hLMSC Secretome Affects Macrophage Activity Differentially Depending on Lung-Mimetic Environments

Autor: Bryan Falcones, Zackarias Söderlund, Arturo Ibáñez-Fonseca, Isaac Almendros, Jordi Otero, Ramon Farré, Sara Rolandsson Enes, Linda Elowsson Rendin, Gunilla Westergren-Thorsson

Publikováno v: Cells, Vol 11, Iss 12, p 1866 (2022)

Mesenchymal stromal cell (MSC)-based therapies for inflammatory diseases rely mainly on the paracrine ability to modulate the activity of macrophages. Despite recent advances, there is scarce information regarding changes of the secretome content att

Externí odkaz: https://doaj.org/article/0b3b2ddf9ca04128b2c946385a39c7a8

Harnessing the ECM Microenvironment to Ameliorate Mesenchymal Stromal Cell-Based Therapy in Chronic Lung Diseases

Autor: Linda Elowsson Rendin, Anna Löfdahl, Måns Kadefors, Zackarias Söderlund, Emil Tykesson, Sara Rolandsson Enes, Jenny Wigén, Gunilla Westergren-Thorsson

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

It is known that the cell environment such as biomechanical properties and extracellular matrix (ECM) composition dictate cell behaviour including migration, proliferation, and differentiation. Important constituents of the microenvironment, includin

Externí odkaz: https://doaj.org/article/a61df4d2c6d640cc9be3a4d8bc25a6b5

Correction: The proportion of alveolar type 1 cells decreases in murine hypoplastic congenital diaphragmatic hernia lungs.

Autor: Tram Mai Nguyen, Julio Jimenez, Linda Elowsson Rendin, Catharina Müller, Gunilla Westergren-Thorsson, Jan Deprest, Jaan Toelen

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0217322 (2019)

[This corrects the article DOI: 10.1371/journal.pone.0214793.].

Externí odkaz: https://doaj.org/article/040ef7b1c04e42cea0559a64d519b8bf

Distal Lung Microenvironment Triggers Release of Mediators Recognized as Potential Systemic Biomarkers for Idiopathic Pulmonary Fibrosis

Autor: Dimitrios Kalafatis, Anna Löfdahl, Per Näsman, Göran Dellgren, Åsa M. Wheelock, Linda Elowsson Rendin, Magnus Sköld, Gunilla Westergren-Thorsson

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13421, p 13421 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 24; Pages: 13421

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an unmet need of biomarkers that can aid in the diagnostic and prognostic assessment of the disease and response to treatment. In this two-part explorative proteomic stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd4daaa6228f2b145fd3343dc81756e
https://pubmed.ncbi.nlm.nih.gov/34948231

Late Breaking Abstract - Differential toxicities of particulate matter components linked to air pollution and adverse health effects

Autor: Daniel Kalbermatter, Michael Shaw, Nora Marek, Lena Scholtz, Sofie Orell, Monica Kåredal, Jenny Rissler, Nilofar Faruqui, Anna-Karin Larsson-Callerfelt, Camilla Dondi, Ute Resch-Genger, Linda Elowsson Rendin, Konstantina Vasilitou

Publikováno v: Occupational and environmental health.

Background: Particulate matter (PM) is a major component of ambient air pollution that has been linked to chronic lung disorders, especially COPD. Toxicity assessment of PM is currently typically based on mass concentration rather than the physicoche

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c399b67c5a0cc0f633df0d3eb09af73
https://doi.org/10.1183/13993003.congress-2021.pa3195