mTOR intersects antibody-inducing signals from TACI in marginal zone B cells

Autor: Jordi Sintes, Maurizio Gentile, Shuling Zhang, Yolanda Garcia-Carmona, Giuliana Magri, Linda Cassis, Daniel Segura-Garzón, Alessandra Ciociola, Emilie K. Grasset, Sabrina Bascones, Laura Comerma, Marc Pybus, David Lligé, Irene Puga, Cindy Gutzeit, Bing He, Wendy DuBois, Marta Crespo, Julio Pascual, Anna Mensa, Juan Ignacio Aróstegui, Manel Juan, Jordi Yagüe, Sergi Serrano, Josep Lloreta, Eric Meffre, Michael Hahne, Charlotte Cunningham-Rundles, Beverly A. Mock, Andrea Cerutti

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching

Externí odkaz: https://doaj.org/article/55fa5c77ea474673980a024897c7214c

Impact of Small Molecules Immunosuppressants on P-Glycoprotein Activity and T-cell Function

Autor: Inés Llaudó, Linda Cassis, Joan Torras, Oriol Bestard, Marcel·la Franquesa, Josep M. Cruzado, Gema Cerezo, Esther Castaño, Jordi Petriz, Immaculada Herrero-Fresneda, Josep M. Grinyó, Núria Lloberas

Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences, Vol 15, Iss 3 (2012)

Purpose. P-glycoprotein (Pgp) is a member of the ABC-transporter family that transports substances across cellular membranes acting as an efflux pump extruding drugs out of the cells. Pgp plays a key role on the pharmacokinetics of several drugs. Her

Externí odkaz: https://doaj.org/article/22f61bd308cd462c9d975adc63bb9102

The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells

Autor: Fernando Rodrigues, Jordi Sintes, A. Cooper Walland, Irene Puga, Jorge Carrillo, Helder Novais Bastos, Giovanni Salvatori, Andrea Cerutti, Adolfo García-Sastre, Meimei Shan, J. Magarian Blander, Alberto Mantovani, António Morais, Ramón García-Escudero, Nadia Polentarutti, João F. Lacerda, Linda Cassis, Sandra Casas-Recasens, Peter S. Heeger, Rebeca Dieguez-Gonzalez, Agostinho Carvalho, Cristina Cunha, John R. Yeiser, Cecilia Garlanda, Alejo Chorny

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The Journal of Experimental Medicine

© 2016 Chorny et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048229d8c79fc84511d4e63fe76dc27e
https://doi.org/10.1084/jem.20150282

The ethical framework for performing research with rare inherited neurometabolic disease patients

Autor: Francesca D’Avanzo, Ksenija Fumić, Lamis Ragab, Ljerka Cvitanovic-Sojat, Elisenda Cortès-Saladelafont, Hugo Devlieger, Christina Lampe, Maurizio Scarpa, Cinzia Maria Bellettato, Ángels Garcia Cazorla, Linda Cassis, Fedele Bonifazi, Viviana Giannuzzi, Viveca Odlind, Lucia Margari, Franco Bartoloni, Adriana Ceci, Ivo Barić, Christine í Dali

Publikováno v: European Journal of Pediatrics

The need for performing clinical trials to develop well-studied and appropriate medicines for inherited neurometabolic disease patients faces ethical concerns mainly raising from four aspects: the diseases are rare; include young and very young patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f47c295270e4eb4786ab77134d2022
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320839

Dendritic cells phenotype fitting under hypoxia or lipopolysaccharide; adenosine 5′-triphosphate-binding cassette transporters far beyond an efflux pump

Autor: Marcella Franquesa, Nuria Lloberas, Josep M. Grinyó, Linda Cassis, J. M. Cruzado, Gema Cerezo, Joan Torras, Immaculada Herrero-Fresneda, Ana Merino, Inés Rama, Inés Llaudó, Oriol Bestard, D. Benitez-Ribas

Publikováno v: Clinical and Experimental Immunology. 172:444-454

Summary This study examines adenosine 5′-triphosphate-binding cassette (ABC) transporters as a potential therapeutic target in dendritic cell (DC) modulation under hypoxia and lipopolysaccharide (LPS). Functional capacity of dendritic cells (DCs) (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f2893b493544ef1796fe85c8956ef5
https://doi.org/10.1111/cei.12067