Microvascular abnormalities secondary to radiation therapy in neovascular age-related macular degeneration: findings from the INTREPID clinical trial

Autor: Denis O'Shaughnessy, Florentina J. Freiberg, Linda Danielson, Usha Chakravarthy, Stephan Michels, Jason S. Slakter, Alyson Muldrew, Alan Czeszynski, Timothy L Jackson

Publikováno v: Freiberg, F J, Michels, S, Muldrew, A, Slakter, J, O'Shaughnessy, D, Czeszynski, A, Danielson, L, Jackson, T L & Chakravarthy, U 2018, ' Microvascular abnormalities secondary to radiation therapy in neovascular age-related macular degeneration : Findings from the INTREPID clinical trial ', The British journal of ophthalmology . https://doi.org/10.1136/bjophthalmol-2018-311865

PurposeTo report the incidence and features of retinal microvascular abnormalities (MVAs) occurring secondary to stereotactic radiotherapy (SRT) in a randomised double-masked sham-controlled clinical trial at 21 European sites.MethodsTwo hundred and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de80e53ba09891f41b60336ed08203e6
https://doi.org/10.1136/bjophthalmol-2018-311865

Stereotactic radiotherapy for neovascular age-related macular degeneration: year 2 results of the INTREPID study

Autor: Timothy L, Jackson, Usha, Chakravarthy, Jason S, Slakter, Alyson, Muldrew, E Mark, Shusterman, Denis, O'Shaughnessy, Mark, Arnoldussen, Michael E, Gertner, Linda, Danielson, Darius M, Moshfeghi, Yit, Yang

Publikováno v: Ophthalmology. 122(1)

To determine the safety and efficacy of low-voltage, external-beam, stereotactic radiotherapy (SRT) for patients with neovascular age-related macular degeneration (AMD).Randomized, double-masked, sham-controlled, multicenter, clinical trial.A total o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eeefbe77645d761d5a6bf5ba5023d876
https://pubmed.ncbi.nlm.nih.gov/25208859

Implementation Issues in Adaptive Design Trials

Autor: Jerome Carlier, Tomasz Burzykowski, Linda Danielson, Marc Buyse

Publikováno v: Practical Considerations for Adaptive Trial Design and Implementation ISBN: 9781493910991

In this chapter we discuss operational challenges that are specific to adaptive trials (as well as complex nonadaptive trials): essentially, the need to validate the design, to control the trial centrally, to collect and analyze key data rapidly, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d00fe1bc20d8cbdbbf0e6cf1bd5695e
https://doi.org/10.1007/978-1-4939-1100-4_12