Low-energy electrons transform the nimorazole molecule into a radiosensitiser

Autor: Rebecca Meißner, Jaroslav Kočišek, Linda Feketeová, Juraj Fedor, Michal Fárník, Paulo Limão-Vieira, Eugen Illenberger, Stephan Denifl

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)

Radiosensitisers are believed to interfere with cancer cells by dissociating upon interaction with electrons. Here the authors observe instead that the dominant path for nitroimidazolic radiosensitisers involves formation of a non-dissociated radical

Externí odkaz: https://doaj.org/article/cd9cad2156bb416a9e119dc7b675e27c

Electron Ionization of Imidazole and Its Derivative 2-Nitroimidazole

Autor: Rebecca, Meißner, Linda, Feketeová, Anita, Ribar, Katharina, Fink, Paulo, Limão-Vieira, Stephan, Denifl

Publikováno v: J.Am.Soc.Mass.Spectrom.
J.Am.Soc.Mass.Spectrom., 2019, 30 (12), pp.2678-2691. ⟨10.1007/s13361-019-02337-w⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of the American Society for Mass Spectrometry

FWF, Vienna, P30332 PD/BD/114452/2016 PTDC/FIS-AQM/31281/2017 PD/00193/2012 UID/FIS/00068/2019 P7440-035-011 ANR-10-LABX-0066 ANR-11-IDEX-0007 Imidazole (IMI) is a basic building block of many biologically important compounds. Thus, its electron ioni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d121a6f769b9dc49f3fa26bbf949487a
https://hdl.handle.net/10362/104547

High-energy collision-induced dissociation of histidine ions [His + H]+ and [His − H]− and histidine dimer [His2 + H]+

Autor: Julia Reitshammer, Violaine Vizcaino, Stephan Denifl, Kevin Klawitter, Linda Feketeová, Jusuf M. Khreis

Publikováno v: Rapid Commun.Mass.Spectr.
Rapid Commun.Mass.Spectr., 2017, 32 (2), pp.113-120. ⟨10.1002/rcm.8027⟩

International audience; Rationale Histidine (His) is an essential amino acid, whose side group consists of an aromatic imidazole moiety that can bind a proton or metal cation and act as a donor in intermolecular interactions in many biological proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec072b0fdbdc599603991dffa5b6f9cd
https://doi.org/10.1002/rcm.8027

Decomposition of protonated ronidazole studied by low-energy and high-energy collision-induced dissociation and density functional theory

Autor: Jusuf M. Khreis, Hassan Abdoul-Carime, João Ameixa, Fabien Chirot, T J Reddy, Bernadette Farizon, Richard A. J. O'Hair, Michel Farizon, F. Ferreira da Silva, Tilmann D. Märk, Stephan Denifl, S Pandeti, Linda Feketeová

Publikováno v: J.Chem.Phys.
J.Chem.Phys., 2019, 151 (16), pp.164306. ⟨10.1063/1.5118844⟩
Journal of Chemical Physics
Journal of Chemical Physics, American Institute of Physics, 2019, 151 (16), pp.164306. ⟨10.1063/1.5118844⟩

International audience; Nitroimidazoles are important compounds in medicine, biology, and the food industry. The growing need for their structural assignment, as well as the need for the development of the detection and screening methods, provides th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d60eed8c1f0710c891638ef10c99838
https://hal.archives-ouvertes.fr/hal-02362185

Reactions in the Radiosensitizer Misonidazole Induced by Low-Energy (0–10 eV) Electrons

Autor: Rebecca, Meißner, Linda, Feketeová, Eugen, Illenberger, Stephan, Denifl

Publikováno v: Int.J.Mol.Sc.
Int.J.Mol.Sc., 2019, 20 (14), pp.3496. ⟨10.3390/ijms20143496⟩
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3496 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 14

Misonidazole (MISO) was considered as radiosensitizer for the treatment of hypoxic tumors. A prerequisite for entering a hypoxic cell is reduction of the drug, which may occur in the early physical-chemical stage of radiation damage. Here we study el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7797512877b8343e56f5c3b02c1adc50
https://hal.archives-ouvertes.fr/hal-02277850