Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Linda Clipson"'
Autor:
Rebecca A. DeStefanis, Jeremy D. Kratz, Autumn M. Olson, Aishwarya Sunil, Alyssa K. DeZeeuw, Amani A. Gillette, Gioia C. Sha, Katherine A. Johnson, Cheri A. Pasch, Linda Clipson, Melissa C. Skala, Dustin A. Deming
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Representative models are needed to screen new therapies for patients with cancer. Cancer organoids are a leap forward as a culture model that faithfully represents the disease. Mouse-derived cancer organoids (MDCOs) are becoming increasingl
Externí odkaz:
https://doaj.org/article/0850400bc08146908046414b05f6fcca
Autor:
Alyssa A. Leystra, Brock J. Gilsdorf, Amanda M. Wisinger, Elise R. Warda, Shanna Wiegand, Christopher D. Zahm, Kristina A. Matkowskyj, Dustin A. Deming, Naghma Khan, Quincy Rosemarie, Chelsie K. Sievers, Alexander R. Schwartz, Dawn M. Albrecht, Linda Clipson, Hasan Mukhtar, Michael A. Newton, Richard B. Halberg
Publikováno v:
Cancer Reports, Vol 5, Iss 2, Pp n/a-n/a (2022)
Abstract Background Data are steadily accruing that demonstrate that intestinal tumors are frequently derived from multiple founding cells, resulting in tumors comprised of distinct ancestral clones that might cooperate or alternatively compete, ther
Externí odkaz:
https://doaj.org/article/8da5b0c5b0914ae6be7061afed01adcb
Autor:
Jennifer K Pleiman, Amy A Irving, Zhishi Wang, Erik Toraason, Linda Clipson, William F Dove, Dustin A Deming, Michael A Newton
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007611 (2018)
Conservation over three mammalian genera-the mouse, rat, and human-has been found for a subset of the transcripts whose level differs between the adenoma and normal epithelium of the colon. Pde4b is one of the triply conserved transcripts whose level
Externí odkaz:
https://doaj.org/article/8f6eb91913e744ebb694031853f1d680
Autor:
Amy A. Irving, Kazuto Yoshimi, Marcia L. Hart, Taybor Parker, Linda Clipson, Madeline R. Ford, Takashi Kuramoto, William F. Dove, James M. Amos-Landgraf
Publikováno v:
Disease Models & Mechanisms, Vol 7, Iss 11, Pp 1215-1225 (2014)
Prior to the advent of genetic engineering in the mouse, the rat was the model of choice for investigating the etiology of cancer. Now, recent advances in the manipulation of the rat genome, combined with a growing recognition of the physiological di
Externí odkaz:
https://doaj.org/article/e627bb63238d47cfbb1f092913536550
Autor:
Christopher D Zahm, Joseph M Szulczewski, Alyssa A Leystra, Terrah J Paul Olson, Linda Clipson, Dawn M Albrecht, Malisa Middlebrooks, Andrew T Thliveris, Kristina A Matkowskyj, Mary Kay Washington, Michael A Newton, Kevin W Eliceiri, Richard B Halberg
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150170 (2016)
A widely accepted paradigm in the field of cancer biology is that solid tumors are uni-ancestral being derived from a single founder and its descendants. However, data have been steadily accruing that indicate early tumors in mice and humans can have
Externí odkaz:
https://doaj.org/article/2e3dbb4f216143749f8ae0706d841ae3
Autor:
Alexander E Yueh, Susan N Payne, Alyssa A Leystra, Dana R Van De Hey, Tyler M Foley, Cheri A Pasch, Linda Clipson, Kristina A Matkowskyj, Dustin A Deming
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148730 (2016)
The phosphoinositide 3-kinase (PI3K) signaling pathway is critical for multiple important cellular functions, and is one of the most commonly altered pathways in human cancers. We previously developed a mouse model in which colon cancers were initiat
Externí odkaz:
https://doaj.org/article/43d47cd50a744f7b938ac68fd1de464b
Autor:
Nguyen H. Tran, Ludimila L. Cavalcante, Sam J. Lubner, Daniel L. Mulkerin, Noelle K. LoConte, Linda Clipson, Kristina A. Matkowskyj, Dustin A. Deming
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 7 (2015)
When considering treatment options for patients with metastatic colorectal cancer (mCRC), molecular profiling has become a pivotal component in guiding clinical decisions. FOLFOX and FOLFIRI (fluorouracuil, leucovorin plus oxaliplatin or ininotecan,
Externí odkaz:
https://doaj.org/article/c25529980d874e598914258b273dd480
Autor:
Jeffery W Bacher, Chelsie K Sievers, Dawn M Albrecht, Ian C Grimes, Jennifer M Weiss, Kristina A Matkowskyj, Rashmi M Agni, Irina Vyazunova, Linda Clipson, Douglas R Storts, Andrew T Thliveris, Richard B Halberg
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0132727 (2015)
Microsatellite instability (MSI) occurs in over 90% of Lynch syndrome cancers and is considered a hallmark of the disease. MSI is an early event in colon tumor development, but screening polyps for MSI remains controversial because of reduced sensiti
Externí odkaz:
https://doaj.org/article/649f3b4de0e94d8aaca74b8230ff0aad
Autor:
Dustin A Deming, Molly E Maher, Alyssa A Leystra, Joseph P Grudzinski, Linda Clipson, Dawn M Albrecht, Mary Kay Washington, Kristina A Matkowskyj, Lance T Hall, Sam J Lubner, Jamey P Weichert, Richard B Halberg
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109668 (2014)
The treatment of localized colorectal cancer (CRC) depends on resection of the primary tumor with adequate margins and sufficient lymph node sampling. A novel imaging agent that accumulates in CRCs and the associated lymph nodes is needed. Cellectar
Externí odkaz:
https://doaj.org/article/d90497f5ff9945f6b8b2860f54bd5187
Autor:
Dustin A Deming, Alyssa A Leystra, Mohammed Farhoud, Laura Nettekoven, Linda Clipson, Dawn Albrecht, Mary Kay Washington, Ruth Sullivan, Jamey P Weichert, Richard B Halberg
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60709 (2013)
The phosphatidylinositide-3-kinase (PI3K) signaling pathway is critical for multiple cellular functions including metabolism, proliferation, angiogenesis, and apoptosis, and is the most commonly altered pathway in human cancers. Recently, we develope
Externí odkaz:
https://doaj.org/article/d31eff1ed832492ba8863e2f9091656e