Výsledky vyhledávání - "Linda D. Adams"

A regression analysis using simple descriptors for multiple dermal datasets: Going from individual membranes to the full skin

Autor: Marina V. Evans, Thomas E. Moxon, Guoping Lian, Benjamin N. Deacon, Tao Chen, Linda D. Adams, Annabel Meade, John F. Wambaugh

Publikováno v: Journal of Applied Toxicology. 43:940-950

In silico methods to estimate and/or quantify skin absorption of chemicals as a function of chemistry are needed to realistically predict pharmacological, occupational, and environmental exposures. The Potts-Guy equation is a well- established approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991dadd0ae2bd9a6b5f8dab083432137
https://doi.org/10.1002/jat.4435

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Association between mutation spectra and stable and unstable DNA adduct profiles in Salmonella for benzo[a]pyrene and dibenzo[a,l]pyrene

Autor: David M. DeMarini, Nancy M. Hanley, Sarah H. Warren, Linda D. Adams, Leon C. King

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 714:17-25

Benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP) are two polycyclic aromatic hydrocarbons (PAHs) that exhibit distinctly different mutagenicity and carcinogenicity profiles. Although some studies show that these PAHs produce unstable DNA adducts, con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6991b0623e43840e79741818c4769be
https://doi.org/10.1016/j.mrfmmm.2011.06.003

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Assessment of multiple types of DNA damage in human placentas from smoking and nonsmoking women in the Czech Republic

Autor: Miriam C. Poirier, Radim J. Sram, Ofelia A. Olivero, David M. DeMarini, Linda D. Adams, Paul Sirajuddin, M. Margaret Pratt, David K. Manchester, Kaarthik John, Leon C. King

Publikováno v: Environmental and Molecular Mutagenesis. 52:58-68

Three classes of DNA damage were assessed in human placentas collected (2000–2004) from 51 women living in the Teplice region of the Czech Republic, a mining area considered to have some of the worst environmental pollution in Europe in the 1980s.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9783c035a8dbbaad8817e0cea616e7a9
https://doi.org/10.1002/em.20581

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An Evaluation of the Mutagenicity, Metabolism, and DNA Adduct Formation of 5-Nitrobenzo[b]naphtho[2,1-d]thiophene

Autor: Stephen Nesnow, William T. Padgett, Dhimant Desai, Guy R. Lambert, Joycelyn Allison, Michael J. Kohan, Leon C. King, and Ann M. Richard, Garret B. Nelson, L. R. Brooks, Jeffrey A. Ross, Shantu Amin, Linda D. Adams

Publikováno v: Chemical Research in Toxicology. 14:661-671

Thioarenes, sulfur-containing polycyclic aromatic compounds, are environmental contaminants suspected of posing human health risks. In this study, 5-nitrobenzo[b]naphtho[2,1-d]thiophene (5-nitro-BNT), a nitrated-thioarene, was examined for its mutage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92318ebe236581ec83e5978c6b643e3b
https://doi.org/10.1021/tx0001373

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Biotransformation and DNA Adduct Formation ofTrans-8,9-Dihydroxy-8,9-Dihydrodibenzo[a, l]Pyrene by Induced Rat Liver and Human CYP1A1 Microsomes

Autor: Stephen Nesnow, Leon C. King, C. Davis, Guy R. Lambert, Michael H. George, William T. Padgett, Linda D. Adams

Publikováno v: Polycyclic Aromatic Compounds. 16:181-190

In order to explain the adduct patterns observed from the human CYP1A1-mediated binding of dibenzo[a, l]pyrene (DB[a, l]P) to DNA, we have investigated the further metabolism and DNA adduct activity of trans-DB[a, l]P-8,9-diol by induced rat liver an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b95733bad2ab792c70739d457782f0ad
https://doi.org/10.1080/10406639908020585

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8,9-Dihydroxy-8,9-dihydrodibenzo[ a , l ]pyrene is a potent morphological cell-transforming agent in C3H10T 1 / 2 Cl8 mouse embryo fibroblasts in the absence of detectable stable covalent DNA adducts

