Výsledky vyhledávání - "Linda E. Keown"

Total Synthesis of Rhizoxin D, a Potent Antimitotic Agent from the Fungus Rhizopus chinensis

Autor: Paul R. Blakemore, Christine S. Nylund Kolz, Neal J. Green, James D. White, E Bryan Hauser, Linda E Keown, Mark A. Holoboski, Barton W. Phillips

Publikováno v: The Journal of Organic Chemistry. 67:7750-7760

Rhizoxin D (2) was synthesized from four subunits, A, B, C, and D representing C3-C9, C10-C13, C14-C19, and C20-C27, respectively. Subunit A was prepared by cyclization of iodo acetal 21, which set the configuration at C5 of 2 through a stereoselecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6645d54b150ffcbcba7aa3a764af9752
https://doi.org/10.1021/jo020537q

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Stereocontrolled Total Synthesis of (+)‐Altohyrtin A/Spongistatin 1

Autor: Ian Paterson, David Y.‐K. Chen, Mark J. Coster, Jose L. Aceña, Jordi Bach, Karl R. Gibson, Linda E. Keown, Renata M. Oballa, Thomas Trieselmann, Debra J. Wallace, Andrew P. Hodgson, Roger D. Norcross

Publikováno v: Angewandte Chemie. 113:4179-4184

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1f6e4eea8c1640679bf4d238cf7dae8
https://doi.org/10.1002/1521-3757(20011105)113:21<4179::aid-ange4179>3.0.co

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Studies in marine macrolide synthesis: Stereocontrolled synthesis of the F-ring subunit of spongistatin 1 (altohyrtin A)

Autor: Ian Paterson, Linda E. Keown

Publikováno v: Tetrahedron Letters. 38:5727-5730

The C36C46 subunit 3, containing the F ring of spongistatin 1 (1), was prepared in 12 steps from ketone (R)-7. Key steps include: (i) the boron-mediated anti aldol reaction, 7 → 9; (ii) the Sharpless AD, 6 → 13; and (iii) an intramolecular het

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2dba0c4a663691c1b37dc33cf72f4c49
https://doi.org/10.1016/s0040-4039(97)01257-4

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The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment

Autor: Linda E. Keown, Jose Luis Acena, Ian Paterson, Thomas Trieselmann, David Y.-K. Chen, Mark J. Coster, Jordi Bach

Publikováno v: Organicbiomolecular chemistry. 3(13)

The fully functionalised C29–C51 southern hemisphere of altohyrtin A/spongistatin 1 (1), incorporating the E- and F-ring tetrahydropyran rings and the unsaturated side chain, has been synthesised in a highly convergent and stereocontrolled manner.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daadb063981a937f260038ff6218eb5c
https://pubmed.ncbi.nlm.nih.gov/15976859

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Total Synthesis of Rhizoxin D (I), a Potent Antimitotic Agent from the Fungus Rhizopus chinensis

Autor: James D. White, Neal J. Green, Barton W. Phillips, Mark A. Holoboski, Paul R. Blakemore, E. Bryan Hauser, Linda E. Keown, Christine S. Nylund Kolz

Publikováno v: ChemInform. 34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49416b16a602b292291bace3c2606fa7
https://doi.org/10.1002/chin.200314232

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Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for generous support, and Dr. Anne Butlin (AZ) and Dr. Nick Bampos (Cambridge) for valuable assistance

Autor: Ian, Paterson, David Y.-K., Chen, Mark J., Coster, Jose L., Aceña, Jordi, Bach, Karl R., Gibson, Linda E., Keown, Renata M., Oballa, Thomas, Trieselmann, Debra J., Wallace, Andrew P., Hodgson, Roger D., Norcross

Publikováno v: Angewandte Chemie (International ed. in English). 40(21)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::573baa738777e7c2d94da4cefbfc147e
https://pubmed.ncbi.nlm.nih.gov/12404491

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ChemInform Abstract: Synthesis of Cytotoxic Marine Macrolides: An Aldol-Based Approach to Spongistatin 1 (Altohyrtin A)

Autor: Ian Paterson, Karl R. Gibson, Linda E. Keown, Roger D. Norcross, Renata M. Oballa, Debra J. Wallace

Publikováno v: ChemInform. 31

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94ad6cb3918cc86eb0b2472374d0d376
https://doi.org/10.1002/chin.200040285

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Synthesis of Cytotoxic Marine Macrolides: An Aldol-Based Approach to Spongistatin 1 (Altohyrtin A)

Autor: Renata M. Oballa, Roger David Norcross, Linda E. Keown, Debra J. Wallace, Ian Paterson, Karl Richard Gibson

Publikováno v: Current Trends in Organic Synthesis ISBN: 9781461371755

Marine organisms provide an important source of natural product diversity with an associated range of significant biological activities, which may provide new leads for drug discovery. For example, some of the most primitive multicellular invertebrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b8240e5dd3d857652a47f158756eb54
https://doi.org/10.1007/978-1-4615-4801-0_37

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