Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Linda Flebbe-Rehwaldt"'
Autor:
Heather A. Morgans, Todd Bradley, Linda Flebbe-Rehwaldt, Rangaraj Selvarangan, Amber Bagherian, Aliessa P. Barnes, Julie Bass, Ashley M. Cooper, Ryan Fischer, Steve Kleiboeker, Brian R. Lee, Cas LeMaster, Kelsey Markus, Stephen Morrison, Angela Myers, Doug Myers, Erin Payne, Jennifer E. Schuster, Sarah Standley, Andrea Wieser, Bradley Warady
Publikováno v:
Pediatric research.
A suboptimal response to the 2-dose COVID-19 vaccine series in the immunocompromised population prompted recommendations for a 3rd primary dose. We aimed to determine the humoral and cellular immune response to the 3rd COVID-19 vaccine in immunocompr
Publikováno v:
Transplantation and Cellular Therapy. 28:S376
Publikováno v:
Gene Therapy
Neonatal AAV8-mediated Factor IX (F.IX) gene delivery was applied as a model for exploring mechanisms of tolerance induction during immune ontogeny. Intraperitoneal delivery of AAV8/ Factor IX (hF.IX) during weeks 1-4 of life, over a 20-fold dose ran
Autor:
Yimin Shi, Linda Flebbe-Rehwaldt, Stanton L. Gerson, Jianqing Zhang, Rustom Falahati, Karin M.L. Gaensler
Publikováno v:
Molecular Therapy. 20(11):2180-2189
The feasibility of allogeneic transplantation, without myeloablation or post-transplant immunosuppression, was tested using in vivo chemoselection of allogeneic hematopoietic stem cells (HSCs) after transduction with a novel tricistronic lentiviral v
Autor:
Linda Flebbe-Rehwaldt, Stephanie Fausett, Steve Kleiboeker, Chrissy Cordes, Cory B. Lutgen, Kathie Steffens, Michelle Altrich, Jessica Rodgers
Publikováno v:
Open Forum Infectious Diseases
Background Infection and disease from human cytomegalovirus (CMV) is a major complicating factor for both solid organ and hematopoietic stem cell transplant recipients. Antiviral therapy is often used to control CMV infections, but presents problems
Publikováno v:
Proceedings of the National Academy of Sciences. 100:3374-3379
The human β-globin locus has been extensively studied as a model of tissue and developmental stage-specific gene expression. Structural mapping of naturally occurring mutations, including transfection and transgenic studies, and the recent finding o
Publikováno v:
Molecular Therapy. 2(4):374-380
Adenovirus-mediated gene delivery is limited by the induction of immune responses that produce toxicity and prevent reexpression. To determine whether adenoviral delivery in the preimmune fetus would produce tolerance, we assessed luciferase ( luc )
Autor:
Karin M.L. Gaensler, Linda Flebbe-Rehwaldt, Rita Sarkar, Haig H. Kazazian, Gerald S. Lipshutz
Publikováno v:
Proceedings of the National Academy of Sciences. 96:13324-13329
Development of in utero gene transfer approaches may provide therapies for genetic disorders with perinatal morbidity. In hemophilia A, prenatal and postnatal bleeding may be catastrophic, and modest increments in factor VIII (FVIII) activity are the
Publikováno v:
Surgery. 126:171-177
Background: The development of effective gene transfer in utero will provide alternative approaches to the treatment of genetic disorders. For many disorders, the fetal liver and peritoneum are important target tissues. Our goals were to compare the
Publikováno v:
Journal of Surgical Research. 84:150-156
Background. The development of strategies for gene transfer in utero will make possible the amelioration, and eventually the cure, of genetic diseases associated with pre- and postnatal morbidity and mortality. We have developed a murine model for in