Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Linda Clipson"'
Autor:
Rebecca A. DeStefanis, Jeremy D. Kratz, Autumn M. Olson, Aishwarya Sunil, Alyssa K. DeZeeuw, Amani A. Gillette, Gioia C. Sha, Katherine A. Johnson, Cheri A. Pasch, Linda Clipson, Melissa C. Skala, Dustin A. Deming
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Representative models are needed to screen new therapies for patients with cancer. Cancer organoids are a leap forward as a culture model that faithfully represents the disease. Mouse-derived cancer organoids (MDCOs) are becoming increasingl
Externí odkaz:
https://doaj.org/article/0850400bc08146908046414b05f6fcca
Autor:
Alyssa A. Leystra, Brock J. Gilsdorf, Amanda M. Wisinger, Elise R. Warda, Shanna Wiegand, Christopher D. Zahm, Kristina A. Matkowskyj, Dustin A. Deming, Naghma Khan, Quincy Rosemarie, Chelsie K. Sievers, Alexander R. Schwartz, Dawn M. Albrecht, Linda Clipson, Hasan Mukhtar, Michael A. Newton, Richard B. Halberg
Publikováno v:
Cancer Reports, Vol 5, Iss 2, Pp n/a-n/a (2022)
Abstract Background Data are steadily accruing that demonstrate that intestinal tumors are frequently derived from multiple founding cells, resulting in tumors comprised of distinct ancestral clones that might cooperate or alternatively compete, ther
Externí odkaz:
https://doaj.org/article/8da5b0c5b0914ae6be7061afed01adcb
Autor:
Dustin A. Deming, Richard B. Halberg, Kristina A. Matkowskyj, Cheri A. Pasch, Linda Clipson, Dawn M. Albrecht, Alexander R. Schwartz, Alexander E. Yueh, Susan N. Payne, Molly E. Maher, Terrah J. Paul Olson, Alyssa A. Leystra, Jamie N. Hadac
Colonoscopic images over time, whole mount image and H&E-stained section of a tumor from a Apcfl/fl Pik3cap110* mouse inoculated with Adeno-Cre that spontaneously decreased in size.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c12dd3f9a1af0205ef1117b30e188d
https://doi.org/10.1158/1940-6207.22526871
https://doi.org/10.1158/1940-6207.22526871
Supplementary Figure S1 from MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers
Autor:
Dustin A. Deming, Melissa C. Skala, Michael A. Newton, Kristina A. Matkowskyj, Paraic A. Kenny, Benjamin M. Parsons, Kayla K. Lemmon, Mark E. Burkard, Linda Clipson, Rebecca A. DeStefanis, Gioia Chengcheng Sha, Demetra P. Korkos, Mitchell G. Depke, Dana R. Van De Hey, Alexander E. Yueh, Tyler M. Foley, Cheri A. Pasch, Jeremy D. Kratz, Peter F. Favreau, Susan N. Payne, Stephanie L. Fricke
Supplementary Figure S1 presents the viability of SW48 and SW48PK cells after treatment with BEZ235 and TAK-228 at the 100-400nM concentrations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3797d51c82d44138bbd5766b7be6a207
https://doi.org/10.1158/1535-7163.22507717.v1
https://doi.org/10.1158/1535-7163.22507717.v1
Autor:
Richard B. Halberg, William R. Schelman, Michael A. Newton, Ruth Sullivan, Linda Clipson, Lauren K. Plesh, Laura A. Nettekoven, Alice Nomura, Dawn M. Albrecht, Christopher D. Zahm, Dustin A. Deming, Alyssa A. Leystra, Chelsie K. Sievers, Jamie N. Hadac, Terrah J. Paul Olson
PDF file - 30K, Relative gene expression is shown for three adenomas and three intramucosal carcinomas taken from the colons of DSS-treated F1 Min mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ba7b91eb0984b007c5cbdb88b39142
https://doi.org/10.1158/1940-6207.22525532
https://doi.org/10.1158/1940-6207.22525532
Autor:
Dustin A. Deming, Richard B. Halberg, Kristina A. Matkowskyj, Cheri A. Pasch, Linda Clipson, Dawn M. Albrecht, Alexander R. Schwartz, Alexander E. Yueh, Susan N. Payne, Molly E. Maher, Terrah J. Paul Olson, Alyssa A. Leystra, Jamie N. Hadac
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0abe99044f3aaee1458db8643cde6a30
https://doi.org/10.1158/1940-6207.22526880
https://doi.org/10.1158/1940-6207.22526880
Autor:
Richard B. Halberg, William R. Schelman, Michael A. Newton, Ruth Sullivan, Linda Clipson, Lauren K. Plesh, Laura A. Nettekoven, Alice Nomura, Dawn M. Albrecht, Christopher D. Zahm, Dustin A. Deming, Alyssa A. Leystra, Chelsie K. Sievers, Jamie N. Hadac, Terrah J. Paul Olson
PDF file - 21K, Characteristics of F1 ApcMin/+ mice treated with 4% dextran sodium sulfate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aec4941d8ab0c4d89817711ec305684
https://doi.org/10.1158/1940-6207.22525529.v1
https://doi.org/10.1158/1940-6207.22525529.v1
Autor:
Dustin A. Deming, Michael A. Newton, Kristina A. Matkowskyj, Molly E Maher, Linda Clipson, Demetra P Korkos, Dana R Van De Hey, Alex E. Yueh, Cheri A. Pasch, Susan N. Payne, Tyler M Foley
S1. AP spheroids were plated and allowed to mature for 48 hours. S2. To address the issue of potentially slower growth of the spheres with the largest initial sizes, a change-point analysis was performed. S3. AP mice were treated with control (A) or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b40b59770a6d2023987e8d876e86d4
https://doi.org/10.1158/1541-7786.22515181
https://doi.org/10.1158/1541-7786.22515181
Autor:
Richard B. Halberg, William R. Schelman, Michael A. Newton, Ruth Sullivan, Linda Clipson, Lauren K. Plesh, Laura A. Nettekoven, Alice Nomura, Dawn M. Albrecht, Christopher D. Zahm, Dustin A. Deming, Alyssa A. Leystra, Chelsie K. Sievers, Jamie N. Hadac, Terrah J. Paul Olson
PDF file - 54K, Panel A illustrates the colonoscopic surveillance protocol. Panel B shows the serial biopsy protocol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::882cba53ae8de51cfd18e538be881d45
https://doi.org/10.1158/1940-6207.22525535
https://doi.org/10.1158/1940-6207.22525535
Autor:
Dustin A. Deming, Melissa C. Skala, Michael A. Newton, Kristina A. Matkowskyj, Paraic A. Kenny, Benjamin M. Parsons, Kayla K. Lemmon, Mark E. Burkard, Linda Clipson, Rebecca A. DeStefanis, Gioia Chengcheng Sha, Demetra P. Korkos, Mitchell G. Depke, Dana R. Van De Hey, Alexander E. Yueh, Tyler M. Foley, Cheri A. Pasch, Jeremy D. Kratz, Peter F. Favreau, Susan N. Payne, Stephanie L. Fricke
PIK3CA mutations are common in clinical molecular profiling, yet an effective means to target these cancers has yet to be developed. MTORC1 inhibitors are often used off-label for patients with PIK3CA mutant cancers with only limited data to support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61eef4938e53e1487200610ced459f4f
https://doi.org/10.1158/1535-7163.c.6538765.v1
https://doi.org/10.1158/1535-7163.c.6538765.v1