Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Linda C. Quattrochi"'
Autor:
Ishtiaq Qadri, Ling-Jia Hu, Mieko Iwahashi, Subhi Al-Zuabi, Linda C. Quattrochi, Francis R. Simon
Publikováno v:
Toxicology and Applied Pharmacology. 234:281-292
Multidrug resistance-associated protein 2 (MRP2) (ABCC2) is an ATP-binding cassette membrane protein located primarily on apical surface of hepatocytes that mediates transport of conjugated xenobiotics and endogenous compounds into bile. MRP2 is high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b6914fa163cfb5f2acfbe39613234b
https://doi.org/10.1016/j.taap.2008.10.005
https://doi.org/10.1016/j.taap.2008.10.005
Autor:
Tzu L. Phang, Jeffrey P. Guzelian, Philip S. Guzelian, Linda C. Quattrochi, Joyce L. Barwick, Lawrence Hunter
Publikováno v:
Toxicological Sciences. 94:379-387
Mammalian liver contains a pregnane X receptor (PXR, NR1I2), which binds drugs and other xenobiotics, and stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cfed32584eb1a450ef493ba33acfb44
https://doi.org/10.1093/toxsci/kfl116
https://doi.org/10.1093/toxsci/kfl116
Autor:
Linda C. Quattrochi, Virginia H. Black
Publikováno v:
Drug Metabolism and Disposition. 32:595-602
Aromatic hydrocarbon (AH) effects are mediated by binding of the AH receptor and its heterodimeric partner aromatic hydrocarbon nuclear translocator to specific response elements on DNA (AHREs). CYP1A2 expression is induced by AHs, yet AHREs have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5aa5a6e2b805f27c02e260abb84f7dc
https://doi.org/10.1124/dmd.32.6.595
https://doi.org/10.1124/dmd.32.6.595
Publikováno v:
Biochemical Pharmacology. 65:1087-1096
Cytochrome P450 (CYP)1A2 is abundantly expressed in the liver of all vertebrate species. In most, its expression is restricted to the liver. Sequence analysis of the human CYP1A2 5′-flanking region from +3 to −3201 identified six E-box motifs wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e42fe2be076b304333219d33a15e4b
https://doi.org/10.1016/s0006-2952(03)00037-6
https://doi.org/10.1016/s0006-2952(03)00037-6
Autor:
Linda C. Quattrochi, Marilee J. Wick, Ishtiaq Qadri, Te-Yen Shiao, Francis R. Simon, Mieko Iwahashi, Susan Bowman, John Fortune
Publikováno v:
Genomics. 69:203-213
Bile salts are rapidly removed from the circulation by the liver-specific sodium/taurocholate cotransporter ( SLC10A1 ). To understand factors controlling its liver-specific expression, we isolated human SLC10A1 from a YAC chromosomal clone. SLC10A1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b74ec9c50ff4bd647bb6b7cc6a489b7
https://doi.org/10.1006/geno.2000.6329
https://doi.org/10.1006/geno.2000.6329
Publikováno v:
Archives of Biochemistry and Biophysics. 342:134-142
Our laboratory has proposed that phenobarbital (PB), a typical lipophilic agent that induces some members of the supergene family of liver microsomal cytochromes P450 (e.g., CYP2B1/2 and CYP3A23), acts through a complex process inhibitable by the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ca3bac35913e1100105d3fcefb9944
https://doi.org/10.1006/abbi.1997.0112
https://doi.org/10.1006/abbi.1997.0112
Publikováno v:
Environmental Toxicology and Chemistry. 14:1159-1169
In this study the authors describe the use of a transgenic cell line for the identification of potentially toxic compounds in test solutions and environmental samples. The reporter gene system (RGS), derived from a human liver cancer cell line, has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a51f00f6d43335690bec164837fe7fa2
https://doi.org/10.1002/etc.5620140706
https://doi.org/10.1002/etc.5620140706
Publikováno v:
Journal of Biological Chemistry. 269:6949-6954
The gene for cytochrome P4501A2 is constitutively expressed in the liver of vertebrates and shows induced expression when an organism is exposed to polycyclic aromatic hydrocarbons and halogenated hydrocarbons. To identify DNA elements regulating tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87fff259ead8ca64320cb393a18bf31
https://doi.org/10.1016/s0021-9258(17)37466-5
https://doi.org/10.1016/s0021-9258(17)37466-5
Publikováno v:
Toxicology and Applied Pharmacology. 118:255-262
The cytochrome P4501 gene family consists of two members, CYP1A1 and CYP1A2, that are induced by halogenated hydrocarbons and polycyclic aromatic hydrocarbons. The human CYP1 promoters and 5'-flanking sequences were cloned into luciferase expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00c4a9caa19b2adafeef094a4ec99cf6
https://doi.org/10.1006/taap.1993.1031
https://doi.org/10.1006/taap.1993.1031
Autor:
Pauline de la M. Hall, Ross A. McKinnon, Michael E. McManus, Robert H. Tukey, Linda C. Quattrochi
Publikováno v:
Hepatology. 14:848-856
To better characterize the precise cellular distribution of CYP1A gene products in man, we have undertaken Northern-blot and in situ hybridization analyses of CYP1A expression in human liver. Using riboprobes transcribed from both CYP1A1 and CYP1A2 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b89ab9f5e9c4c05408b4847e0319dea
https://doi.org/10.1002/hep.1840140517
https://doi.org/10.1002/hep.1840140517