whether there are sex differences in bleeding events in patients, whether Jag1Ndr/Ndr mice display bleeds or vas
Externí odkaz:
https://doaj.org/article/06eb0c1933c14c07a0211bd34884636e
Autor:
Manuel Zeitelhofer, Milena Z. Adzemovic, Christine Moessinger, Christina Stefanitsch, Carina Strell, Lars Muhl, Lou Brundin, Linda Fredriksson, Tomas Olsson, Ulf Eriksson, Ingrid Nilsson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-21 (2020)
Abstract Disruption of blood–brain barrier (BBB) integrity is a feature of various neurological disorders. Here we found that the BBB is differently affected during the preclinical, progression and remission phase of experimental autoimmune encepha
Externí odkaz:
https://doaj.org/article/18f04bdb2bef420e877bfd4a06c159be
Autor:
Johanna Andrae, Leonor Gouveia, Radiosa Gallini, Liqun He, Linda Fredriksson, Ingrid Nilsson, Bengt R. Johansson, Ulf Eriksson, Christer Betsholtz
Publikováno v:
Biology Open, Vol 5, Iss 4, Pp 461-474 (2016)
Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis of Pdgfc null mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy
Externí odkaz:
https://doaj.org/article/95e79d6dd6f84317a21580160c2d3d97
Autor:
Linda Fredriksson, Milena Z. Adzemovic, Lou Brundin, Tomas Olsson, Carina Strell, Christina Stefanitsch, Manuel Zeitelhofer, Christine Moessinger, Ingrid Nilsson, Lars Muhl, Ulf Eriksson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-21 (2020)
Scientific Reports
Scientific Reports
Disruption of blood–brain barrier (BBB) integrity is a feature of various neurological disorders. Here we found that the BBB is differently affected during the preclinical, progression and remission phase of experimental autoimmune encephalomyeliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46ad1561899775e35c9f03d2e443970
https://doaj.org/article/18f04bdb2bef420e877bfd4a06c159be
https://doaj.org/article/18f04bdb2bef420e877bfd4a06c159be
Autor:
Andreia Goncalves, Enming J Su, Arivalagan Muthusamy, Manuel Zeitelhofer, Daniel Torrente, Ingrid Nilsson, Jil Protzmann, Linda Fredriksson, Ulf Eriksson, David A Antonetti, Daniel A Lawrence
Publikováno v:
Blood.
The current standard of care for moderate to severe ischemic stroke is thrombolytic therapy with tissue plasminogen activator (tPA). Treatment with tPA can significantly improve neurological outcomes; however, thrombolytic therapy is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8305e1b70c47c8e70c8caa3256b8f746
https://doi.org/10.1182/blood.2021014958
https://doi.org/10.1182/blood.2021014958
Autor:
D. Torrente, J. Protzmann, Ej. Su, Sebastian A. Lewandowski, Milena Z. Adzemovic, Manuel Zeitelhofer, Ulf Eriksson, Linda Fredriksson, Christina Stefanitsch, Daniel A. Lawrence, Lars Muhl, Ida A. K. Nilsson
The tyrosine kinase inhibitor imatinib has been reported to improve outcome in patients following ischemic stroke but the exact mechanism remains elusive. Here, utilizing a photothrombotic murine model of middle cerebral artery occlusion (MCAO), we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d93849ca86882b3b274a07cd00cc71e3
https://doi.org/10.1101/2021.10.28.466225
https://doi.org/10.1101/2021.10.28.466225
Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke
Autor:
Daniel Torrente, Enming Joseph Su, Linda Fredriksson, Mark Warnock, David Bushart, Kris M. Mann, Cory D. Emal, Daniel A. Lawrence
Publikováno v:
Translational stroke research. 13(5)
Tissue plasminogen activator (tPA) is a multifunctional protease. In blood tPA is best understood for its role in fibrinolysis, whereas in the brain tPA is reported to regulate blood-brain barrier (BBB) function and to promote neurodegeneration. Thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf41fbdcf4a7caf43ff66841cbfe561
https://pubmed.ncbi.nlm.nih.gov/35122213
https://pubmed.ncbi.nlm.nih.gov/35122213
Autor:
T.B. Käll, J. Höijer, Ann Charlotte Laska, Håkan Almqvist, Naila Ahmed, Nils Wahlgren, M. Thorén, Bo Höjeberg, Anders Lilja, Staffan Holmin, Daniel A. Lawrence, Linda Fredriksson, Christina Sjöstrand, Ulf Eriksson
Publikováno v:
Journal of Internal Medicine. 281:273-283
Background Imatinib, a tyrosine kinase inhibitor, has been shown to restore blood–brain barrier integrity and reduce infarct size, haemorrhagic transformation and cerebral oedema in stroke models treated with tissue plasminogen activator. We evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2982e3a4cea08eca5f495c1ae38074
https://doi.org/10.1111/joim.12576
https://doi.org/10.1111/joim.12576
Publikováno v:
Seminars in Thrombosis and Hemostasis. 43:154-168
The plasminogen activation (PA) system is best known for its role in fibrinolysis. However, it has also been shown to regulate many non-fibrinolytic functions in the central nervous system (CNS). In particular, tissue-type plasminogen activator (tPA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783693fa12bc64993483d9060d71f16f
https://doi.org/10.1055/s-0036-1586229
https://doi.org/10.1055/s-0036-1586229