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RSPO3 is important for trabecular bone and fracture risk in mice and humans

Autor: Karin H Nilsson, Pedro P. C. Souza, Linda Engstrom Ruud, Charlotte Ejersted, Maha El Shahawy, Maria Nethander, Terho Lehtimäki, Thomas Levin Andersen, Jonathan H Tobias, Ulf H. Lerner, Antti Koskela, Sirui Zhou, Petra Henning, Juha Tuukkanen, Mattias Lorentzon, Karin Gustafsson, Sofia Movérare-Skrtic, J. Brent Richards, Claes Ohlsson, Jianyao Wu, Jan Tuckermann

Publikováno v: Nilsson, K H, Henning, P, Shahawy, M E, Nethander, M, Andersen, T L, Ejersted, C, Wu, J, Gustafsson, K L, Koskela, A, Tuukkanen, J, Souza, P P C, Tuckermann, J, Lorentzon, M, Ruud, L E, Lehtimäki, T, Tobias, J H, Zhou, S, Lerner, U H, Richards, J B, Movérare-Skrtic, S & Ohlsson, C 2021, ' RSPO3 is important for trabecular bone and fracture risk in mice and humans ', Nature Communications, vol. 12, 4923 . https://doi.org/10.1038/s41467-021-25124-2
Nilsson, K H, Henning, P, Shahawy, M E, Nethander, M, Andersen, T L, Ejersted, C, Wu, J, Gustafsson, K L, Koskela, A, Tuukkanen, J, Souza, P P C, Tuckermann, J, Lorentzon, M, Engstrom Ruud, L, Lehtimaki, T, Tobias, J H, Zhou, S, Lerner, U H, Richards, J B, Moverare-Skrtic, S & Ohlsson, C 2021, ' RSPO3 is important for trabecular bone and fracture risk in mice and humans ', Nature Communications, vol. 12, no. 1, 4923 . https://doi.org/10.1038/s41467-021-25124-2
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

With increasing age of the population, countries across the globe are facing a substantial increase in osteoporotic fractures. Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557d192dd887d01d6cc7db570daad747
https://findresearcher.sdu.dk:8443/ws/files/190718747/s41467_021_25124_2.pdf

Activation of GFRAL+ neurons induces hypothermia and glucoregulatory responses associated with nausea and torpor

Autor: Linda Engström Ruud, Ferran Font-Gironès, Joanna Zajdel, Lara Kern, Júlia Teixidor-Deulofeu, Louise Mannerås-Holm, Alba Carreras, Barbara Becattini, Andreas Björefeldt, Eric Hanse, Henning Fenselau, Giovanni Solinas, Jens C. Brüning, Thomas F. Wunderlich, Fredrik Bäckhed, Johan Ruud

Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 113960- (2024)

Summary: GFRAL-expressing neurons actuate aversion and nausea, are targets for obesity treatment, and may mediate metformin effects by long-term GDF15-GFRAL agonism. Whether GFRAL+ neurons acutely regulate glucose and energy homeostasis is, however,

Externí odkaz: https://doaj.org/article/aa3d323435254270b9519bdc32c22457

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IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling

Autor: Katharina Timper, Jesse Lee Denson, Sophie Marie Steculorum, Christian Heilinger, Linda Engström-Ruud, Claudia Maria Wunderlich, Stefan Rose-John, F. Thomas Wunderlich, Jens Claus Brüning

Publikováno v: Cell Reports, Vol 19, Iss 2, Pp 267-280 (2017)

Summary: Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find that central application of IL-6 in mice suppresses feeding and improves glucose tolerance. In contrast to leptin, whose action is attenuated in obesity, the ab

Externí odkaz: https://doaj.org/article/a8ed9d8fe2a341ffb5db1ab96e896bca