Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Linda D. Thomas"'
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101742- (2023)
Objective: Low plasma levels of carotenoids are associated with mortality and chronic disease states. Genetic studies in animals revealed that the tissue accumulation of these dietary pigments is associated with the genes encoding β-carotene oxygena
Externí odkaz:
https://doaj.org/article/d9545ac3d6694ab68a521ba56f6a1e78
Faecal Microbiota Transfer/Transplantation (FMT) has seen impressive clinical outcomes in treating a range of disorders and illnesses. However there are few studies addressing short-term or long-term outcomes for healthy volunteers undergoing FMT wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c83f9c814273c53d26f32f5de9c5f2
Autor:
Ramkumar Srinivasagan, Nimesh Khadka, Marcin Golczak, Philip D. Kiser, Johannes von Lintig, Sepalika Bandara, Vipulkumar M. Parmar, Linda D. Thomas
Publikováno v:
J Biol Chem
The enzyme β-carotene oxygenase 2 (BCO2) converts carotenoids into more polar metabolites. Studies in mammals, fish, and birds revealed that BCO2 controls carotenoid homeostasis and is involved in the pathway for vitamin A production. However, it is
Autor:
Sepalika Bandara, Srinivasagan Ramkumar, Sanae Imanishi, Linda D. Thomas, Onkar B. Sawant, Yoshikazu Imanishi, Johannes von Lintig
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(15)
Some mammalian tissues uniquely concentrate carotenoids, but the underlying biochemical mechanism for this accumulation has not been fully elucidated. For instance, the central retina of the primate eyes displays high levels of the carotenoids, lutei
Autor:
Marcin Golczak, Linda D. Thomas, Johannes von Lintig, Philip D. Kiser, Sepalika Bandara, Srinivasagan Ramkumar, Nimesh Khadka
Publikováno v:
ACS Chem Biol
In mammals, carotenoids are converted by two carotenoid cleavage oxygenases into apocarotenoids, including vitamin A. Although knowledge about β-carotene oxygenase-1 (BCO1) and vitamin A metabolism has tremendously increased, the function of β-caro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411ad2885fbf6fceaaf5a4c7f91ea8b3
https://europepmc.org/articles/PMC8082539/
https://europepmc.org/articles/PMC8082539/
Publikováno v:
Methods in Molecular Biology ISBN: 9781493999514
Carotenoid cleavage dioxygenases (CCDs) are nonheme iron enzymes that catalyze double bond processing of carotenoids and their apocarotenoid metabolites. Mammalian genomes encode three members of this protein family, namely BCO1, BCO2, and RPE65. Mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86b3060be0a94ea80f9304cd93fb14f4
https://doi.org/10.1007/978-1-4939-9952-1_6
https://doi.org/10.1007/978-1-4939-9952-1_6
Publikováno v:
FEMS Immunology & Medical Microbiology. 37:155-160
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can cause fatal acute lung infections in critically ill individuals. Lung damage due to chronic infections in cystic fibrosis sufferers is the major cause of morbidity and mortality i
Publikováno v:
International Journal of Geriatric Psychiatry. 9:233-236
This study compared clinical diagnosis of dementia derived from medical records and a retrospective version of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) against the criterion of neuropathology. Subjects comprised 50 con
Autor:
Ursula Mönning, Qiao-Xin Li, Jon Currie, Robert D. Moir, Cees J. Van Tiggelen, Ashley I. Bush, Scott Whyte, Colin L. Masters, Timothy G. Williamson, Konrad Beyreuther, David H. Small, Baden Rumble, Linda D. Thomas
Publikováno v:
Annals of Neurology. 32:57-65
βA4 amyloid deposition in the brain, which is characteristic of Alzheimer's disease(AD), may result from either overexpression of the amyloid protein precursor (APP) or failure of APP to be correctly processed. A blood marker reflecting this abnorma
Publikováno v:
Vaccine. 27(25-26)
Pseudomonas aeruginosa is a major cause of nosocomal and community acquired chronic infections in subjects with compromised respiratory function. The microbe is environmentally ubiquitious and has a high level of innate antimicrobial resistance. This