Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Linda E, Klumpers"'
Autor:
Michael, Tagen, Linda E, Klumpers
Publikováno v:
British journal of pharmacologyREFERENCES. 179(15)
The use of the intoxicating cannabinoid delta-8-tetrahydrocannabinol (Δ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::04a3e67ca89b31138b89a019e2aaee69
https://pubmed.ncbi.nlm.nih.gov/35523678
https://pubmed.ncbi.nlm.nih.gov/35523678
Autor:
David L. Thacker, Linda E. Klumpers
Publikováno v:
Journal of AOAC INTERNATIONAL. 102:412-420
Cannabis has been used as a medicinal plant for thousands of years. As a result of centuries of breeding and selection, there are now over 700 varieties of cannabis that contain hundreds of compounds, including cannabinoids and terpenes. Cannabinoids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::403c1b7b985d7fed0dfcbd801b09f722
https://doi.org/10.5740/jaoacint.18-0208
https://doi.org/10.5740/jaoacint.18-0208
Autor:
Zheng Guan, Olubukayo-Opeyemi Oyetayo, Jules A. A. C. Heuberger, Joop M. A. van Gerven, Jasper Stevens, Linda E. Klumpers
Publikováno v:
British Journal of Clinical Pharmacology. 81:713-723
Aim: The severe psychiatric side effects of cannabinoid receptor type 1 (CB1) antagonists hampered their wide development but this might be overcome by careful management of drug development with pharmacokinetic/pharmacodynamic (PK/PD) analyses. PK/P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b853af23e8035d096cc3692a69bcec2b
https://doi.org/10.1111/bcp.12852
https://doi.org/10.1111/bcp.12852
Autor:
Jules A. A. C. Heuberger, Jan Freijer, Paul D. Morrison, Olubukayo-Opeyemi Oyetayo, Zheng Guan, Tim L. Beumer, Adam F. Cohen, Linda E. Klumpers, Joop M. A. van Gerven
Publikováno v:
Clinical Pharmacokinetics, 54(2), 209-219
Δ(9)-Tetrahydrocannobinol (THC), the main psychoactive compound of Cannabis, is known to have a long terminal half-life. However, this characteristic is often ignored in pharmacokinetic (PK) studies of THC, which may affect the accuracy of predictio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf353647bd6db15435dea9952db7f269
https://doi.org/10.1007/s40262-014-0195-5
https://doi.org/10.1007/s40262-014-0195-5
Autor:
Marianne Fridberg, Paul Brian Little, Marieke L. de Kam, Linda E. Klumpers, Joop M. A. van Gerven, Niels Ole Jensen, Christian E. Elling, Hendrik D. Kleinloog
Publikováno v:
British Journal of Clinical Pharmacology. 76:846-857
Aim Cannabinoid receptor type 1 (CB1) antagonists show central side effects, whereas beneficial effects are most likely peripherally mediated. In this study, the peripherally selective CB1 antagonist TM38837 was studied in humans. Methods This was a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26203efcec7eec32743d57faabbe762
https://doi.org/10.1111/bcp.12141
https://doi.org/10.1111/bcp.12141
Autor:
Jean-Louis Pinquier, Frank A. S. Erwich, Sandrine Turpault, Franck Poitiers, Christine Roy, Linda E. Klumpers, Geraldine M. Ferron, Johan G. C. van Hasselt, Lineke Zuurman, Joop M. A. van Gerven
Publikováno v:
British Journal of Clinical Pharmacology. 76:65-77
Aim Cannabinoid receptor type 1 (CB1) antagonists have been developed for the treatment of obesity and associated risk factors. Surinabant is a high affinity CB1 antagonist in vitro. The aim of this study was to assess the magnitude of inhibition by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::209530f614adfebaa5fac4eeca02fd43
https://doi.org/10.1111/bcp.12071
https://doi.org/10.1111/bcp.12071
Autor:
Astrid Lipplaa, Jan Freijer, Tim L. Beumer, Lennard B. Karger, Joop M. A. van Gerven, Johan G. C. van Hasselt, Marieke L. de Kam, Linda E. Klumpers, H. Daniël Kleinloog
Publikováno v:
British Journal of Clinical Pharmacology. 74:42-53
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Cannabis based medicines are registered as a treatment for various indications, such as pain and spasms in multiple sclerosis (MS) patients, and anorexia and nausea in patients with HIV or receiving cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e93105508c0363dcc91541abf917665b
https://doi.org/10.1111/j.1365-2125.2012.04164.x
https://doi.org/10.1111/j.1365-2125.2012.04164.x
Autor:
Roelof P. Soeter, David M. Cole, Najmeh Khalili-Mahani, Linda E. Klumpers, Serge A.R.B. Rombouts, Erik T. te Beek, Joop M. A. van Gerven
Publikováno v:
NeuroImage, 63(3), 1701-1711
Resting state-functional magnetic resonance imaging (RS-FMRI) is a neuroimaging technique that allows repeated assessments of functional connectivity in resting state. While task-related FMRI is limited to indirectly measured drug effects in areas af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c52db623aeaa19e40ee7a3aba21c30c0
https://hdl.handle.net/1887/110295
https://hdl.handle.net/1887/110295
Autor:
Linda E, Klumpers, Tim L, Beumer, Johan G C, van Hasselt, Astrid, Lipplaa, Lennard B, Karger, H Daniël, Kleinloog, Jan I, Freijer, Marieke L, de Kam, Joop M A, van Gerven
Publikováno v:
British journal of clinical pharmacology. 74(1)
• Cannabis based medicines are registered as a treatment for various indications, such as pain and spasms in multiple sclerosis (MS) patients, and anorexia and nausea in patients with HIV or receiving cancer treatment. • the pharmacokinetics of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48c9278e70837ff1b3f3bd072682d6f0
https://pubmed.ncbi.nlm.nih.gov/22680341
https://pubmed.ncbi.nlm.nih.gov/22680341