Autor: William T. Padgett, C. Davis, Leon C. King, Stephen Nesnow, Michele Yacopucci, Linda D. Adams

Publikováno v: Carcinogenesis. 21:1253-1257

The comparative genotoxic effects of racemic trans-8,9-dihydroxy-8, 9-dihydrodibenzo[a,l]pyrene (trans-DB[a,l]P-8,9-diol), the metabolic K-region dihydrodiol of dibenzo[a,l] pyrene (DB[a,l]P) (dibenzo[def, p]chrysene) and DB[a,l]P in transformable mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adc70ed3f1d2affd62256cbf0785baa
https://doi.org/10.1093/carcin/21.6.1253

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A quantitative comparison of dibenzo[a,l]pyrene-DNA adduct formation by recombinant human cytochrome P450 microsomes

Autor: Jeffrey A. Ross, Joycelyn Allison, Michael J. Kohan, Dhimant Desai, Leon C. King, Shantu Amin, Garret B. Nelson, Linda D. Adams

Publikováno v: Molecular Carcinogenesis. 26:74-82

Dibenzo[a,l]pyrene (DB[a,l]P), an extremely potent environmental carcinogen, is metabolically activated in mammalian cells and microsomes through the fjord-region dihydrodiol, trans-DB[a,l]P-11, 12-diol, to syn- and anti-DB[a,l]P-11,12-diol-13,14-epo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b5eaf91fadcf6062083e72e6b151e68
https://doi.org/10.1002/(sici)1098-2744(199910)26:2<74::aid-mc2>3.0.co

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Comparison of the morphological transforming activities of dibenzo[a,l]pyrene and benzo[a]pyrene in C3H10T1/2CL8 cells and characterization of the dibenzo[a,l]pyrene-DNA adducts

Autor: Garret B. Nelson, C. Davis, Jeffrey A. Ross, J Allison, Linda D. Adams, Stephen Nesnow, Leon C. King

Publikováno v: Carcinogenesis. 18:1973-1978

C3H10T1/2CL8 (C3H10T1/2) mouse embryo fibroblasts were used to study the in vitro carcinogenic activities of dibenzo[a,l]pyrene (DB[a,l]P) and benzo[a]pyrene (B[a]P). The morphological transforming activities of these rodent carcinogens were compared

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadc9477353283ffa65a0abee8239cb1
https://doi.org/10.1093/carcin/18.10.1973

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Lack of contribution of covalent benzo[a]pyrene-7,8-quinone-DNA adducts in benzo[a]pyrene-induced mouse lung tumorigenesis

Autor: Jeffrey A. Ross, Tanya Moore, Linda D. Adams, Stephen Nesnow, William T. Padgett, Michael H. George, Garret B. Nelson, Leon C. King

Publikováno v: Chemico-biological interactions. 186(2)

Benzo[a]pyrene (B[a]P) is a potent human and rodent lung carcinogen. This activity has been ascribed in part to the formation of anti-trans-7,8-dihydroxy-7,8-dihydroB[a]P-9,10-epoxide (BPDE)-DNA adducts. Other carcinogenic mechanisms have been propos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bbab6ebb488bc56d231034f3065985
https://pubmed.ncbi.nlm.nih.gov/20346927

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CD34 expression by hair follicle stem cells is required for skin tumor development in mice

Autor: Joanne G.W. Nijhof, Rebecca J. Morris, Leon C. King, John C. Peckham, Raymond W. Tennant, Mayumi Ito, Amy Elmore, Margaret M. Humble, Carl D. Bortner, Norris D. Flagler, Linda D. Adams, Grace E. Kissling, Dhimant Desai, George Cotsarelis, Matthew Ehinger, Shantu Amin, Carol S. Trempus

Publikováno v: Cancer research. 67(9)

The cell surface marker CD34 marks mouse hair follicle bulge cells, which have attributes of stem cells, including quiescence and multipotency. Using a CD34 knockout (KO) mouse, we tested the hypothesis that CD34 may participate in tumor development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46574376b8116780545b69d92bf812da
https://pubmed.ncbi.nlm.nih.gov/17483328

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