Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Linda Engström Ruud"'
Autor:
Linda Engström Ruud, Ferran Font-Gironès, Joanna Zajdel, Lara Kern, Júlia Teixidor-Deulofeu, Louise Mannerås-Holm, Alba Carreras, Barbara Becattini, Andreas Björefeldt, Eric Hanse, Henning Fenselau, Giovanni Solinas, Jens C. Brüning, Thomas F. Wunderlich, Fredrik Bäckhed, Johan Ruud
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113960- (2024)
Summary: GFRAL-expressing neurons actuate aversion and nausea, are targets for obesity treatment, and may mediate metformin effects by long-term GDF15-GFRAL agonism. Whether GFRAL+ neurons acutely regulate glucose and energy homeostasis is, however,
Externí odkaz:
https://doaj.org/article/aa3d323435254270b9519bdc32c22457
Autor:
Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, Thomas Levin Andersen, Charlotte Ejersted, Jianyao Wu, Karin L. Gustafsson, Antti Koskela, Juha Tuukkanen, Pedro P. C. Souza, Jan Tuckermann, Mattias Lorentzon, Linda Engström Ruud, Terho Lehtimäki, Jon H. Tobias, Sirui Zhou, Ulf H. Lerner, J. Brent Richards, Sofia Movérare-Skrtic, Claes Ohlsson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Genetic association signals for fractures have been reported at the RSPO3 locus, but the causal gene and the underlying mechanism are unknown. Here, the authors show that RSPO3 exerts an important role for vertebral trabecular bone mass and bone stre
Externí odkaz:
https://doaj.org/article/bb0475854da041a2990d5eeb48bf5cee
Autor:
Linda Engström Ruud, Mafalda M. A. Pereira, Alain J. de Solis, Henning Fenselau, Jens C. Brüning
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
AgRP-expressing neurons regulate feeding, glucose homeostasis and locomotor activity, but the neurotransmitters that mediate these effects are unclear. Here the authors show that neuropeptide Y in these neurons regulates rapid feeding responses and i
Externí odkaz:
https://doaj.org/article/56c5b96e122a451db613e7cb36275234
Autor:
Sophie Marie Steculorum, Katharina Timper, Linda Engström Ruud, Nadine Evers, Lars Paeger, Stephan Bremser, Peter Kloppenburg, Jens Claus Brüning
Publikováno v:
Cell Reports, Vol 18, Iss 7, Pp 1587-1597 (2017)
Uridine-diphosphate (UDP) and its receptor P2Y6 have recently been identified as regulators of AgRP neurons. UDP promotes feeding via activation of P2Y6 receptors on AgRP neurons, and hypothalamic UDP concentrations are increased in obesity. However,
Externí odkaz:
https://doaj.org/article/eb59b1abb5ef4d2382782dbf987e61af
Autor:
Johan Ruud, Jens Alber, Anna Tokarska, Linda Engström Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Änne Lautenschlager, Przemysław E. Cieślak, Łukasz Szumiec, Martin E. Hess, Hella S. Brönneke, Marcus Krüger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C. Brüning
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3182-3198.e9 (2019)
Summary: Variations in the human FTO gene have been linked to obesity and altered connectivity of the dopaminergic neurocircuitry. Here, we report that fat mass and obesity-associated protein (FTO) in dopamine D2 receptor-expressing medium spiny neur
Externí odkaz:
https://doaj.org/article/a536d8e99e444152a3de8a1661f87a00
Anorexia is a common symptom during infectious and inflammatory disease. Here we examined the role ofmelanocortin-4 receptors (MC4Rs) in inflammation-induced anorexia. Mice with transcriptional blockage of theMC4Rs displayed the same reduction of foo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f531ee0e17d583a61ef27b8fcc5956f8
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-195497
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-195497
Autor:
John-Olov Jansson, Fu-Ping Zhang, Jakob Bellman, Stefan Trapp, Matti Poutanen, Linda Engström-Ruud, Devesh Mishra, Fredrik Anesten, Karolina P. Skibicka, Adrià Dalmau Gasull, Vilborg Palsdottir
Publikováno v:
Neuroendocrinology. 109:310-321
Interleukin (IL)-6 in the hypothalamus and hindbrain is an important downstream mediator of suppression of body weight and food intake by glucagon-like peptide-1 (GLP-1) receptor stimulation. CNS GLP-1 is produced almost exclusively in prepro-glucago
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d813f5b1004ac3d65ec289bd8e2da5
https://doi.org/10.1159/000499693
https://doi.org/10.1159/000499693
Autor:
Stefan Rose-John, Jesse Lee Denson, Claudia M. Wunderlich, Linda Engström-Ruud, Jens C. Brüning, Sophie M. Steculorum, F. Thomas Wunderlich, Christian Heilinger, Katharina Timper
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 267-280 (2017)
Summary: Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find that central application of IL-6 in mice suppresses feeding and improves glucose tolerance. In contrast to leptin, whose action is attenuated in obesity, the ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92efa05f15b83cdad011baf401677417
https://doi.org/10.1016/j.celrep.2017.03.043
https://doi.org/10.1016/j.celrep.2017.03.043
Autor:
Alain de Solis, Linda Engström Ruud, Mafalda Maria Pereira, Henning Fenselau, Jens C. Brüning
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Activation of Agouti-Related Peptide (AgRP)-expressing neurons promotes feeding and insulin resistance. Here, we examine the contribution of neuropeptide Y (NPY)-dependent signaling to the diverse physiological consequences of activating AgRP neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911806e58ed5818c521217b7b0719253
https://pubmed.ncbi.nlm.nih.gov/31974377
https://pubmed.ncbi.nlm.nih.gov/31974377
Autor:
Katharina Timper, Heiko Backes, Philipp Hammerschmidt, Stephan Bremser, Thomas Benzing, Andreas Klein, Sophie M. Steculorum, Linda Engström Ruud, Peter Frommolt, Jens C. Brüning, Martin E. Hess, Johan Ruud, Jan Mauer, Donald A. Morgan, Paul Brinkkötter, Peter Kloppenburg, Ismene Karakasilioti, F. Thomas Wunderlich, Merly C. Vogt, Kamal Rahmouni, Eva Tsaousidou, Lars Paeger
Publikováno v:
Cell. 165(1):125-138
Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdcd3b8d0b70bb4c11c415a2f44fb2d0